The Bronchial Glands in Aging*

Hernández, José Ángel; Anderson, A. E.; Holmes, Whitney L.; Morrone, Nelson; Foraker, Alvan G.

doi:10.1111/j.1532-5415.1965.tb02060.x

Cited by 14 publications

(3 citation statements)

References 8 publications

(14 reference statements)

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“…Our efforts also demonstrate that Wnt ligands are secreted in the uninjured aged airway, thereby further emphasizing the dynamic character of the niche. Further, the similarity between the morphology of the GLEIs and the structures in young mice with hyperactive b-catenin in K5 + ABSCs suggests that Wnt gradients in the ICZ and overlying SAE may play a role in the glandular hypertrophy previously appreciated during aging (Hernandez et al, 1965). Our efforts also revealed that GLEIs arise from K5 + ABSCs that are labeled during youth, suggesting ABSC migration during aging.…”

Section: Discussionsupporting

confidence: 53%

Distinct Spatiotemporally Dynamic Wnt-Secreting Niches Regulate Proximal Airway Regeneration and Aging

et al. 2020

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Section: Discussionsupporting

confidence: 53%

Distinct Spatiotemporally Dynamic Wnt-Secreting Niches Regulate Proximal Airway Regeneration and Aging

et al. 2020

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“…Alveolar ectasia, thinning of the alveolar septum, a decrease of elastic fibers (20), and hypertrophy of the bronchial glands (21) are seen in the lungs of elderly persons. These changes were present in almost every lung in our series, and some of them overlapped the changes ascribed to emphysema.…”

Section: Discussionmentioning

confidence: 99%

Pathology of Centenarians. I. The Cardiovascular System and Lungs

Ishii

Sternby

1978

J American Geriatrics Society

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The cardiovascular and lung lesions in 23 centenarians (7 males and 16 females) were examined pathologically. The heart showed varied degrees of hypertrophy, and myocardial fibrosis was present in 15 of the 23 patients. Coronary arteriosclerosis was noted coincidentally. In addition to these findings, amyloid deposition was seen in the hearts of 8 patients. Generalized atherosclerosis of the arterial tree was severe to moderate in all cases. Bronchopneumonia was present in 15 of the 23 patients, and fresh or old thromboembolism in 8. There was a tendency toward emphysema and chronic bronchitis in the structure of the lung. The frequent occurrence of myocardial fibrosis and bronchopneumonia was characteristic in the series. It was significant that cardiac amyloid deposition was noted in these cases.

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“…These changes contribute to a decreased surface area available for gas exchange. Additionally, an increase in the work of breathing occurs due to increased rigidity of the conducting tubules, changes in smooth muscle structure, and increased thickness of the mucosal bed 112,113 .…”

Section: Anatomic and Physiologic Changesmentioning

confidence: 99%

Issues in aging in individuals with life long disabilities

Connolly¹

2006

Rev. bras. fisioter.

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Introduction: The major research data and findings related to aging among persons with developmental disabilities are discussed. Topics addressed include prevalence and mortality rates, as well as the effects of aging on the sensory systems, the neuromusculoskeletal system and the cardiopulmonary system. The discussion also focuses on the clinical implications of these changes among aging individuals with developmental disabilities. Conclusion: Although the individual needs of persons with developmental disabilities vary greatly, knowledge of the effects of aging on this group of individuals can facilitate more effective healthcare by physical therapists for all adults with developmental disabilities.

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The Bronchial Glands in Aging*

Cited by 14 publications

References 8 publications

Distinct Spatiotemporally Dynamic Wnt-Secreting Niches Regulate Proximal Airway Regeneration and Aging

Distinct Spatiotemporally Dynamic Wnt-Secreting Niches Regulate Proximal Airway Regeneration and Aging

Pathology of Centenarians. I. The Cardiovascular System and Lungs

Issues in aging in individuals with life long disabilities

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