This study examined the relationship between predictors such as demographical aspect, task characteristics, physical demands, work-life balance, workstyle, psychosocial factors, and MSDs among firefighters conducted at four fire stations under Kota Kinabalu Zone in Sabah (n=130). The questionnaires used in the present study consist of a demographical aspect, task characteristics scale, physical demands scale, work-life balance scale, workstyle scale, Work Organization Assessment Questionnaire, Mental Health Scale, and musculoskeletal disorders (MSDs). The data were analysed with the use of SPSS version 22.0. The results show that task characteristics, physical demands, work-life balance, workstyle, and Mental Health Scale were significantly related to MSDs among Kota Kinabalu, Sabah firefighters. While age and gender did not relate to MSDs. In addition, there was no relationship between other factors such as psychosocial factors and work-life balance on MSDs. Firefighters did experience MSD due to overweighted equipment, lack of rest, accidents, and traumatic events like death among victims or teammates, leading to depression and stress.