The Broad-Spectrum Antimicrobial Potential of [Mn(CO)4(S2CNMe(CH2CO2H))], a Water-Soluble CO-Releasing Molecule (CORM-401): Intracellular Accumulation, Transcriptomic and Statistical Analyses, and Membrane Polarization

Wareham, Lauren K.; Mclean, Simon; Begg, Ronald; Rana, Namrata; Ali, Salar Ibrahim; Kendall, John J.; Sanguinetti, Guido; Mann, Brian E.; Poole, Robert K.

doi:10.1089/ars.2017.7239

Cited by 23 publications

(18 citation statements)

References 70 publications

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“…Furthermore, complex 19 exhibited a cytostatic effect in the dark and cytotoxic effect if exposed to light against S. aureus. Mann et al introduced molecule 20 and studied the broad-spectrum antimicrobial potential of the molecules [70,71]…”

Section: Manganese Photoactivatable Co-releasing Molecules (Photocorms)mentioning

confidence: 99%

Recent Studies on the Antimicrobial Activity of Transition Metal Complexes of Groups 6–12

Sovari

Zobi

2020

Chemistry

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Antimicrobial resistance is an increasingly serious threat to global public health that requires innovative solutions to counteract new resistance mechanisms emerging and spreading globally in infectious pathogens. Classic organic antibiotics are rapidly exhausting the structural variations available for an effective antimicrobial drug and new compounds emerging from the industrial pharmaceutical pipeline will likely have a short-term and limited impact before the pathogens can adapt. Inorganic and organometallic complexes offer the opportunity to discover and develop new active antimicrobial agents by exploiting their wide range of three-dimensional geometries and virtually infinite design possibilities that can affect their substitution kinetics, charge, lipophilicity, biological targets and modes of action. This review describes recent studies on the antimicrobial activity of transition metal complexes of groups 6–12. It focuses on the effectiveness of the metal complexes in relation to the rich structural chemical variations of the same. The aim is to provide a short vade mecum for the readers interested in the subject that can complement other reviews.

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Section: Manganese Photoactivatable Co-releasing Molecules (Photocorms)mentioning

confidence: 99%

Recent Studies on the Antimicrobial Activity of Transition Metal Complexes of Groups 6–12

Sovari

Zobi

2020

Chemistry

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“…Importantly, CORMs were shown to be more potent bactericides than CO gas due to the accumulation of CORMs inside bacterial cells . Mechanisms underlying the antimicrobial effect of CORMs presumably involve the inhibition of bacterial respiratory chain, the enhancement of reactive oxygen species (ROS) generation, the increase of membrane polarization, and the interference of gene expression, etc. Overall, these results revealed that CO administration may be a useful intervention in microbial infections.…”

Section: The Application Of Co In Disease Therapymentioning

confidence: 99%

Emerging Delivery Strategies of Carbon Monoxide for Therapeutic Applications: from CO Gas to CO Releasing Nanomaterials

Yan

Zhu

et al. 2019

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Carbon monoxide (CO) therapy has emerged as a hot topic under exploration in the field of gas therapy as it shows the promise of treating various diseases. Due to the gaseous property and the high affinity for human hemoglobin, the main challenges of administrating medicinal CO are the lack of target selectivity as well as the toxic profile at relatively high concentrations. Although abundant CO releasing molecules (CORMs) with the capacity to deliver CO in biological systems have been developed, several disadvantages related to CORMs, including random diffusion, poor solubility, potential toxicity, and lack of on‐demand CO release in deep tissue, still confine their practical use. Recently, the advent of versatile nanomedicine has provided a promising chance for improving the properties of naked CORMs and simultaneously realizing the therapeutic applications of CO. This review presents a brief summarization of the emerging delivery strategies of CO based on nanomaterials for therapeutic application. First, an introduction covering the therapeutic roles of CO and several frequently used CORMs is provided. Then, recent advancements in the synthesis and application of versatile CO releasing nanomaterials are elaborated. Finally, the current challenges and future directions of these important delivery strategies are proposed.

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“…The side effects of CORMs are unfortunately not restricted to ruthenium-based compounds. Manganese-containing CORM-401 stimulates respiration, depolarizes the cytoplasmic membrane in a manner similar to uncouplers, and elicits the loss of intracellular potassium in E. coli cells [ 100 ]. These properties could explain the increase of the oxygen consumption rate (OCR) in intact mitochondria [ 70 ] in the manner independent from the activation of mitoBK Ca .…”

Section: Carbon Monoxidementioning

confidence: 99%

Gas Signaling Molecules and Mitochondrial Potassium Channels

Walewska

Szewczyk

Koprowski

2018

IJMS

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Recently, gaseous signaling molecules, such as carbon monoxide (CO), nitric oxide (NO), and hydrogen sulfide (H2S), which were previously considered to be highly toxic, have been of increasing interest due to their beneficial effects at low concentrations. These so-called gasotransmitters affect many cellular processes, such as apoptosis, proliferation, cytoprotection, oxygen sensing, ATP synthesis, and cellular respiration. It is thought that mitochondria, specifically their respiratory complexes, constitute an important target for these gases. On the other hand, increasing evidence of a cytoprotective role for mitochondrial potassium channels provides motivation for the analysis of the role of gasotransmitters in the regulation of channel function. A number of potassium channels have been shown to exhibit activity within the inner mitochondrial membrane, including ATP-sensitive potassium channels, Ca2+-activated potassium channels, voltage-gated Kv potassium channels, and TWIK-related acid-sensitive K+ channel 3 (TASK-3). The effects of these channels include the regulation of mitochondrial respiration and membrane potential. Additionally, they may modulate the synthesis of reactive oxygen species within mitochondria. The opening of mitochondrial potassium channels is believed to induce cytoprotection, while channel inhibition may facilitate cell death. The molecular mechanisms underlying the action of gasotransmitters are complex. In this review, we focus on the molecular mechanisms underlying the action of H2S, NO, and CO on potassium channels present within mitochondria.

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The Broad-Spectrum Antimicrobial Potential of [Mn(CO)₄(S₂CNMe(CH₂CO₂H))], a Water-Soluble CO-Releasing Molecule (CORM-401): Intracellular Accumulation, Transcriptomic and Statistical Analyses, and Membrane Polarization

Cited by 23 publications

References 70 publications

Recent Studies on the Antimicrobial Activity of Transition Metal Complexes of Groups 6–12

Recent Studies on the Antimicrobial Activity of Transition Metal Complexes of Groups 6–12

Emerging Delivery Strategies of Carbon Monoxide for Therapeutic Applications: from CO Gas to CO Releasing Nanomaterials

Gas Signaling Molecules and Mitochondrial Potassium Channels

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