The brain renin‐angiotensin system plays a crucial role in regulating body weight in diet‐induced obesity in rats

Winkler, Martina; Schuchard, Johanna; Stölting, Ines; Vogt, Florian; Barkhausen, Jörg; Thorns, Christoph; Bäder, Michael; Raasch, Walter

doi:10.1111/bph.13461

Cited by 24 publications

(26 citation statements)

References 75 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In contrast to the effects observed in our studies, it was demonstrated that peripheral treatment with the AT 1 antagonist telmisartan prevented leptin resistance in rats fed a high-calorie/ cafeteria diet (27). Further, TGR(ASrAOGEN) rats, which exhibit glial-specific knockdown of angiotensinogen expression, are small and resistant to weight gain with high-calorie diets (28). It is unclear how species differences, peripheral actions of telmisartan, and developmental or receptor sensitivity changes in the TGR(ASrAOGEN) rats (29) may complicate the interpretation of these studies in concert with the current study.…”

Section: Discussioncontrasting

confidence: 99%

Angiotensin AT1A receptors on leptin receptor–expressing cells control resting metabolism

Claflin¹,

Sandgren²,

Lambertz³

et al. 2017

Journal of Clinical Investigation

View full text Add to dashboard Cite

Section: Discussioncontrasting

confidence: 99%

Angiotensin AT1A receptors on leptin receptor–expressing cells control resting metabolism

Claflin¹,

Sandgren²,

Lambertz³

et al. 2017

Journal of Clinical Investigation

View full text Add to dashboard Cite

“…Repeated RS was applied over 5 days (d) in accordance with the protocol of Dallman's group . In contrast to that study using lard and sucrose ), we used sweet-tasting chocolate and cookie bars here, which is more in line with our previous work concerning induced obesity, while controls only received chow diet (Miesel et al 2010, Schuchard et al 2015, Winkler et al 2016. As our previous findings showed that ARB treatment reduced both the intake of palatable food and HPA axis activity (Raasch et al 2006, Miesel et al 2012, we supposed that the HPA-RAS crosstalk functionally affects weight control.…”

Section: Introductionsupporting

confidence: 54%

“…One chow-and one CD-fed group of rats was treated with TEL (8 mg/kg bw , once per day by gavage, beginning at d8 until the end of the study). In our previous studies, 8 mg/kg TEL has been repeatedly shown to induce anti-obese efficacy in rats and mice (Muller-Fielitz et al 2011, Miesel et al 2012, Schuchard et al 2015, Winkler et al 2016. For drug administration, TEL was suspended in distilled water by using gum arabic (10% w/v) to achieve final concentrations.…”

Section: Protocolmentioning

confidence: 99%

Influence of AT1 blockers on obesity and stress-induced eating of cafeteria diet

Gustaityte

Winkler

Stoelting

et al. 2019

Journal of Endocrinology

Self Cite

View full text Add to dashboard Cite

Journal of Endocrinology240:1 65-79 V Gustaityte et al. ARB and stress eating of cafeteria diet AbstractBased on findings that treatment with AT 1 receptor blocker (ARB) prevents dietinduced obesity and that the activity of the hypothalamic-pituitary-adrenal (HPA) axis is stimulated by AngII and blocked by ARBs, we aimed to investigate whether ARB treatment can reduce stress-induced eating of cafeteria diet (CD), thus contributing to alterations in eating behavior. Sprague-Dawley rats were fed with chow or CD and treated with telmisartan (TEL, 8 mg/kg/day) or vehicle. At weeks 2 and 12, rats were stressed over five consecutive days by restraint stress (RS, 4 h) and by additional shaking at d5. Tail blood was sampled during RS to determine hormone levels. During the first period of RS, ACTH and corticosterone responses were diminished at d5 in CD-compared to chow-fed rats. Independently of feeding, TEL did not reduce stress hormones. Compared to food behavior before RS, the stress-induced CD eating increased in controls but remained unchanged in TEL-treated rats. After 12 weeks, TEL reduced weight gain and energy intake, particularly in CD-fed rats. Similar to the first RS period, corticosterone response was reduced in CD-fed rats at d5 during the second RS period. TEL did not further reduce stress hormones and did not lessen the CD eating upon RS. We conclude that CD feeding compensates for stress reactions. However, stress-induced CD eating was only reduced by TEL after short term, but not after longterm drug treatment. Thus, the potency of ARBs to lower HPA activity only plays a minor role in reducing energy intake to prevent obesity.

show abstract

“…DIO has been associated with an overexpression of angiotensin II, which regulates fluid balance and plays a role in regulating body weight. It has been hypothesized that CAP leads to weight loss by reducing angiotensin II levels . We observed the effectiveness of CAP in the initial weight analyses (Figure A).…”

Section: Discussionmentioning

confidence: 59%

Differential Effects of Diet and Weight on Taste Responses in Diet‐Induced Obese Mice

Ahart

Martin

Kemp

et al. 2019

Obesity

View full text Add to dashboard Cite

Original Article OBESITY BIOLOGY AND INTEGRATED PHYSIOLOGY Study ImportanceWhat is already known?► Obesity is often associated with impaired taste. ► The mechanisms associating obesity and taste are poorly understood. What does this study add?► Our study on diet-induced obese mice demonstrates that high-fat diet and excess weight can each contribute to impaired taste. ► There is selectivity in the effects of diet and weight that varies by stimulus.Objective: Previous studies have reported that individuals with obesity have reduced taste perception, but the relationship between obesity and taste is poorly understood. Earlier work has demonstrated that diet-induced obesity directly impairs taste. Currently, it is not clear whether these changes to taste are due to obesity or to the high-fat diet exposure. The goal of the current study was to determine whether diet or excess weight is responsible for the taste deficits induced by diet-induced obesity.Methods: C57BL/6 mice were placed on either high-fat or standard chow in the presence or absence of captopril. Mice on captopril did not gain weight when exposed to a high-fat diet. Changes in the responses to different taste stimuli were evaluated using live cell imaging, briefaccess licking, immunohistochemistry, and real-time polymerase chain reaction.Results: Diet and weight gain each affected taste responses, but their effects varied by stimulus. Two key signaling proteins, α-gustducin and phospholipase Cβ2, were significantly reduced in the mice on the highfat diet with and without weight gain, identifying a potential mechanism for the reduced taste responsiveness to some stimuli. Conclusions: Our data indicate that, for some stimuli, diet alone can cause taste deficits, even without the onset of obesity.Obesity (2020) 28, 284-292.

show abstract

The brain renin‐angiotensin system plays a crucial role in regulating body weight in diet‐induced obesity in rats

Cited by 24 publications

References 75 publications

Angiotensin AT1A receptors on leptin receptor–expressing cells control resting metabolism

Angiotensin AT1A receptors on leptin receptor–expressing cells control resting metabolism

Influence of AT1 blockers on obesity and stress-induced eating of cafeteria diet

Differential Effects of Diet and Weight on Taste Responses in Diet‐Induced Obese Mice

Contact Info

Product

Resources

About