The brominated flame retardants TBECH and DPTE alter prostate growth, histology and gene expression patterns in the mouse

Polymorphism of SERF2, the gene encoding a heat-resistant obscure (Hero) protein with chaperone activity, is a novel link in ischemic stroke

“…Revealed sensitivity to mutation for only women and non-smokers may be theoretically related to abolishment of protective effects of the A allele for males and smokers who are more prone to cardiovascular diseases. However, previous data show that in contract to estrogens ( Gertz et al, 2012 ) tobacco components ( [44] , [26] , [22] ) and androgens ( Bereketoglu et al, 2021 ) serve positive regulators of SERF2 expression making a hint that these sex/smoking-gene relationships may still be explained by cellular effects of SERF2 only. Taking together our data suggest that SERF2 has a protective role because the factors increasing its expression (male sex, smoking, A allele) decrease the risk of IS.…”