The bone marrow microenvironment—driver of leukemia evolution?

García, Mayra; Chen, Ching-Cheng

doi:10.21037/sci.2017.02.03

Cited by 5 publications

(4 citation statements)

References 18 publications

(28 reference statements)

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“…Together, we suggest that the anti‐apoptotic effects of Cyr61 are derived from the activation of NF‐κB signaling and the transactivation of Bcl‐2. Considering the complexity of the BM microenvironment with a variety of cytokines, chemokines, and other growth factors, in vitro studies seem to be insufficient to elucidate the role that Cyr61 plays in inhibiting the apoptosis of CML cells induced by IM treatment. Therefore, further in vivo studies are required to identify the signaling pathways underlying the ability of Cyr61 to decrease IM‐induced CML cell apoptosis.…”

Section: Discussionmentioning

confidence: 99%

“…The chemoprotective effect of the BM microenvironment has been shown using in vitro CML cellular models under IM treatment . For example, cytokines within the BM microenvironment, such as interleukin (IL)‐3, IL‐7, granulocyte‐macrophage colony‐stimulating factor, and C‐X‐C motif chemokine 12, can protect CML cells from IM‐induced apoptosis and promote CML cell survival . However, it remains unknown whether there are other soluble factors that are chemoprotective for CML cells under IM treatment.…”

Section: Introductionmentioning

confidence: 99%

“…Recently, attention has been drawn to the BM microenvironment, which plays an important role in the differentiation, migration, proliferation, survival, and drug resistance of leukemia cells . The chemoprotective effect of the BM microenvironment has been shown using in vitro CML cellular models under IM treatment . For example, cytokines within the BM microenvironment, such as interleukin (IL)‐3, IL‐7, granulocyte‐macrophage colony‐stimulating factor, and C‐X‐C motif chemokine 12, can protect CML cells from IM‐induced apoptosis and promote CML cell survival .…”

Section: Introductionmentioning

confidence: 99%

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Cysteine‐rich protein 61 regulates the chemosensitivity of chronic myeloid leukemia to imatinib mesylate through the nuclear factor kappa B/Bcl‐2 pathway

Song

Cai

et al. 2019

Cancer Science

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Although the targeted tyrosine kinase inhibitor imatinib mesylate (IM) has achieved significant responses against CML in the clinical setting, a small proportion of patients fail to respond to IM treatment and their disease continues to progress, indicating resistance to IM therapy. As a secreted extracellular matrix protein, cysteine‐rich protein 61 (Cyr61) plays an important role in the resistance of solid tumors to chemotherapy, but its role in CML is unclear. In the present study, we observed that Cyr61 levels were upregulated in the plasma and bone marrow (BM) of patients with CML as well as in K562 cells. This upregulation of Cyr61 significantly decreased IM‐induced cellular apoptosis of K562 cells through nuclear factor kappa B/B‐cell lymphoma 2 pathways. Inhibition of Cyr61 restored the chemosensitivity of K562 cells to IM both in vitro and in vivo. Thus, our results showed for the first time that Cyr61 plays an important role in regulating the chemosensitivity of CML cells to IM, suggesting that selectively targeting Cyr61 directly or its relevant effector pathways may provide potential value in improving the clinical response of patients with CML to IM treatment.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Cysteine‐rich protein 61 regulates the chemosensitivity of chronic myeloid leukemia to imatinib mesylate through the nuclear factor kappa B/Bcl‐2 pathway

Song

Cai

et al. 2019

Cancer Science

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“…Відомо, що строма кісткового мозку впливає на гемопоез і координує взаємодію з клітинами-попередниками [8,9,10]. Зокрема, стромальні фібробласти формують гемопоетичне мікрооточення і можуть відігравати як захисну роль, так і бути промоторами пухлинного процесу [11]. Ми показали, що висока проліферативна активність КУОф вища за 70,0 та нижча за 11,0 на 10 5 ядровміcних клітин співпадала з більш короткою виживаністю хворих.…”

Section: таблиця 6 -unclassified