The breast lesion excision system (BLES): a novel technique in the diagnostic and therapeutic management of small indeterminate breast lesions?

Abstract

The BLES biopsy is an efficacious technique at excising small indeterminate breast lesions with a complete margin without the need for follow-up diagnostic surgery in the majority.

Percutaneous removal of sentinel lymph nodes in a swine model using a breast lesion excision system and contrast-enhanced ultrasound

“…Percutaneous large core biopsy techniques are already in use in the removal of benign or borderline breast lesions. Previous publications have reported the safe use of the Intact® breast lesion excision system in breast [27,28]. To our knowledge, this is the first study in an experimental setting describing the feasibility of percutaneous removal of the entire, intact SLN using CEUS.…”

A systematic review on the use of the Breast Lesion Excision System in breast disease

“…Five hundred eighteen articles were excluded because they did not use the BLES device or a prototype. We identified 19 full-text versions of studies that used the BLES as a diagnostic or therapeutic device and that fulfilled all the inclusion criteria [4][5][6][7][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23]. Figure 3 shows the results of the study search and identification of eligible studies.…”

“…As opposed to other breast biopsy devices, the aim of BLES is to excise and retrieve an intact breast tissue specimen, rather than to obtain fragmented samples [4][5][6][7], which may not only facilitate easier diagnosis but also might allow for minimally invasive resections.…”

The Intact® breast lesion excision system as a therapeutic device for selected benign breast lesions

“…This is an automated single‐pass biopsy instrument utilizing radiofrequency (RF) under stereotactic OR US guidance designed to provide excision of breast tissue as a single intact specimen and potentially producing a sample of sufficient size with preserved architecture for diagnosis and possible margin evaluation . The BLES technique also may have a selected therapeutic role for definitive specimen excision of benign or borderline lesions and the avoidance of a traditional surgical excision . Preliminary work has shown promising results, with DCIS underestimation rates using the device ranging between 3%‐21% and complete excision rates for malignant lesions of between 39%‐66% overall .…”

“…8,9 The BLES technique also may have a selected therapeutic role for definitive specimen excision of benign or borderline lesions and the avoidance of a traditional surgical excision. [10][11][12] Preliminary work has shown promising results, with DCIS underestimation rates using the device ranging between 3%-21% 8,12,13 and complete excision rates for malignant lesions of between 39%-66% overall. 10,12 The aim of this paper is to evaluate our Unit's initial experience using the Intact â system specifically as a therapeutic excision option for benign or borderline breast lesions, which otherwise would entail open operative excision.…”