The Brompton Mixture

Melzack, Ronald; Ofiesh, John; Mount, Balfour M.

doi:10.1097/00132586-197902000-00016

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“…Pharmacological data clearly show that combination of cocaine with morphine produces an enhanced effect relative that of each drug per se [2,44] and/or may change the toxicity profile of the isolated drugs [2,45,46]. There is, in addition, clinical evidence (although arguable) of a particular activity of the cocaine-morphine combination (Brompton mixture) against chronic pain [47]. For the cocaine-heroin mixture it was found that each drug act largely per se.…”

Section: Resultsmentioning

confidence: 99%

Spectroscopic and electrochemical studies of cocaine–opioid interactions

et al. 2007

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The drugs of abuse cocaine (C), heroin (H), and morphine (M) have been studied to enable understanding of the occurrence of cocaine-opioid interactions at a molecular level. Electrochemical, Raman, and NMR studies of the free drugs and their mixtures were used to study drug-drug interactions. The results were analyzed using data obtained from quantum-mechanical calculations. For the cocaine-morphine mixture (C-MH), formation of a binary complex was detected; this involved the 3-phenolic group and the heterocyclic oxygen of morphine and the carbonyl oxygen and the methyl protons of cocaine's methyl ester group. NMR studies conducted simultaneously also revealed C-MH binding geometry consistent with theoretical predictions and with electrochemical and vibrational spectroscopy results. These results provide evidence for the occurrence of a cocaine-morphine interaction, both in the solid state and in solution, particularly for the hydrochloride form. A slight interaction, in solution, was also detected by NMR for the cocaine-heroin mixture.

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