The bright side of sound: perspectives on the biomedical application of sonoluminescence

Canaparo, Roberto; Foglietta, Federica; Giuntini, Francesca; Francovich, Andrea; Serpe, Loredana

doi:10.1039/d0pp00133c

Cited by 20 publications

(18 citation statements)

References 67 publications

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“…Thereafter SDT cytotoxicity was evaluated confirming that SDT, i.e., 4T1 cells cultured with C-doped TiO 2 NPs and subjected to US exposure, induced higher cytotoxicity in 4T1 cells than the other treatment groups. Interesting was the speculation about the possible pathway of cell damage induced by SDT, where the authors suggested a role of sonoluminescence in the C-doped TiO 2 NPs activation to generate more ROS and kill 4T1 breast cancer cells [96]. Finally, in this work, to further investigate the cell death of 4T1 cells induced by SDT, an in vivo study was performed.…”

Section: Titanium Dioxide Npsmentioning

confidence: 99%

“…In this pioneering in vitro work, the role of targeted AuNps as sonosensitizers in SDT, an innovative anticancer approach where, it is generally accepted, a non-toxic molecule or system (chemical actuator), i.e., the sonosensitizer, is activated by US (physical activator), yielding oxidative damage by ROS generation, and consequent cancer cell death [94,95]. More specifically, the authors suggest that US, used at the frequency of 1.866 MHz for a total 5 min of exposure, through a physical phenomenon called sonoluminescence [96], might drive the AuNPs' plasmonic effect, as derived from LSPR, to be able to convert the photon energy to heat in order to induce cellular damage via ROS production. Analysis of intracellular ROS production was investigated in two different cell lines, HCT-116 and KB, and demonstrated that, while cells incubated with AuNPs in the absence of US and US alone did not encounter an increase in intracellular ROS productions, cells that were exposed to both AuNPs and US, i.e., sonodynamic treatment, were subjected to a significant increase in ROS production and therefore enhanced death rates.…”

Section: Gold Npsmentioning

confidence: 99%

“…Another possibility to excite ZnONPs in aqueous solutions is the application of US, as propagation in a liquid milieu causes the well-known physical phenomenon called acoustic cavitation. A number of secondary effects are determined by this phenomenon, and in particular sonoluminescence, which represents a sonoluminescent emission, mainly a UV light, due to the cavitation bubble implosion [96]. For this reason, many researchers suggest that ZnONPs bring about cytotoxic effects when exposed to US via generation of ROS as their principal mechanism of bacterial and cancerous cell death [108].…”

Section: Zinc Oxide Npsmentioning

confidence: 99%

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Biomedical Applications of Reactive Oxygen Species Generation by Metal Nanoparticles

et al. 2020

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The design, synthesis and characterization of new nanomaterials represents one of the most dynamic and transversal aspects of nanotechnology applications in the biomedical field. New synthetic and engineering improvements allow the design of a wide range of biocompatible nanostructured materials (NSMs) and nanoparticles (NPs) which, with or without additional chemical and/or biomolecular surface modifications, are more frequently employed in applications for successful diagnostic, drug delivery and therapeutic procedures. Metal-based nanoparticles (MNPs) including metal NPs, metal oxide NPs, quantum dots (QDs) and magnetic NPs, thanks to their physical and chemical properties have gained much traction for their functional use in biomedicine. In this review it is highlighted how the generation of reactive oxygen species (ROS), which in many respects could be considered a negative aspect of the interaction of MNPs with biological matter, may be a surprising nanotechnology weapon. From the exchange of knowledge between branches such as materials science, nanotechnology, engineering, biochemistry and medicine, researchers and clinicians are setting and standardizing treatments by tuning ROS production to induce cancer or microbial cell death.

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Section: Titanium Dioxide Npsmentioning

confidence: 99%

Section: Gold Npsmentioning

confidence: 99%

Section: Zinc Oxide Npsmentioning

confidence: 99%

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Biomedical Applications of Reactive Oxygen Species Generation by Metal Nanoparticles

et al. 2020

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“…Porphyrins are well-known photosensitizers as their tetrapyrrole ring structure can be activated by light to generate ROS, causing damage to cell structures and cell death [33]. These features also make porphyrins also suitable sonosensitizers, i.e., compounds responsive to US, due to the hypothesis of the sonoluminescence occurrence under appropriate US exposure [34].…”

Section: Discussionmentioning

confidence: 99%

Sonodynamic Treatment Induces Selective Killing of Cancer Cells in an In Vitro Co-Culture Model

Foglietta

Pinnelli

Giuntini

et al. 2021

Cancers

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Sonodynamic Therapy (SDT) is a new anticancer strategy based on ultrasound (US) technique and is derived from photodynamic therapy (PDT); SDT is still, however, far from clinical application. In order to move this therapy forward from bench to bedside, investigations have been focused on treatment selectivity between cancer cells and normal cells. As a result, the effects of the porphyrin activation by SDT on cancer (HT-29) and normal (HDF 106-05) cells were studied in a co-culture evaluating cell cytotoxicity, reactive oxygen species (ROS) production, mitochondrial function and plasma membrane fluidity according to the bilayer sonophore (BLS) theory. While PDT induced similar effects on both HT-29 and HDF 106-05 cells in co-culture, SDT elicited significant cytotoxicity, ROS production and mitochondrial impairment on HT-29 cells only, whereas HDF 106-05 cells were unaffected. Notably, HT-29 and HDF 106-05 showed different cell membrane fluidity during US exposure. In conclusion, our data demonstrate a marked difference between cancer cells and normal cells in co-culture in term of responsiveness to SDT, suggesting that this different behavior can be ascribed to diversity in plasma membrane properties, such as membrane fluidity, according to the BLS theory.

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“…In sonodynamic therapy in which certain classes of drug can be activated by ultrasound, it has been suggested that MBSL light activates photosensitive drug [ 96 , 97 ]. Further studies are required on this topic.…”

Section: Applications Of Mbslmentioning

confidence: 99%

Multibubble Sonoluminescence from a Theoretical Perspective

Yasui

2021

Molecules

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In the present review, complexity in multibubble sonoluminescence (MBSL) is discussed. At relatively low ultrasonic frequency, a cavitation bubble is filled mostly with water vapor at relatively high acoustic amplitude which results in OH-line emission by chemiluminescence as well as emissions from weakly ionized plasma formed inside a bubble at the end of the violent bubble collapse. At relatively high ultrasonic frequency or at relatively low acoustic amplitude at relatively low ultrasonic frequency, a cavitation bubble is mostly filled with noncondensable gases such as air or argon at the end of the bubble collapse, which results in relatively high bubble temperature and light emissions from plasma formed inside a bubble. Ionization potential lowering for atoms and molecules occurs due to the extremely high density inside a bubble at the end of the violent bubble collapse, which is one of the main reasons for the plasma formation inside a bubble in addition to the high bubble temperature due to quasi-adiabatic compression of a bubble, where “quasi” means that appreciable thermal conduction takes place between the heated interior of a bubble and the surrounding liquid. Due to bubble–bubble interaction, liquid droplets enter bubbles at the bubble collapse, which results in sodium-line emission.

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The bright side of sound: perspectives on the biomedical application of sonoluminescence

Abstract: Light is a physical phenomenon that is very important to human life, and has been investigated in its nature, behaviour and properties throughout human history although the most impressive improvements...

Cited by 20 publications

References 67 publications

Biomedical Applications of Reactive Oxygen Species Generation by Metal Nanoparticles

Biomedical Applications of Reactive Oxygen Species Generation by Metal Nanoparticles

Sonodynamic Treatment Induces Selective Killing of Cancer Cells in an In Vitro Co-Culture Model

Multibubble Sonoluminescence from a Theoretical Perspective

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