The Brazilian Amaryllidaceae as a source of acetylcholinesterase inhibitory alkaloids

Andrade, Jean Paulo de; Giordani, Raquel Brandt; Torras-Claveria, Laura; Pigni, Natalia B.; Berkov, Strahil; Font-Bardı́a, Mercè; Calvet, Teresa; Konrath, Eduardo Luis; Bueno, Kelly Silveira da Silva; Sachett, Liana Guimarães; Dutilh, Julie Henriette Antoinette; Borges, Warley de Souza; Viladomat, Françesc; Henriques, Amélia T.; Nair, Jerald J.; Zuanazzi, José Ângelo Silveira; Bastida, Jaume

doi:10.1007/s11101-015-9411-7

Cited by 25 publications

(16 citation statements)

References 34 publications

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“…The purity of the alkaloid was checked by means of chromatographic (TLC, HPLC), and spectroscopic methods ( 1 H NMR). It was possible to confirm the identity of the product by comparison with galantamine data obtained in the literature (de Andrade et al, 2015).…”

Section: Methodsmentioning

confidence: 83%

Galantamine administration reduces reactive astrogliosis and upregulates the anti‐oxidant enzyme catalase in rats submitted to neonatal hypoxia ischemia

Odorcyk

Nicola

Durán‐Carabali

et al. 2017

Intl J of Devlp Neuroscience

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Neonatal hypoxia ischemia (HI) plays a role in the etiology of several neurological pathologies and causes severe sequelae. Acetylcholine is a neurotransmitter in the central nervous system and cholinesterase inhibitors have demonstrated a positive action over HI induced deficits. In order to evaluate the effects of pre and post-hypoxia administrations of galantamine, a cholinesterase inhibitor, in a model of perinatal HI, Wistar rats in the post-natal day 7 (PND7) were subjected to a combination of unilateral occlusion of the right carotid artery with the exposure to a 1h hypoxia. Intraperitoneal injections of galantamine were administered in two different protocols: one pre and other post-hypoxia. The analysis of brain structures volume at PND45 showed that pre-hypoxia galantamine treatment prevented tissue injury to the ipsilesional hippocampus. Also, immunofluorescence showed HI-induced increase in the number of astrocytes that was prevented by pre-hypoxia treatment. Biochemical analysis was performed in the ipsilesional hippocampus at PND8 and revealed that pre-hypoxia galantamine treatment: 1) prevented the neuronal loss induced by HI; 2) reduced the HI-induced hypertrophy of astrocytes; and 3) caused an increase in the activity of the anti-oxidant enzyme catalase. Overall, treatment with galantamine was able to prevent the brain damage, increase the survival of neurons, reduce astrocytic reaction and increase the activity of the anti-oxidant enzyme catalase in rats submitted to neonatal hypoxia ischemia.

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Section: Methodsmentioning

confidence: 83%

Galantamine administration reduces reactive astrogliosis and upregulates the anti‐oxidant enzyme catalase in rats submitted to neonatal hypoxia ischemia

Odorcyk

Nicola

Durán‐Carabali

et al. 2017

Intl J of Devlp Neuroscience

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“…Studies have suggested that there is an important role of GABAergic neurotransmission in stress, anxiety, and epilepsy. GABAergic neurotransmission dysfunction has been reported in the patients of anxiety which is associated with epilepsy 88 . It has been reported through experimental investigation that montanine protected against convulsions by modulating the neurotransmitter systems including GABA A receptors 44 .…”

Section: Montaninementioning

confidence: 99%

Role of Plant Derived Alkaloids and Their Mechanism in Neurodegenerative Disorders

et al. 2018

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Neurodegenerative diseases are conventionally demarcated as disorders with selective loss of neurons. Conventional as well as newer molecules have been tested but they offer just symptomatic advantages along with abundant side effects. The discovery of more compelling molecules that can halt the pathology of these diseases will be considered as a miracle of present time. Several synthetic compounds are available but they may cause several other health issues. Therefore, natural molecules from the plants and other sources are being discovered to replace available medicines. In conventional medicational therapies, several plants have been reported to bestow remedial effects. Phytochemicals from medicinal plants can provide a better and safer alternative to synthetic molecules. Many phytochemicals have been identified that cure the human body from a number of diseases. The present article reviews the potential efficacy of plant-derived alkaloids, which possess potential therapeutic effects against several NDDs including Alzheimer's disease (AD), Huntington disease (HD), Parkinson's disease (PD), Epilepsy, Schizophrenia, and stroke. Alkaloids include isoquinoline, indole, pyrroloindole, oxindole, piperidine, pyridine, aporphine, vinca, β-carboline, methylxanthene, lycopodium, and erythrine byproducts. Alkaloids constitute positive roles in ameliorating pathophysiology of these illnesses by functioning as muscarinic and adenosine receptors agonists, anti-oxidant, anti-amyloid and MAO inhibitors, acetylcholinestrase and butyrylcholinesterase inhibitor, inhibitor of α-synuclein aggregation, dopaminergic and nicotine agonist, and NMDA antagonist.

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“…vulgaris Bernh. 19 A broad spectrum of physiological and medicinal properties were attributed to the species of this family including the following: anti-inflammatory (Liu et al, 2015), acetylcholinesterase inhibitory, 20 immunostimulatory, and DNAbinding activities. Phytochemical analysis showed that the major components of F. vulgarisʼs volatile oil belong to sesqui-and mono-terpene groups of chemicals.…”

Section: Introductionmentioning

confidence: 99%

Manipulation of molecular pathways and senescence hallmarks by natural compounds in fibroblast cells

Momtaz

Baeeri

Rahimifard

et al. 2018

J of Cellular Biochemistry

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Aging contributes to an increased risk of developing a number of neurodegenerative and chronic disorders, predominantly related to oxidative stress (OS) and defects in the antioxidant balance. This study focused on the antisenescence effect of four plant species (Falcaria vulgaris, Ixiolirion tataricum, Ajuga chamaecistus, and Scabiosa flavida) on H2O2‐induced premature senescence in rat NIH3T3 fibroblasts, which were found to be rich in effective phytochemicals with traditional ethnobotanical backgrounds. Plant materials were collected, identified, and extracted. To determine the viability of NIH3T3 cells, an MTT assay was conducted. The levels of OS markers and the senescence‐associated ß‐galactosidase (SA‐ß‐GAL) activity were analyzed by the Elisa reader. The cell cycle pattern was evaluated by flow cytometry. The expression of senescence‐related inflammatory cytokines and the molecules involved in aging signaling pathways were investigated using the real‐time reverse transcription polymerase chain reaction (RT‐PCR). H2O2 treatment decreased cell viability and increased lipid peroxidation (LPO) and the reactive oxygen species (ROS) in NIH3T3s. However, S. flavida exhibited low cytotoxicity, reduced OS and SA‐ß‐GAL activities in NIH3T3 cells compared with the H2O2‐treated group. I. tataricum was the second best plant, although it was more toxic to NIHT3T cells. S. flavida decreased G0/G1 arrest and facilitated the G2/M transition of NIH3T3s, also downregulated the expression of p38, p53, p16, and the related inflammatory mediators. S. flavida potentially modulated senescence‐associated hallmarks in fibroblasts exposed to H2O2, thus it may inhibit the aging process via controlling the OS. Therefore it is a promising candidate for future antiaging explorations.

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The Brazilian Amaryllidaceae as a source of acetylcholinesterase inhibitory alkaloids

Cited by 25 publications

References 34 publications

Galantamine administration reduces reactive astrogliosis and upregulates the anti‐oxidant enzyme catalase in rats submitted to neonatal hypoxia ischemia

Galantamine administration reduces reactive astrogliosis and upregulates the anti‐oxidant enzyme catalase in rats submitted to neonatal hypoxia ischemia

Role of Plant Derived Alkaloids and Their Mechanism in Neurodegenerative Disorders

Manipulation of molecular pathways and senescence hallmarks by natural compounds in fibroblast cells

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