The Bone Morphogenesis Protein-2 (BMP-2) is Associated with Progression to Metastatic Disease in Gastric Cancer

Abstract

Purpose: Bone Morphogenetic Proteins (BMPs) are members of the TGF-β superfamily and it has been demonstrated that BMPs enhance migration, invasion and metastasis. The purpose of this study was to identify the association between the serum BMP-2 level and the progression status of gastric cancer.Materials and Methods: Fifty-five patients with metastatic gastric cancer (metastatic disease group), six patients with early gastric cancer without lymph node metastasis (the EGC group), and ten healthy control subjects were enrolled in this study. The serum BMP-2 level was quantified by use of a commercially available ELISA kit. In EGC group patients and patients with metastatic disease, whole blood was obtained before endoscopic mucosal resection and before the commencement of a scheduled cycle of systemic chemotherapy, respectively.Results: No significant difference in the mean serum BM P -2 le ve ls wa s obse rve d be twe e n the control subjects and the EGC group patients (87.95 pg/ml for the control subjects and 84.50 pg/ml for the EG C group, p=1.0). However, the metastatic disease group patients had a significantly higher level of serum BMP (179.61 pg/ml) than the control subjects and EGC group patients (87.95 pg/ml for the control subjects and 84.50 pg/ml for the EGC group, p＜0.0001). Moreover, the mean serum BMP-2 level from patients with a bone metastasis was significantly higher than the mean serum BMP-2 level from patients without a bone metastasis (

Serum BMP-2 Up-regulation as an Indicator of Poor Survival in Advanced Non-small Cell Lung Cancer Patients

“…The prognostic impact of BMP-2 levels in cancer patients has been evaluated in some studies (Park et al, 2008;Ma et al, 2010). Using immunohistochemical analysis, Ma et al evaluated the influence of intratumoral BMP-2 on five-year survival in 100 patients with epithelial ovarian cancer, showing that the median five-year survival was significantly longer in the groups with a low intratumoral BMP-2 staining intensity (40.32%) than that in the group with tumors expressing high levels of BMP-2 (18.42%, P=0.023) .…”

Downregulation of hemojuvelin prevents inhibitory effects of bone morphogenetic proteins on iron metabolism in hepatocellular carcinoma

“…6,[8][9][10] It is furthermore known that BMPs not only have an important role in the iron sensing pathway but are also involved in the development and progression of different kinds of cancer. [11][12][13] We recently demonstrated that BMP4 promotes the progression of hepatocellular carcinoma (HCC).14 Noteworthy, up to now the impact of enhanced BMP expression on (changes in) iron metabolism in HCC, one of the most common cancers worldwide, 15 has not been addressed. Thus, one may hypothesize that patients with enhanced BMP expression levels develop anemia through increased levels of hepcidin, which is responsible for internalization and degradation of ferroportin to limit intestinal iron uptake.…”

“…6,[8][9][10] It is furthermore known that BMPs not only have an important role in the iron sensing pathway but are also involved in the development and progression of different kinds of cancer. [11][12][13] We recently demonstrated that BMP4 promotes the progression of hepatocellular carcinoma (HCC).…”

Coding polymorphisms of bone morphogenetic protein 2 contribute to the development of childhood IgA nephropathy

“…clinically, Bmp2 has been used for various therapeutic interventions, such as bone defects, non-union fracture, spinal fusion, osteoporosis and root canal surgery (3). apart from bone disease, Bmp2 has been shown to be associated with invasion and metastasis of several tumor cell lines (15,19,20) and is used as a prognostic marker for specific tumors (21). Moreover, it is involved in vascular physiology as a proatherogenic mediator in the arterial wall (4).…”