The Brain Metabolic Correlates of the Main Indices of Neuropsychological Assessment in Alzheimer’s Disease

Chiaravalloti, Agostino; Ricci, Marcos Desídérío; Biagio, Daniele Di; Filippi, Luca; Martorana, Alessandro; Schillaci, Orazio

doi:10.3390/jpm10020025

Cited by 6 publications

(5 citation statements)

References 19 publications

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“…Position emission tomography (PET) with 2 [( 18)F]fluoro-2-deoxy-D-glucose (FDG-PET) provides visualisation of the metabolic rate of glucose in the brain (Hoffman et al, 2000;Phelps et al, 1979) which is a direct index of synaptic functioning and an indirect index of synaptic density (Attwell & Iadecola, 2002;Rocher et al, 2003;Sokoloff, 1977). Reduced (18F) FDG uptake correlates with cognition in AD and MCI (Chiaravalloti et al, 2020;Landau et al, 2011). Recently, a direct measure of synapse density has been developed by targeting proteins critical for synaptic functioning (Finnema et al, 2016(Finnema et al, , 2018.…”

Section: Beyond Csf Markersmentioning

confidence: 99%

Associations between cerebrospinal fluid markers and cognition in ageing and dementia: A systematic review

Saunders

Gadd

Spires‐Jones

et al. 2022

Eur J of Neuroscience

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Section: Beyond Csf Markersmentioning

confidence: 99%

Associations between cerebrospinal fluid markers and cognition in ageing and dementia: A systematic review

Saunders

Gadd

Spires‐Jones

et al. 2022

Eur J of Neuroscience

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“…This paralleled the reduced metabolic deficit observed in the posterior cingulate gyrus and parietal lobe, where damage is suggestive of AD pathology in patients with language deficits [ 44 , 48 ]. Moreover, 18 FDG uptake in the posterior cingulate-precuneus or in language-related Brodmann areas has been shown to correlate the main indices of RAVLT in patients with mild cognitive impairment (MCI) [ 51 ] and in AD [ 52 ]. These results are important because PE could stabilize hypometabolism or hypoperfusion in mild AD.…”

Section: Discussionmentioning

confidence: 99%

Neuroimaging analyses from a randomized, controlled study to evaluate plasma exchange with albumin replacement in mild-to-moderate Alzheimer’s disease: additional results from the AMBAR study

Cuberas-Borrós

Roca

Castell‐Conesa

et al. 2022

Eur J Nucl Med Mol Imaging

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Purpose This study was designed to detect structural and functional brain changes in Alzheimer’s disease (AD) patients treated with therapeutic plasma exchange (PE) with albumin replacement, as part of the recent AMBAR phase 2b/3 clinical trial. Methods Mild-to-moderate AD patients were randomized into four arms: three arms receiving PE with albumin (one with low-dose albumin, and two with low/high doses of albumin alternated with IVIG), and a placebo (sham PE) arm. All arms underwent 6 weeks of weekly conventional PE followed by 12 months of monthly low-volume PE. Magnetic resonance imaging (MRI) volumetric analyses and regional and statistical parametric mapping (SPM) analysis on 18F-fluorodeoxyglucose positron emission tomography (18FDG-PET) were performed. Results MRI analyses (n = 198 patients) of selected subcortical structures showed fewer volume changes from baseline to final visit in the high albumin + IVIG treatment group (p < 0.05 in 3 structures vs. 4 to 9 in other groups). The high albumin + IVIG group showed no statistically significant reduction of right hippocampus. SPM 18FDG-PET analyses (n = 213 patients) showed a worsening of metabolic activity in the specific areas affected in AD (posterior cingulate, precuneus, and parieto-temporal regions). The high-albumin + IVIG treatment group showed the greatest metabolic stability over the course of the study, i.e., the smallest percent decline in metabolism (MaskAD), and least progression of defect compared to placebo. Conclusions PE with albumin replacement was associated with fewer deleterious changes in subcortical structures and less metabolic decline compared to the typical of the progression of AD. This effect was more marked in the group treated with high albumin + IVIG. Trial registration (AMBAR trial registration: EudraCT#: 2011–001,598-25; ClinicalTrials.gov ID: NCT01561053).

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“…Raven's Non-Verbal Reasoning test (Raven et al, 2008) is commonly used when studying developmental disabilities and in neuropsychological assessments to characterize study populations and evaluate potential differences between study populations. In particular, the Raven's test has been used in ILT studies (Adi-Japha and Abu-Asba, 2014; Adi-Japha and Brestel, 2020) and in studies that assessed the RAVLT (e.g., Chiaravalloti et al, 2020). In the current study, the Raven was used to obtain a nonverbal assessment of intelligence, in a version suited for children aged 5-11.…”

Section: Non-verbal Reasoning -Raven's Educational Colored Progressive Matricesmentioning

confidence: 99%

Second Graders’ Grapho-Motor Skill Learning and Verbal Learning: The Effects of Socio-Educational Factors

Hollander

Adi-Japha

2021

Front. Psychol.

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Introduction: Children from low socioeconomic status (SES) families, and in particular, those with a lower level of maternal education, show lower fine-motor skills and lower vocabulary scores than their SES peers whose mothers have a higher level of education. Furthermore, low SES children frequently have difficulties in reading and spelling. These difficulties are attributed to deficits in the acquisition of skills through practice, such as those required for developing visual-motor routines, alongside deficits in the intentional acquisition of knowledge, such as those required in verbal learning. The aim of the current study was to test the effect of two background factors: low maternal education (ME) and risk of reading and spelling difficulties on practice-dependent learning of a motor task and intentional learning of a verbal task in second graders from low SES families.Methods: In 2016/17, 134 low-SES second graders with higher and lower ME (95 typical learners and 39 with reading and spelling difficulties) were assessed with (a) the Invented Letter Task (ILT; a grapho-motor skill learning task) across five time-points (initial- and end-training Day 1; initial- and end-training Day 2; and 2-weeks post-training), as well as an ILT transfer task; and (b) The Rey Auditory Verbal Learning Test (RAVLT; an intentional word-learning task in which a word list is read to children for five learning trials and is recalled 20 min later).Findings: Lower ME was associated with surplus segments in the performance of the motor task and its transfer to a novel condition as well as with lower recall on the verbal task, but not with the learning of both the motor and the verbal task. Having reading and spelling difficulties affected motor-task accuracy and also the way children learned the task, as evidenced by surplus segments at the beginning of Day 2, which were reduced with further practice.Conclusion: Low ME affected overall performance level. Reading and spelling difficulties resulted in atypical learning of the motor task. Future research on practice-dependent learning in the context of children coming from low SES families should focus on subgroups within this heterogeneous population.

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The Brain Metabolic Correlates of the Main Indices of Neuropsychological Assessment in Alzheimer’s Disease

Cited by 6 publications

References 19 publications

Associations between cerebrospinal fluid markers and cognition in ageing and dementia: A systematic review

Associations between cerebrospinal fluid markers and cognition in ageing and dementia: A systematic review

Neuroimaging analyses from a randomized, controlled study to evaluate plasma exchange with albumin replacement in mild-to-moderate Alzheimer’s disease: additional results from the AMBAR study

Second Graders’ Grapho-Motor Skill Learning and Verbal Learning: The Effects of Socio-Educational Factors

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