The bronchodilator response as a predictor of inhaled corticosteroid responsiveness in asthmatic children with normal baseline spirometry

Galant, Stanley P.; Morphew, Tricia; Guijon, Olga L.; Pham, Linh

doi:10.1002/ppul.22957

Cited by 15 publications

(17 citation statements)

References 34 publications

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“…A spirometry confirmation required either a predicted percentage of forced expiratory volume in 1 minute of <80%, an FEV 1 /FVC ratio of <0.85, or postbronchodilator improvement of ≥10% in either the FEV 1 or FVC. 43,44…”

Section: Diagnosis Of Asthmamentioning

confidence: 99%

Being Overweight or Obese and the Development of Asthma

et al. 2018

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Adult obesity is linked to asthma cases and is estimated to lead to 250 000 new cases yearly. Similar incidence and attributable risk (AR) estimates have not been developed for children. We sought to describe the relationship between overweight and obesity and incident asthma in childhood and quantify AR statistics in the United States for overweight and obesity on pediatric asthma. METHODS: The PEDSnet clinical data research network was used to conduct a retrospective cohort study (January 2009-December 2015) to compare asthma incidence among overweight and/or obese versus healthy weight 2-to 17-year-old children. Asthma incidence was defined as ≥2 encounters with a diagnosis of asthma and ≥1 asthma controller prescription. Stricter diagnostic criteria involved confirmation by spirometry. We used multivariable Poisson regression analyses to estimate incident asthma rates and risk ratios and accepted formulas for ARs. RESULTS: Data from 507 496 children and 19 581 972 encounters were included. The mean participant observation period was 4 years. The adjusted risk for incident asthma was increased among children who were overweight (relative risk [RR]: 1.17; 95% confidence interval [CI]: 1.10-1.25) and obese (RR: 1.26; 95% CI: 1.18-1.34). The adjusted risk for spirometry-confirmed asthma was increased among children with obesity (RR: 1.29; 95% CI: 1.16-1.42). An estimated 23% to 27% of new asthma cases in children with obesity is directly attributable to obesity. In the absence of overweight and obesity, 10% of all cases of asthma would be avoided. CONCLUSIONS: Obesity is a major preventable risk factor for pediatric asthma.

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Section: Diagnosis Of Asthmamentioning

confidence: 99%

Being Overweight or Obese and the Development of Asthma

et al. 2018

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“…The BDR has been reported to be useful in identifying asthma (60) , those with uncontrolled asthma (61) , ICS responsiveness (62) , and may reflect airway remodeling (63) . In adults the ATS defines a positive BDR as a ≥ 12% and 200ml increase in FEV1, based on the 95% confidence interval BDR value in the general population (64) .…”

Section: Assessing Airway Reactivitymentioning

confidence: 99%

The case for impulse oscillometry in the management of asthma in children and adults

Galant

Komarow

Shin

et al. 2017

Annals of Allergy, Asthma & Immunology

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123

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“…Subjects with asthma show variable response to short-acting b 2 -agonists (bronchodilator response [BDR]) (4). In children, increased BDR has been associated with response to inhaled corticosteroids (ICS) and is often used as a diagnostic tool for asthma (5,6).…”

Section: At a Glance Commentarymentioning

confidence: 99%