The bone morphogenetic protein system and the regulation of ovarian follicle development in mammals

Rossi, R.O.D.S.; Costa, Jonathan L.; Silva, Anderson Weiny Barbalho; Saraiva, M.V.A.; Hurk, R. van den; Silva, José R.V.

doi:10.1017/s096719941400077x

Cited by 34 publications

(19 citation statements)

References 139 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Among BMP proteins, BMP4 and BMP-7 are reported to be of stromal cell and/or pre-thecal origin [27–32]. BMP4 and its receptors BMPR-IB and BMPR-II (and BMPR-IA, weakly) have been detected in mouse ovaries [27, 28, 30–32]. Our data indicate that SENP1 deficiency in SM22 + mouse stromal cells, effectively reduces BMP4 mRNA and protein expression in ovary.…”

Section: Discussionmentioning

confidence: 66%

Stromal Senp1 promotes mouse early folliculogenesis by regulating BMP4 expression

et al. 2017

View full text Add to dashboard Cite

BackgroundMammalian folliculogenesis, maturation of the ovarian follicles, require both growth factors derived from oocyte and surrounding cells, including stromal cells. However, the mechanism by which stromal cells and derived factors regulate oocyte development remains unclear.ResultsWe observed that SENP1, a small ubiquitin-related modifier (SUMO)-specific isopeptidase, was expressed in sm22α-positive stromal cells of mouse ovary. The sm22α-positive stromal cells tightly associated with follicle maturation. By using the sm22α-specific Cre system, we show that mice with a stromal cell-specific deletion of SENP1 exhibit attenuated stroma-follicle association, delayed oocyte growth and follicle maturation with reduced follicle number and size at early oocyte development, leading to premature ovarian failure at late stages of ovulating life. Mechanistic studies suggest that stromal SENP1 deficiency induces down-regulation of BMP4 in stromal cells concomitant with decreased expression of BMP4 receptor BMPR1b and BMPR2 on oocytes.ConclusionsOur data support that protein SUMOylation-regulating enzyme SENP1 plays a critical role in early ovarian follicle development by regulating gene expression of BMP4 in stroma and stroma-oocyte communication.Electronic supplementary materialThe online version of this article (doi:10.1186/s13578-017-0163-5) contains supplementary material, which is available to authorized users.

show abstract

Section: Discussionmentioning

confidence: 66%

Stromal Senp1 promotes mouse early folliculogenesis by regulating BMP4 expression

et al. 2017

View full text Add to dashboard Cite

show abstract

“…With over 20 members, BMPs/GDFs constitute the largest subfamily of the TGF-β superfamily and were initially identified as osteoinductive cytokines that may promote bone and cartilage formation (Wang et al ., 1988; Wagner et al ., 2010). Several publications have documented that locally produced BMPs are implicated in the formation and function of mammalian germ cells and that they participate in the regulation of ovarian functions (Yi et al ., 2001; Shimasaki et al ., 2004; Khan et al ., 2016; Rossi et al ., 2016). Moreover, naturally occurring gene mutations of BMP ligands and dysregulated BMP signaling are associated with prominent pathologies of human reproduction (Persani et al ., 2014; Qin et al ., 2015).…”

Section: Introductionmentioning

confidence: 99%

Oocyte–somatic cell interactions in the human ovary—novel role of bone morphogenetic proteins and growth differentiation factors

Chang

Qiao

Leung

2016

Hum. Reprod. Update

222

207

View full text Add to dashboard Cite

BACKGROUNDInitially identified for their capability to induce heterotopic bone formation, bone morphogenetic proteins (BMPs) are multifunctional growth factors that belong to the transforming growth factor β superfamily. Using cellular and molecular genetic approaches, recent studies have implicated intra-ovarian BMPs as potent regulators of ovarian follicular function. The bi-directional communication of oocytes and the surrounding somatic cells is mandatory for normal follicle development and oocyte maturation. This review summarizes the current knowledge on the physiological role and molecular determinants of these ovarian regulatory factors within the human germline-somatic regulatory loop.OBJECTIVE AND RATIONALEThe regulation of ovarian function remains poorly characterized in humans because, while the fundamental process of follicular development and oocyte maturation is highly similar across species, most information on the regulation of ovarian function is obtained from studies using rodent models. Thus, this review focuses on the studies that used human biological materials to gain knowledge about human ovarian biology and disorders and to develop strategies for preventing, diagnosing and treating these abnormalities.SEARCH METHODSRelevant English-language publications describing the roles of BMPs or growth differentiation factors (GDFs) in human ovarian biology and phenotypes were comprehensively searched using PubMed and the Google Scholar database. The publications included those published since the initial identification of BMPs in the mammalian ovary in 1999 through July 2016.OUTCOMESStudies using human biological materials have revealed the expression of BMPs, GDFs and their putative receptors as well as their molecular signaling in the fundamental cells (oocyte, cumulus/granulosa cells (GCs) and theca/stroma cells) of the ovarian follicles throughout follicle development. With the availability of recombinant human BMPs/GDFs and the development of immortalized human cell lines, functional studies have demonstrated the physiological role of intra-ovarian BMPs/GDFs in all aspects of ovarian functions, from follicle development to steroidogenesis, cell–cell communication, oocyte maturation, ovulation and luteal function. Furthermore, there is crosstalk between these potent ovarian regulators and the endocrine signaling system. Dysregulation or naturally occurring mutations within the BMP system may lead to several female reproductive diseases. The latest development of recombinant BMPs, synthetic BMP inhibitors, gene therapy and tools for BMP-ligand sequestration has made the BMP pathway a potential therapeutic target in certain human fertility disorders; however, further clinical trials are needed. Recent studies have indicated that GDF8 is an intra-ovarian factor that may play a novel role in regulating ovarian functions in the human ovary.WIDER IMPLICATIONSIntra-ovarian BMPs/GDFs are critical regulators of folliculogenesis and human ovarian functions. Any dysregulation or variations in these ligand...

show abstract

“…The function and mechanism of BMPs in reproduction have gradually been revealed in recent years Rossi et al, 2016). For instance, in bovine granulosa cells, BMP4 and BMP7 enhanced cell number and the secretion of basal and IGF-stimulated oestradiol, inhibin A, activin A and follistatin, while they suppressed the progesterone secretion (Glister et al, 2004).…”

Section: Introductionmentioning

confidence: 99%

A bone morphogenetic protein ligand and receptors in mud crab: A potential role in the ovarian development

Shu

Yang

Huang

et al. 2016

Molecular and Cellular Endocrinology

View full text Add to dashboard Cite

The bone morphogenetic protein system and the regulation of ovarian follicle development in mammals

Cited by 34 publications

References 139 publications

Stromal Senp1 promotes mouse early folliculogenesis by regulating BMP4 expression

Stromal Senp1 promotes mouse early folliculogenesis by regulating BMP4 expression

Oocyte–somatic cell interactions in the human ovary—novel role of bone morphogenetic proteins and growth differentiation factors

A bone morphogenetic protein ligand and receptors in mud crab: A potential role in the ovarian development

Contact Info

Product

Resources

About