The BsmI vitamin D-receptor polymorphism and secondary hyperparathyroidism

Response of parathyroid glands to calcitriol in culture: Is this response mediated by the genetic polymorphisms in vitamin D receptor?

“…In previous studies done in vivo [10, 11], these variables could mask the likely effect of the VDR polymorphisms on parathyroid DISCUSSION gland physiology. Recently, we have developed a new model of para-No differences were found in the distribution of the thyroid tissue culture that maintains the viability and genotype frequencies between our patients and other functionality of the glands for up to four days; thus, control populations, as other authors have described the response of the gland to long-term effectors such as [20][21][22]. However, Carling et al [23,24] found a higher calcitriol can be studied…”

Vitamin D Receptor Gene Polymorphism and Left Ventricular Hypertrophy in Chronic Kidney Disease

“…Indeed, most studies have been aimed at determining whether VDR polymorphisms could be involved in the development of secondary hyperparathyroidism (sHPT), one of the main complications in patients with CKD. Interestingly, the VDR BsmI b allele was shown to have a higher incidence in HD patients with sHPT and drive the progression toward sHPT in patients with ESRD, since BB individuals had lower levels of PTH and higher calcitriol levels than bb individuals in every stage of CKD [13,14,15,16,17]. Serum PTH levels in CKD patients were also affected by FokI polymorphism, since patients in the FF group had significantly higher PTH levels than those in both the Ff and ff groups, while no significant differences in serum levels of calcidiol or calcium were found among genotypes [18].…”