The BS/BSOB Ratio in Aneuploidy Fetuses at 11-13 Weeks Gestation

Hsiao, Ching Hua; Cheng, Po Jen; Shaw, Steven W.; Tseng, Yin Jiun; Chen, Ran Chou; Chu, Woei Chyn

doi:10.1159/000366020

Cited by 3 publications

(2 citation statements)

References 20 publications

(26 reference statements)

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“…The pathophysiological explanation is still controversial, but an enlargement of the fourth ventricle–CM complex is very often described in these pathologies during the FT as well as non‐visualisation of the choroid plexus of the fourth ventricle 12 . Such changes have been described in some cases of aneuploid fetuses (T13, T18), 45–48 suggesting that these findings may be related to the early onset of oPBD, which is frequent in these conditions.…”

Section: Discussionmentioning

confidence: 99%

Accuracy of qualitative and quantitative cranial ultrasonographic markers in first‐trimester screening for open spina bifida and other posterior brain defects: a systematic review and meta‐analysis

Macé

Mancini

Gorincour

et al. 2020

BJOG

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Main results Twenty-three studies were included in our metaanalysis. The pooled sensitivity and specificity for qualitative assessment were 76.5% and 99.6%, and for quantitative assessment were 84.5% and 96.3%, respectively; specificity for the qualitative ultrasound signs was significantly higher (P = 0.001). The overall sensitivity of cranial sonographic markers for the screening of oPBD was 76.7% and specificity was 97.5%. Conclusions The qualitative approach demonstrated greater specificity, so this would appear to be more appropriate for daily screening, as a first-line tool, whereas the quantitative approach should be reserved for expert ultrasound.

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Section: Discussionmentioning

confidence: 99%

Accuracy of qualitative and quantitative cranial ultrasonographic markers in first‐trimester screening for open spina bifida and other posterior brain defects: a systematic review and meta‐analysis

Macé

Mancini

Gorincour

et al. 2020

BJOG

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“…Moreover, secondary gains of evaluating the PCF during first trimester scans have become apparent. Changes in the BS/BSOB ratio and asymmetry of the posterior brain landmarks may serve as markers for the early diagnosis of fetal abnormalities, such as trisomies, triploidies, and malformations of the PCF (Ferreira et al ; Hsiao et al ; Volpe et al ). These advantages have made posterior brain evaluations more practical and appealing.…”

Section: Introductionmentioning

confidence: 99%

A prospective study on fetal posterior cranial fossa assessment for early detection of open spina bifida at 11–13 weeks

Kose

Altunyurt

Keskįnoğlu

2017

Congenital Anomalies

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The objective of this study was to test three measurements: brain stem (BS), intracranial translucency (IT) and brain stem to occipital bone distance (BSOB), as well as one landmark: cisterna magna (CM) visibility, for early diagnosis of open spina bifida (OSB) in a low risk population. A prospective observational study was undertaken in a university hospital. A sample of 1479 women consented to participate between 20 September 2013 and 30 June 2015. Measurements were performed from the mid-sagittal view, as is routinely used for nuchal thickness assessment. CM visibility was assessed qualitatively as the third anechoic band in the posterior cranial fossa (PCF). All pregnancies were screened with a combination of maternal serum alpha-fetoprotein and second trimester anomaly scan and followed until delivery. Predictive values were calculated for each marker. We were able to diagnose two OSB cases and highly suspect one Dandy-Walker malformation case at the first trimester scan by the observation of PCF. PCF characteristics of OSB cases were increased BS diameter, increased BS-BSOB ratio and non-visualization of the CM. All the markers demonstrated high sensitivity and specificity but CM visibility reached the highest positive predictive value. Due to relatively high false positive rates, PCF measurements could not reach a satisfactory performance to validate their clinical use as a single marker. CM visibility has the advantage of being a qualitative marker and reduces the need for sophisticated and time-consuming measurements. Intracranial translucency and BS-BSOB ratio measurements should be used when the CM visibility is absent or in doubt.

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Is Cisterna Magna Width a Useful First-Trimester Marker of Aneuploidy?

et al. 2019

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Objective: To assess whether the cisterna magna (CM) width measured in first-trimester fetuses is a useful marker for aneuploidy detection. Methods: This was a prospective study in 2 different cohorts in a tertiary referral center. The first cohort comprised 913 fetuses from the general pregnancy population during the period 2012–2016 and was used to construct the CM reference ranges applying the λ-μ-σ (LMS) method. The second cohort included 714 high-risk fetuses undergoing chorionic villus sampling during the period 2012–2016. Mean detection rates using the 95th percentile for CM width observed in chromosomal anomaly groups were compared with those obtained in chromosomally normal fetuses. Results: The 50th percentile for CM ranged from 1.66 to 2.75 mm when crown-rump length (CRL) increased from 45 to 84 mm. Among high-risk fetuses, the following chromosomal anomalies were diagnosed in 125 (17%) fetuses: trisomy 21 (n = 63), trisomy 18 or 13 (n = 21), monosomy X (n = 9), submicroscopic anomalies (n = 11), and other anomalies (n = 22). The mean CM width for euploid fetuses was 2.4 mm (1.13 multiples of the median, MoM). While CM width was significantly increased in trisomy 21 (mean 2.7 mm; 1.23 MoM; p > 0.05), no differences were found in the other anomaly groups. Among the 63 fetuses with trisomy 21, a CM width above the 99th percentile was observed in 23 fetuses (37%). Conclusions: The new reference range for CM width at 11–13 weeks of gestation did not differ from previous studies. In first-trimester fetuses with trisomy 21, CM width appears to be increased, although its value as an ultrasound marker is limited, because of its detection rate of 37%.

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The BS/BSOB Ratio in Aneuploidy Fetuses at 11-13 Weeks Gestation

Cited by 3 publications

References 20 publications

Accuracy of qualitative and quantitative cranial ultrasonographic markers in first‐trimester screening for open spina bifida and other posterior brain defects: a systematic review and meta‐analysis

Accuracy of qualitative and quantitative cranial ultrasonographic markers in first‐trimester screening for open spina bifida and other posterior brain defects: a systematic review and meta‐analysis

A prospective study on fetal posterior cranial fossa assessment for early detection of open spina bifida at 11–13 weeks

Is Cisterna Magna Width a Useful First-Trimester Marker of Aneuploidy?

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