The brain-derived neurotrophic factor is associated with alcohol dependence-related depression and antidepressant response

Su, Ning; Zhang, L.; Fei, F.; Hu, Hongzhen; Wang, K.; Han, Hongbin; Jiang, Xiong-Fei; Li, X.; Zhou, Han; Li, J.; Cao, Bo; Dang, Wei; Qu, Youge; Zhou, Fiona H.

doi:10.1016/j.brainres.2011.08.005

Cited by 38 publications

(35 citation statements)

References 59 publications

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“…Lower BDNF (and/or the BDNF Met allele) increases risk for depression symptoms in rhesus macaques exposed to early adversity , and in humans exposed to stress (Aguilera et al, 2009;Cirulli et al, 2011;Drachmann et al, 2009), with alcohol dependence (Su et al, 2011) or with Alzheimers disease .…”

Section: Discussionmentioning

confidence: 99%

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Brain-Derived Neurotrophic Factor Serum Levels and Genotype: Association with Depression during Interferon-α Treatment

Lotrich

Albusaysi

Ferrell

2012

Neuropsychopharmacol

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Depression has been associated with inflammation, and inflammation may both influence and interact with growth factors such as brainderived neurotrophic factor (BDNF). Both the functional Val66Met BDNF polymorphism (rs6265) and BDNF levels have been associated with depression. It is thus plausible that decreased BDNF could mediate and/or moderate cytokine-induced depression. We therefore prospectively employed the Beck Depression Inventory-II (BDI-II), the Hospital Anxiety and Depression Scale (HADS), and the Montgomery-Asberg Depression Rating Scale (MADRS) in 124 initially euthymic patients during treatment with interferon-alpha (IFN-a), assessing serum BDNF and rs6265. Using mixed-effect repeated measures, lower pretreatment BDNF was associated with higher depression symptoms during IFN-a treatment (F 144,17.2 ¼ 6.8; Po0.0001). However, although the Met allele was associated with lower BDNF levels (F 1,83.0 ¼ 5.0; P ¼ 0.03), it was only associated with increased MADRS scores (F 4,8.9 ¼ 20.3; Po0.001), and not the BDI-II or HADS. An exploratory comparison of individual BDI-II items indicated that the Met allele was associated with suicidal ideation, sadness, and worthlessness, but not neurovegetative symptoms. Conversely, the serotonin transporter promoter polymorphism (5-HTTLPR) short allele was associated with neurovegetative symptoms such as insomnia, poor appetite and fatigue, but not sadness, worthlessness, or suicidal ideation. IFN-a therapy further lowered BDNF serum levels (F 4,37.7 ¼ 5.0; P ¼ 0.003), but this decrease occurred regardless of depression development. The findings thus do not support the hypothesis that decreasing BDNF is the primary pathway by which IFN-a worsens depression. Nonetheless, the results support the hypothesis that BDNF levels influence resiliency against developing inflammatory cytokine-associated depression, and specifically to a subset of symptoms distinct from those influenced by 5-HTTLPR. Neuropsychopharmacology (2013) 38, 985-995;

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Section: Discussionmentioning

confidence: 99%

“…There may also be treatment implications. The BDNF Met allele could be associated with better response to SSRIs (Su et al, 2011;Taylor et al, 2011;Zhang et al, 2011), and suicidal ideation is the least common residual symptom following SSRI treatment (McClintock et al, 2011).…”

Section: Discussionmentioning

confidence: 99%

Brain-Derived Neurotrophic Factor Serum Levels and Genotype: Association with Depression during Interferon-α Treatment

Lotrich

Albusaysi

Ferrell

2012

Neuropsychopharmacol

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“…Meta-analyses evidenced either a higher response rate in Met patients that may be specific to Asian patients (Kato and Serretti, 2010;Yan et al, 2014; or no difference in response and remission rates between Met and Val/Val Caucasian patients (meta-analysis of Niitsu et al, 2013 including 10 studies (8 of Asian patients (Chi et al, 2010;Choi et al, 2006;Kang et al, 2010;Su et al, 2011;Tsai et al, 2003;Yoshida et al, 2007;Yoshimura et al, 2011;), one study of Caucasian patients (Wilkie et al, 2007) and data from STAR-D).…”

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confidence: 97%

Brain-derived neurotrophic factor Val66Met polymorphism and 6-month antidepressant remission in depressed Caucasian patients

Colle

Gressier

Verstuyft

et al. 2015

Journal of Affective Disorders

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“…The impact of this polymorphism has been widely studied in a variety of psychiatric diseases and drug addictions. Some studies conducted in the past have suggested a possible association of the rs6265 polymorphism with addiction to drugs, but the data have been inconsistent (Table 1) [11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30]. In order to more precisely evaluate the association between this polymorphism and the risk of drug dependence, a systematic review and meta-analysis of published case-control studies was conducted.…”

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confidence: 99%

BDNF rs6265 Polymorphism and Drug Addiction: a Systematic Review and Meta-Analysis

Haerian

2013

Pharmacogenomics

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A majority of studies have shown a link between the common functional rs6265 polymorphism of the BDNF gene and susceptibility to drug dependence. However, the pattern of results is inconsistent. To precisely evaluate this association, a systematic review and meta-analysis of previous case-control reports was conducted. Data from 20 studies containing 9419 participants (4665 cases and 4754 controls) conducted between 2004 and 2013 restricted to alcohol, nicotine, heroin, substance and methamphetamine dependency were meta-analyzed. Following quality control of the results, a significant association between C allele and methamphetamine dependence remained in south Asian subjects (p = 0.004). Similar results were detected in south Asian subjects for methamphetamine dependence and in Chinese subjects for heroin dependence under an autosomal codominant genotype model (TT vs CC, p = 0.005 and p = 0.0004, respectively). In conclusion, the rs6265 polymorphism may be a risk factor for methamphetamine dependence in south Asian subjects or for heroin dependence in Chinese subjects.

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The brain-derived neurotrophic factor is associated with alcohol dependence-related depression and antidepressant response

Cited by 38 publications

References 59 publications

Brain-Derived Neurotrophic Factor Serum Levels and Genotype: Association with Depression during Interferon-α Treatment

Brain-Derived Neurotrophic Factor Serum Levels and Genotype: Association with Depression during Interferon-α Treatment

Brain-derived neurotrophic factor Val66Met polymorphism and 6-month antidepressant remission in depressed Caucasian patients

BDNF rs6265 Polymorphism and Drug Addiction: a Systematic Review and Meta-Analysis

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