The brain insulin receptor gene network and associations with frailty index
Jannica S Selenius,
Patricia P Silveira,
Markus J Haapanen
et al.
Abstract:Objective
To investigate longitudinal associations between variations in the co-expression-based brain insulin receptor polygenic risk score and frailty, as well as change in frailty across follow-up.
Methods
This longitudinal study included 1605 participants from the Helsinki Birth Cohort Study. Biologically informed expression-based polygenic risk scores for the insulin receptor gene network, which measure genetic variation… Show more
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