The Bone Marrow in Hyperthyroidism and Hypothyroidism

Axelrod, Arnold R.; Berman, Laurence

doi:10.1182/blood.v6.5.436.436

Cited by 74 publications

(26 citation statements)

References 40 publications

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“…Increased rates of cell proliferation and heightened anabolic activity have been demonstrated in relatively few other tissues in thyroid disease. The bone marrow was shown by Axelrod & Berman (1951) to become hypercellular in thyrotoxicosis with hyperplasia of the myeloid series whereas in hypothyroidism the reverse effect occurred (Axelrod & Berman, 1951;Tudhope & Wilson, i960). A further example is the decreased replication in duodenal mucosa of rats following thyroidectomy (Leblond & Carriere, 1955).…”

Section: Discussionmentioning

confidence: 99%

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The epidermis in thyroid disease*

1976

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Epidermal dimensions, replication and anabolic activity have been studied in thirteen patients with thyrotoxicosis and seven patients with hypothyroidism. Epidermal thickness and rete pattern were significantly reduced in hypothyroidism. The rates of epidermal cell division and anabolic activity in the epidermis were estimated by measuring the rates of incorporation of tritiated precursor compounds and were found to be increased in thyrotoxicosis. The mean autoradiographic labelling indices after the intracutaneous injection of tritiated thymidine were 9-1% in thyrotoxic patients and 4-3% in the hypothyroid group. None of the changes observed could be correlated accurately with the degree of thyroid gland activity, but increased thyroid activity was reflected in the epidermal changes better than decreased thyroid activity.

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Section: Discussionmentioning

confidence: 99%

“…In thyrotoxicosis the skin feels warm and smooth and there is often increased sweating and pigmentation. In hypothyroidism the hair becomes coarse and the dermis thickens (Black, Bottoms & Shuster, 1972). In addition, the skin is dry and sometimes scaly, changes which seem to be essentially epidermal in origin.…”

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confidence: 99%

The epidermis in thyroid disease*

1976

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“…An association between thrombocytopenia and hyperthyroidism has been observed [reviewed in reference 31, but the etiology and pathogenesis of the thrombocytopenia have not been established. A shortened platelet survival time [4,5] and an increase in megakaryocytes in bone marrow [6] have been reported in hyperthyroid subjects even when platelet counts were normal. The aim of the present study was to investigate the possibility that other platelet abnormalities were present in hyperthyroid patients with normal platelet counts.…”

Section: Introductionmentioning

confidence: 90%

Mean platelet volume is increased in hyperthyroidism

et al. 1988

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In 28 unselected patients with hyperthyroidism, platelet count, platelet hematocrit, mean platelet volume, and platelet distribution width were measured at the time of presentation and again when the patients were euthyroid. On return to the euthyroid state, there were highly significant falls in the mean values of the mean platelet volume (16% decline, P less than 0.001) and the platelet hematocrit (16% decline, P less than 0.001) and a slight but highly significant increase in the mean value of the platelet distribution width (2% increase, P less than 0.01). A decline in mean platelet volume was observed in 24 of 28 patients (86%); three patients showed no change. There was no significant change in the mean value of the platelet count. The observed effects of thyrotoxicosis on platelets appeared to be largely independent of the well-known effects on erythrocytes and white blood cells. An increase in mean platelet volume is a regular feature of hyperthyroidism that has not previously been described.

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“…Treated maternal hypothyroidism is not associated with adverse perinatal outcome. 10 This study conducted to evaluate the severity and type of anemia in hypothyroid pregnant women.…”

Section: Introductionmentioning

confidence: 99%

Study of anemia in hypothyroid pregnant patients

Singh

Mani

Yadav

et al. 2020

Int J Reprod Contracept Obstet Gynecol

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Background: Hypothyroidism and anemia in pregnancy causes significantly high maternal and fetal morbidity and mortality. Aim of this study was to determine the prevalence of anemia, grade and type of anemia in hypothyroid pregnant patients. Methods: This prospective study was conducted at department of obstetrics and gynecology, CSSH, Meerut, Uttar Pradesh over a period of 2 years from August 2017 to August 2019. Patients who attended the OPD during the study period were included in the study according the inclusion criteria and were studied for the clinical profile, obstetric history and detailed examination. Investigations were done including hemoglobin, blood grouping, urine routine, HbsAg, Anti-HCV, HIV, RBS and serum TSH. The women with raised serum TSH, indicating hypothyroidism, test for free T3, free T4 and anti-TPO was done, and the hypothyroid females with anemia were further investigated with GBP for the type of anemia, data evaluated with adequate statistical analysis. Results: A total 223 patients, enrolled in the study, prevalence of anemia in hypothyroid patients was 69.95%. Most patients with overt hypothyroidism had mild anemia 26 (68.4%), while in sub-clinical hypothyroid patients' group most of the patients had moderate anemia. In the overt hypothyroid and subclinical hypothyroid group dimorphic anemia was the most prevalent form of anemia with 52.6% and 74.6% respectively. Conclusions: Prevalence of anemia in hypothyroid pregnant patients is 69.95%. Dimorphic anemia is most prevalent; hence it is important to study anemia in antenatal patients with hypothyroidism and appropriate strategies should be used to prevent and treat anemia.

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The Bone Marrow in Hyperthyroidism and Hypothyroidism

Cited by 74 publications

References 40 publications

The epidermis in thyroid disease*

The epidermis in thyroid disease*

Mean platelet volume is increased in hyperthyroidism

Study of anemia in hypothyroid pregnant patients

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