The Broad-Spectrum Activity and Efficacy of Catheters Coated with Minocycline and Rifampin

Raad, Issam; Darouiche, Rabih O.; Hachem, Ray; Mansouri, Mohammad D.; Bodey, Gerald P.

doi:10.1093/infdis/173.2.418

Cited by 241 publications

(124 citation statements)

References 33 publications

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“…However, in vitro data indicate that these impregnated catheters could increase the incidence of minocycline and rifampin resistance among pathogens, especially staphylococci. The half-life of antimicrobial activity against S. epidermidis is 25 days with catheters coated with minocycline/rifampin, compared with 3 days for the first-generation catheters coated with chlorhexidine/silver sulfadiazine in vitro [87]. In vivo, the duration of antimicrobial activity of the minocycline/rifampin catheter is longer than that of the first-generation chlorhexidine/silver sulfadiazine catheter [91].…”

Section: Antimicrobial/antiseptic Impregnated Catheters and Cuffsmentioning

confidence: 99%

“…The mean duration of catheter placement in one metaanalysis ranged from 5.1 to 11.2 days [86]. The half-life of antimicrobial activity against S. epidermidis is 3 days in vitro for catheters coated with chlorhexidine/silver sulfadiazine; this antimicrobial activity decreases over time [87]. The benefit for the patients who receive these catheters will be realized within the first 14 days [86].…”

Section: Antimicrobial/antiseptic Impregnated Catheters and Cuffsmentioning

confidence: 99%

See 1 more Smart Citation

Guidelines for the prevention of intravascular catheter-related infections

O’Grady¹,

Alexander²,

Dellinger³

et al. 2002

American Journal of Infection Control

635

843

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These guidelines have been developed for practitioners who insert catheters and for persons responsible for surveillance and control of infections in hospital, outpatient, and home health-care settings. This report was prepared by a working group comprising members from professional organizations representing the disciplines of critical care medicine, infectious diseases, health-care infection control, surgery, anesthesiology, interventional radiology, pulmonary medicine, pediatric medicine, and nursing. The These guidelines are intended to provide evidencebased recommendations for preventing catheter-related infections. Major areas of emphasis include 1) educating and training health-care providers who insert and maintain catheters; 2) using maximal sterile barrier precautions during central venous catheter insertion; 3) using a 2% chlorhexidine preparation for skin antisepsis; 4) avoiding routine replacement of central venous catheters as a strategy to prevent infection; and 5) using antiseptic/antibiotic impregnated short-term central venous catheters if the rate of infection is high despite adherence to other strategies (i.e., education and training, maximal sterile barrier precautions, and 2% chlorhexidine for skin antisepsis). These guidelines also identify performance indicators that can be used locally by health-care institutions or organizations to monitor their success in implementing these evidence-based recommendations.

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Section: Antimicrobial/antiseptic Impregnated Catheters and Cuffsmentioning

confidence: 99%

Section: Antimicrobial/antiseptic Impregnated Catheters and Cuffsmentioning

confidence: 99%

Guidelines for the prevention of intravascular catheter-related infections

O’Grady¹,

Alexander²,

Dellinger³

et al. 2002

American Journal of Infection Control

635

843

View full text Add to dashboard Cite

show abstract

“…In the last decade, several strategies to control biofilm growth on medical devices have been suggested, including the use of topical antimicrobial ointments, minimizing the length of time of catheterization, using catheters provided with a surgically implanted cuff (9), and coating the catheter lumen with antimicrobial agents (1,6,23,24,25,29,30,32,39). Existing antimicrobial-loaded catheters suffer from a number of limitations, including the rapid release of the adsorbed antibiotic in the first hours after implantation and, as a result, a relatively short persistence of antibacterial action (7).…”

mentioning

confidence: 99%

Usnic Acid, a Natural Antimicrobial Agent Able To Inhibit Bacterial Biofilm Formation on Polymer Surfaces

Francolini

Norris

Piozzi

et al. 2004

Antimicrob Agents Chemother

235

166

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In modern medicine, artificial devices are used for repair or replacement of damaged parts of the body, delivery of drugs, and monitoring the status of critically ill patients. However, artificial surfaces are often susceptible to colonization by bacteria and fungi. Once microorganisms have adhered to the surface, they can form biofilms, resulting in highly resistant local or systemic infections. At this time, the evidence suggests that (؉)-usnic acid, a secondary lichen metabolite, possesses antimicrobial activity against a number of planktonic gram-positive bacteria, including Staphylococcus aureus, Enterococcus faecalis, and Enterococcus faecium. Since lichens are surface-attached communities that produce antibiotics, including usnic acid, to protect themselves from colonization by other bacteria, we hypothesized that the mode of action of usnic acid may be utilized in the control of medical biofilms. We loaded (؉)-usnic acid into modified polyurethane and quantitatively assessed the capacity of (؉)-usnic acid to control biofilm formation by either S. aureus or Pseudomonas aeruginosa under laminar flow conditions by using image analysis. (؉)-Usnic acid-loaded polymers did not inhibit the initial attachment of S. aureus cells, but killing the attached cells resulted in the inhibition of biofilm. Interestingly, although P. aeruginosa biofilms did form on the surface of (؉)-usnic acid-loaded polymer, the morphology of the biofilm was altered, possibly indicating that (؉)-usnic acid interfered with signaling pathways.

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“…Raad et al 28 found that the rifampin-minocycline combination also displayed broad-spectrum inhibitory activity against Gram-negative bacteria and yeast cells. Raad et al 29 suggested that an advantage of the combination of minocycline and rifampin is that they are not used as primary agents in the treatment of systemic infections.…”

Section: Infection Preventionmentioning

confidence: 99%

“…29 In subsequent clinical studies with central venous catheters, Raad et al 30 found that rifampin-minocycline-coated catheters significantly reduced the risk for catheter-related colonization and bloodstream infections. Bacterial colonization occurred with 26% of uncoated catheters compared with 8% of catheters coated with minocycline and rifampin (Po0.01).…”

Section: Infection Preventionmentioning

confidence: 99%

Diagnosis, treatment and prevention of penile prosthesis infection

Carson

2003

Int J Impot Res

129

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The implantation of inflatable penile prostheses for the treatment of erectile dysfunction continues to be widely practiced in the United States and internationally. As third-line therapy for erectile dysfunction, the numbers of implants continue to rise as the population of men treated for erectile dysfunction increases. Complications of penile prosthesis implantation continued to decline as mechanical malfunctions have decreased as a result of re-engineering inflatable penile prostheses. Inflatable penile prostheses from both available vendors continue to be reliable, effective methods for restoring erectile function with high satisfaction rates. The most troublesome complication of these prostheses, however, is not mechanical but rather that of prosthesis infection. Prosthesis infections may result in further surgery, loss of penile tissue, and even the inability to replace penile prosthesis. While standard sterile technique perioperative antibiotics and careful surgical procedures continue to be the cornerstone of penile prosthesis infection avoidance, newer designs of penile prostheses for antibiotic coating have resulted in an improvement in the prevalence and incidents of penile prosthesis infection. For those patients in whom penile prostheses become infected despite adequate prophylaxis, newer techniques of salvage have demonstrated increasing success. Once and still the most dreaded complication of penile prosthesis implantation, prothesis infections can now be avoided by perioperative preparation and antibiotics as well as antibioticcoated penile prostheses. Treatment of penile prosthesis infections once associated with severe loss of function can often be successful with modern salvage techniques. Implanting urologists must be familiar prophylaxis, avoidance, and treatment of penile prosthesis infections.

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The Broad-Spectrum Activity and Efficacy of Catheters Coated with Minocycline and Rifampin

Cited by 241 publications

References 33 publications

Guidelines for the prevention of intravascular catheter-related infections

Guidelines for the prevention of intravascular catheter-related infections

Usnic Acid, a Natural Antimicrobial Agent Able To Inhibit Bacterial Biofilm Formation on Polymer Surfaces

Diagnosis, treatment and prevention of penile prosthesis infection

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