The breathtaking world of human respiratory in vitro models: Investigating lung diseases and infections in 3D models, organoids, and lung‐on‐chip
Stefanie Dichtl,
Wilfried Posch*,
Doris Wilflingseder
Abstract:The COVID‐19 pandemic illustrated an urgent need for sophisticated, human tissue models to rapidly test and develop effective treatment options against this newly emerging severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2). Thus, in particular, the last 3 years faced an extensive boost in respiratory and pulmonary model development. Nowadays, 3D models, organoids and lung‐on‐chip, respiratory models in perfusion, or precision‐cut lung slices are used to study complex research questions in human prima… Show more
This review focuses on the impact of cell types and other experimental factors such as exposure duration, dose, chemical composition, and atmospheric processing of PM, on the results of cell-based assays.
This review focuses on the impact of cell types and other experimental factors such as exposure duration, dose, chemical composition, and atmospheric processing of PM, on the results of cell-based assays.
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