The Brain Electrophysiological recording &amp; STimulation (BEST) toolbox

Hassan, Umair; Pillen, Steven; Zrenner, Christoph; Bergmann, Til Ole

doi:10.1016/j.brs.2021.11.017

Cited by 20 publications

(13 citation statements)

References 12 publications

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“…NIBS is essential in neurological disease rehabilitation, promoting neuroplasticity and modulating the excitability of brain structures ( 7 ). NIBS include transcranial magnetic stimulation (TMS) and transcranial electrical stimulation (TES) ( 8 ). As one of the non-invasive brain stimulation techniques, repetitive transcranial magnetic stimulation (rTMS) offers the opportunity to modulate cortical excitability and correct abnormal cortical activity after stroke, which has been recognized as a promising stroke rehabilitation method ( 9 , 10 ).…”

Section: Introductionmentioning

confidence: 99%

Intermittent theta-burst stimulation with physical exercise improves poststroke motor function: A systemic review and meta-analysis

et al. 2022

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BackgroundIntermittent theta-burst stimulation (iTBS) is an optimized rTMS modality that could modulate the excitability of neural structures. Several studies have been conducted to investigate the efficacy of iTBS in improving the motor function of stroke patients. However, the specific role of iTBS in motor function recovery after stroke is unclear. Hence, in our study, we performed a meta-analysis to investigate the efficacy of iTBS for the motor function improvement of stroke patients.MethodsMEDLINE, Embase, and Cochrane Library were searched until May 2022 for randomized controlled trials (RCTs).ResultsThirteen RCTs with 334 patients were finally included in our study. The primary endpoints were the Fugl-Meyer assessment scale (FMA) and Motor Assessment Scale (MAS) change from baseline. We found that iTBS led to a significant reduction in FMA score (P = 0.002) but not in MAS score (P = 0.24) compared with the sham group. Moreover, standard 600-pulse stimulation showed a better effect on motor function improvement than the sham group (P = 0.004), however, 1200-pulse iTBS showed no effect on motor function improvement after stroke (P = 0.23). The effect of iTBS for improving motor function only exists in chronic stroke patients (P = 0.02) but not in subacute patients (P = 0.27).ConclusionThis study supports that iTBS has good efficacy for improving motor function in stroke patients. Therefore, standard 600-pulse stimulation iTBS therapy is proper management and treatment for chronic stroke.

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Section: Introductionmentioning

confidence: 99%

Intermittent theta-burst stimulation with physical exercise improves poststroke motor function: A systemic review and meta-analysis

et al. 2022

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“…The ultrasound transducer was affixed to the center of the TMS coil using the same custom-made 3D-printed clamp as Experiments I & II ( Figure 12B ; DOI: 10.5281/zenodo.6517599 ). To administer stimulation at high temporal precision, both TUS and TMS were externally triggered via a bossdevice (sync2brain, Tübingen, Germany) using the BEST Toolbox (Hassan et al, 2022), where TMS was consistently applied 10 ms prior to the offset of ultrasound (i.e., following 390 ms of TUS). We tracked and maintained the position of TMS, and by extension TUS, using online neuronavigation in the same manner as described for Experiments I & II.…”

Section: Methodsmentioning

confidence: 99%

Auditory confounds can drive online effects of transcranial ultrasonic stimulation in humans

Kop

Oghli

Grippe

et al. 2023

Preprint

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Transcranial ultrasonic stimulation (TUS) is rapidly emerging as a promising non-invasive neuromodulation technique. TUS is already well-established in animal models, and now stimulation protocols that optimize neuromodulatory efficacy for human application are required. One promising protocol, pulsed at 1000 Hz, has consistently resulted in motor cortical inhibition. At the same time, a parallel research line has highlighted the potentially confounding influence of peripheral auditory stimulation arising from pulsing TUS at audible frequencies. Across four experiments, one preregistered, at three independent institutions, we employed tightly matched control conditions to disentangle direct neuromodulatory effects of TUS from those driven by the salient auditory confound in a combined transcranial ultrasonic and magnetic stimulation paradigm. We replicated motor cortical inhibition following TUS, but showed through both controls and manipulation of stimulation intensity, duration, and auditory masking conditions that this inhibition was driven by peripheral auditory stimulation rather than direct neuromodulation. This study highlights the substantial impact of the auditory confound, invites a reevaluation of prior findings, and calls for appropriate control conditions in future TUS work. Only when direct effects are disentangled from those driven by peripheral confounds can TUS fully realize its potential for neuroscientific research and clinical applications.

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“…For example, a brain-machine interface system that integrate frequency-domain near infrared spectroscopy (fdNIRS) input and tDCS output was designed to enable the application of closed loop tDCS ( Miao and Koomson, 2018 ). In addition, a recently developed tool box called brain electrophysiological recording and stimulation(BEST), had expanded the range of input recording and output stimulation devices with improved compatibility ( Hassan et al, 2022 ). These systems and algorithms would enable the real-time feedback control of input signals by providing a platform for input and output signal integrating and processing, providing technological pilar for future closed-loop studies.…”

Section: Closed Loop Transcranial Electrical Stimulationmentioning

confidence: 99%

Novel Non-invasive Transcranial Electrical Stimulation for Parkinson’s Disease

Yuan

et al. 2022

Front. Aging Neurosci.

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Conventional transcranial electrical stimulation (tES) is a non-invasive method to modulate brain activity and has been extensively used in the treatment of Parkinson’s disease (PD). Despite promising prospects, the efficacy of conventional tES in PD treatment is highly variable across different studies. Therefore, many have tried to optimize tES for an improved therapeutic efficacy by developing novel tES intervention strategies. Until now, these novel clinical interventions have not been discussed or reviewed in the context of PD therapy. In this review, we focused on the efficacy of these novel strategies in PD mitigation, classified them into three categories based on their distinct technical approach to circumvent conventional tES problems. The first category has novel stimulation modes to target different modulating mechanisms, expanding the rang of stimulation choices hence enabling the ability to modulate complex brain circuit or functional networks. The second category applies tES as a supplementary intervention for PD hence amplifies neurological or behavioral improvements. Lastly, the closed loop tES stimulation can provide self-adaptive individualized stimulation, which enables a more specialized intervention. In summary, these novel tES have validated potential in both alleviating PD symptoms and improving understanding of the pathophysiological mechanisms of PD. However, to assure wide clinical used of tES therapy for PD patients, further large-scale trials are required.

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The Brain Electrophysiological recording & STimulation (BEST) toolbox

Cited by 20 publications

References 12 publications

Intermittent theta-burst stimulation with physical exercise improves poststroke motor function: A systemic review and meta-analysis

Intermittent theta-burst stimulation with physical exercise improves poststroke motor function: A systemic review and meta-analysis

Auditory confounds can drive online effects of transcranial ultrasonic stimulation in humans

Novel Non-invasive Transcranial Electrical Stimulation for Parkinson’s Disease

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