The bovine major histocompatibility complex (BoLA): Close linkage of the genes controlling serologically defined antigens and mixed lymphocyte reactivity

Usinger, William R.; Curie‐Cohen, Martin; Benforado, Kathy; Pringnitz, Deborah J.; Rowe, R B; Splitter, Gary A.; Stone, W. H.

doi:10.1007/bf00373322

Cited by 30 publications

(9 citation statements)

References 7 publications

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“…1982a,b). Histogenetic methods, such as the mixed lymphocyte reaction (MLR) (Usinger et al . 1981) and allospecific cytotoxic T lymphocyte (CTL) (Teale et al .…”

Section: Introductionmentioning

confidence: 99%

“…The serological approach in cattle led to the biochemical characterization of determinant-bearing molecules having the same properties as products of the human and mouse MHC (Hoang-Xuan et al 1982a,b). Histogenetic methods, such as the mixed lymphocyte reaction (MLR) (Usinger et al 1981) and allospecific cytotoxic T lymphocyte (CTL) (Teale et al 1985), were used to identify determinants that were eventually shown to be the property of MHC class I and class II antigens. The modern history of BoLA research began with the application of Southern blotting and restriction fragment length (RFLP) analysis.…”

Section: Introductionmentioning

confidence: 99%

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Structure, function and disease susceptibility of the bovine major histocompatibility complex

Takeshima¹,

Aida²

2006

Animal Science Journal

103

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The major histocompatibility complex (MHC) of cattle is known as the bovine leukocyte antigen (BoLA) and is located on chromosome 23. BoLA has been linked to variation in resistance to disease including bovine leukemia virus‐induced lymphoma and mastitis. Moreover, BoLA appears to influence other traits such as milk yield, growth and reproduction, which are not often measured in humans, and variations in individual immune response to antigen. The BoLA appears to be organized in a similar way to the MHC region in humans, but there are notable differences. A major rearrangement within the class II region has led to the division of the BoLA into two distinct subregions of chromosome 23 separated by about a third of the chromosome’s length. The class IIa subregion contains functionally expressed DR and DQ genes, while the class IIb subregion contains the genes of undefined status such as DYA, DYB, DMA, DMB, DOB, DOA, TAP1, TAP2, LAP2 and LMP7. In addition, one pair of human class II genes (DP) does not appear to have an equivalent in cattle, and there is one pair of DY genes that seem to be found only cattle, sheep and goats. In humans, three classical, polymorphic class I genes (HLA‐A, ‐B and ‐C ) are each present on all haplotypes. However, in cattle, none of the four (or more) classical class‐I genes identified are consistently expressed, and haplotypes differ from one to another in both the gene number and composition. These variations in both class I and II are likely to play an important role in cattle immune responses. This review summarizes current knowledge of the structural and functional features and disease association of BoLA genes.

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“…1982a,b). Histogenetic methods, such as the mixed lymphocyte reaction (MLR) (Usinger et al . 1981) and allospecific cytotoxic T lymphocyte (CTL) (Teale et al .…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Structure, function and disease susceptibility of the bovine major histocompatibility complex

Takeshima¹,

Aida²

2006

Animal Science Journal

103

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“…One class I locus, designated BOLA-A, has been defined serologically (Amorena & Stone 1978;Spooner etal. 1978;Caldwell1979), while a class I1 locus, designated BOLA-D, has been established by studies on the genetic control of mixed lymphocyte reactions [Usinger et al 1977). Close linkage between BOLA-A and BOLA-D has been reported (Spooner et al 1978;Usinger et al 1981) A major impetus for research on the BoLA system of cattle is the possibility of finding relationships between MHC polymorphism and disease in this economically important species.…”

Section: Introductionmentioning

confidence: 99%

Genomic hybridization of bovine class II major histocompatibility genes: 2. Polymorphism of DR genes and linkage disequilibrium in the DQ‐DR region

et al. 1986

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Class I1 genes of the bovine major histocompatibility complex have been investigated by Southern blot analysis using human cDNA probes for DQa, DQP, D R a and DRP. In this report restriction fragment length polymorphisms of D R a and DRP are described. The polymorphisms were interpreted genetically by analysing five paternal half-sib families of the Swedish Red and White Breed, comprising altogether 28 offspring. Using the restriction enzymes BamHI, EcoRI and PvuII, three DRa and three DRP allelic fragment patterns were resolved. The D R a and DRP genes thus appear to be much less polymorphic than the previously described D Q a and DQP genes. Also, the observed linkage disequilibrium between D R genes was less pronounced than that between D Q genes, whereas the association between D R and D Q haplotypes was very strong. The family data available indicated strongly that the DQa, DQP, D R a and DRP genes are all closely linked.

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“…J.Immunol. Evidence for linkage has also been provided by Usinger et al[25] using MLR studies in full-sib families, and Anderson et al[8] using RFLP analysis. This fi chain was not present in precipitates that were surface-labeled, suggesting either that it did not label well or was not expressed on the surface of the cell.…”

mentioning

confidence: 89%

Isoelectric Focusing of Bovine Major Histocompatibility Complex Class I Molecules

Watkins

Shadduck

Stone

et al. 1989

Int J Immunogenetics

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Serological approaches have been relatively unsuccessful in defining the allelic products of the bovine major histocompatibility (MHC) class I1 loci. We demonstrate that bovine class I1 allelic products can be characterized by precipitation with a polyclonal antiserum and separation using one-dimensional isoelectric focusing. Polymorphic fi chains were present in immunoprecipitates from both biosynthetically and surfacelabeled lectin-stimulated bovine T cells. Precipitates from biosynthetically labeled but not surface-labeled T cells contained a basic invariant chain and a non-polymorphic structure. The non-polymorphic structure appears to be a fi chain. The polymorphic class I1 fi chain co-segregated with bovine MHC class I allelic products in a halfsibling family, providing evidence for linkage between bovine class I and class I1 loci. This approach to the biochemical analysis of the bovine class I1 structures should facilitate the investigation of the association between the bovine products and disease susceptibility.

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The bovine major histocompatibility complex (BoLA): Close linkage of the genes controlling serologically defined antigens and mixed lymphocyte reactivity

Cited by 30 publications

References 7 publications

Structure, function and disease susceptibility of the bovine major histocompatibility complex

Structure, function and disease susceptibility of the bovine major histocompatibility complex

Genomic hybridization of bovine class II major histocompatibility genes: 2. Polymorphism of DR genes and linkage disequilibrium in the DQ‐DR region

Isoelectric Focusing of Bovine Major Histocompatibility Complex Class I Molecules

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