Key Points
Question
Do rural and urban patients with cancer receiving similar care in clinical trials have similar outcomes?
Findings
In this comparative effectiveness study, 36 995 patients from all 50 states enrolled in 44 SWOG treatment trials from 1986 to 2012, composing 17 different cancer-specific analysis cohorts, were examined. Rural patients had statistically significantly worse survival in only 1 of the 17 analysis cohorts (those with adjuvant-stage, estrogen receptor–negative and progesterone receptor–negative breast cancer) irrespective of how rural residency was defined.
Meaning
Improving access to uniform treatment strategies such as those found in clinical trials may help resolve the disparity in cancer outcomes between rural and urban patients.