The Bronchoconstrictor Action of Bradykinin in the Guinea‐pig

Collier, H. O. J.; Holgate, Jane; Schächter, M; Shorley, Patricia G.

doi:10.1111/j.1476-5381.1960.tb01247.x

Cited by 94 publications

(40 citation statements)

References 6 publications

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“…Ungar (1952) has shown that it is possible to explain the anti-inflammatory action of the antipyretic-analgesic class of drugs on the basis of their anti-fibrinolysin activity, and it could be postulated that the ability of the various analgesic-antipyretic drugs capable of inhibiting formaldehyde-induced inflammation in the mouse foot is due to their anti-fibrinolysin action. Recently, however, Collier, Holgate, Schachter & Shorley (1960) have shown that salicylate is capable of completely inhibiting the action of bradykinin on bronchial smooth muscle in vivo. Since this peptide also causes an increase in capillary permeability, it is possible that the inhibition of formaldehyde-induced inflammation which we have observed is due to an inhibition of the action of bradykinin released by the damaged tissues.…”

Section: Discussionmentioning

confidence: 99%

Some Inhibitors of Histamine‐induced and Formaldehyde‐induced Inflammation in Mice

Northover

Subramanian

1961

British Journal of Pharmacology and Chemotherapy

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The swelling and capillary hyperpermeability of the mouse foot in response to an injection of formaldehyde, and the increased capillary permeability to an intradermal injection of histamine, have been investigated. Cortisone, mepyramine and sodium salicylate were effective in reducing histamine-induced inflammation, sodium salicylate being less active in the adrenalectomized animal. In formaldehyde-induced inflammation, however, cortisone was ineffective whereas sodium salicylate was effective in the intact mouse, but not in the adrenalectomized animal. Certain aryloxypropionates and anti-esterases were also active in reducing the severity of the formaldehydeinduced inflammation.Formaldehyde will induce an inflammatory reaction at the site of injection, and this has been used by Parratt & West (1957) for studying inflammation quantitatively in the rat foot. Selye (1949) first described the effect of injected formaldehyde in the rat foot as an "arthritic " reaction, but this has been criticized by Bourne (1951) as inaccurate. Various authors are agreed, however, upon the main point, that formaldehyde produces a local inflammation.

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Section: Discussionmentioning

confidence: 99%

Some Inhibitors of Histamine‐induced and Formaldehyde‐induced Inflammation in Mice

Northover

Subramanian

1961

British Journal of Pharmacology and Chemotherapy

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“…The details of the modifications that result in simplification and improved sensitivity fi-Adrenoceptor blockade and air overflow are described in the Appendix to this paper. Increases in air overflow were produced by intravenous injections of methacholine or histamine, and rapid recovery was effected by occluding the overflow tube for a time, as suggested by Collier, Holgate, Schachter & Shorley (1960). The animals were always bilaterally vagotomized as this improved the regularity of response.…”

Section: Methodsmentioning

confidence: 99%

Effect of β‐adrenoceptive blocking agents on the response to bronchoconstrictor drugs in the guinea‐pig air overflow preparation

Burden¹,

Parkes²,

Gardiner³

1971

British J Pharmacology

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Summary Propranolol augmented the bronchoconstrictor response to methacholine or histamine, recorded by air overflow in the anaesthetized, vagotomized guinea‐pig. After adrenalectomy, propranolol was still active, though less so than before. In the pithed guinea‐pig, there was no augmentation of the effect of bronchoconstrictors on air overflow. The action of propranolol could thus be due to the β‐adrenoceptor blockade of compensatory sympathetic bronchodilator activity, as concluded by McCulloch, Proctor & Rand (1967). Electrical stimulation of the thoracic region of the spinal cord of the pithed guinea‐pig reduced the effect of bronchoconstrictors on air overflow. This reduction could be blocked by propranolol; practolol was much less effective.

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“…One possibility that we have considered is that these compounds inhibit the activity of a plasma kinin-forming enzyme system or act as antagonists of plasma kinin. Collier, Holgate, Schachter & Shorley (1960) have reported that salicylates inhibit the bronchoconstrictor action of bradykinin, and we have shown (Northover & Subramanian, 1961b) that salicylates and other analgesic-antipyretic drugs inhibit plasma kallikrein, which is a plasma kinin-forming enzyme. There are two reasons for thinking, however, that plasma kinin is not an important mediator in the reaction of the mouse foot to formaldehyde.…”

Section: Discussionmentioning

confidence: 99%

A Study of Possible Mediators of Inflammatory Reactions in the Mouse Foot

Northover

Subramanian

1962

British Journal of Pharmacology and Chemotherapy

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A number of compounds have been studied for their ability to antagonize the inflammatory reaction produced by injections of formaldehyde and 5-hydroxytryptamine in the mouse foot. An attempt has been made to elucidate the ways in which certain hydroxybenzoates, pyrazolones, sympathomimetic amines, flavone and flavanone glycosides, local anaesthetics, antihistamines and anti-5-hydroxytryptamine substances produce their anti-inflammatory effect.Several substances occur in damaged tissues which have the ability to increase capillary permeability, the subject having been reviewed by Spector (1958). The presence of such substances does not prove their participation in the mediation of the symptoms observed, and it is difficult to differentiate between the causes and the effects of the process in many types of inflammation. Since Lewis (1927) demonstrated that part of the response of tissues to trauma is mediated by an axon-reflex there has been little work done to discover to what extent this process operates in different types of inflammation. Chambers & Zweifach (1947) have emphasized that little is known about the effect which local changes in blood flow have on the overall inflammatory reaction, and so we have attempted, in the experiments described here, to analyse the anti-inflammatory action of certain drugs which are known to alter blood flow in the skin. METHODSFormaldehyde-induced inflammation in the mouse foot. The details of the method have been described by Northover & Subramanian (1961a). Adult mice of either sex weighing between 25 and 35 g were used in groups of 6 animals. The animals were pretreated with the test substance, given subcutaneously, one injection 24 hr and another 30 min before the injection of formaldehyde. Where variations of this procedure were used they are indicated in the text. All premedicant injections were made in a dose-volume of 0.1 ml., and all compounds were given either as freshly prepared solutions or suspensions, adjusted, where required, to pH 7 with either sodium hydroxide or hydrochloric acid. Each mouse received 0.1 ml. of an aqueous solution containing 0.5% azovan blue and 0.9% sodium chloride through a lateral tail vein, and then immediately afterwards 0.05 ml. of an aqueous solution containing 4% formaldehyde and 0.9% sodium chloride subcutaneously in the dorsum of the right hind foot. The left hind foot received the same volume of saline alone and acted as a control for the formaldehyde-treated foot. The blue-dye accumulation and the swelling in the test foot compared with the control foot were given subjectively assigned scores of from 0 to 3 by

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The Bronchoconstrictor Action of Bradykinin in the Guinea‐pig

Cited by 94 publications

References 6 publications

Some Inhibitors of Histamine‐induced and Formaldehyde‐induced Inflammation in Mice

Some Inhibitors of Histamine‐induced and Formaldehyde‐induced Inflammation in Mice

Effect of β‐adrenoceptive blocking agents on the response to bronchoconstrictor drugs in the guinea‐pig air overflow preparation

A Study of Possible Mediators of Inflammatory Reactions in the Mouse Foot

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