The body as a living bioreactor: a feasibility study of pedicle flaps for tracheal transplantation

Jana, Tanima; Khabbaz, Eyad; Bush, Carrie M.; Prosser, J. Drew; Birchall, Martin A.; Nichols, Carol; Postma, Gregory N.; Weinberger, Paul M.

doi:10.1007/s00405-012-2105-5

Cited by 13 publications

(11 citation statements)

References 20 publications

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“…Whereas the present data are preliminary, it is proposed that some form of graft recellularization may be the best option before anastomosing the graft to serve as a replacement airway. This recellularization of the graft could occur using an ex‐vivo bioreactor in the peritoneum or omentum—as reported initially by the London group 1 —or by using a local transpositional muscle flap as an in vivo bioreactor . Additionally, a short‐term stent could be potentially used to help support the airway lumen during recellularization and engraftment, as previously proposed .…”

Section: Discussionmentioning

confidence: 93%

See 1 more Smart Citation

Biomechanical changes from long‐term freezer storage and cellular reduction of tracheal scaffoldings

Jones¹,

Cunningham²,

Faircloth³

et al. 2014

The Laryngoscope

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Section: Discussionmentioning

confidence: 93%

“…More recently, it has been proposed to bypass the bioreactor step and implant the graft directly . Several groups have hypothesized that it may be possible to use the body as a living bioreactor, allowing graft recellularization in vivo . It is possible that attempts to bypass the external bioreactor may be problematic, however .…”

Section: Discussionmentioning

confidence: 99%

Biomechanical changes from long‐term freezer storage and cellular reduction of tracheal scaffoldings

Jones¹,

Cunningham²,

Faircloth³

et al. 2014

The Laryngoscope

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“…Rejection seemed to be avoided[31,67]. This preceded a plethora of animal studies, particularly transplantation studies, and in the last few years, attempts to translate this to patients[40,41,43,44,49,50,54,56,61]. Recently, research has focused on tracheal stem cell regeneration.…”

Section: S Onwardsmentioning

confidence: 99%

“…Despite initial positive results, the outcomes have been generally poor and as such should be used with caution[42]. Pedicled flaps may serve to implant and maintain the stem cell generated trachea prior to reconstruction[41]. A recent pilot study has used three-dimensional printing of an artificial tracheal graft[40].…”

Section: S Onwardsmentioning

confidence: 99%

Prosthetic reconstruction of the trachea: A historical perspective

Virk

Zhang

Nouraei

et al. 2017

WJCC

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This review discusses the history of tracheal reconstruction; from early work to future challenges. The focus is primarily on prosthetic tracheal reconstruction in the form of intraluminal stents, patch repairs, circumferential repairs and replacement of the trachea. A historical perspective of materials used such as foreign materials, autografts, allografts, xenografts and techniques, along with their advantages and disadvantages, is provided.

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“…59,60 Omental flaps longer than 4 cm frequently resulted in ischemic tracheal segments and stenosis. 96 Preliminary implantation into a vascularized tissue or flap with delayed transfer into the defect has proven to be more successful.…”

Section: Tracheal Transplantationmentioning

confidence: 99%

Advances in Tracheal Reconstruction

Haykal¹,

Salna

Waddell

et al. 2014

Plastic and Reconstructive Surgery Global Open

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Summary:A recent revival of global interest for reconstruction of long-segment tracheal defects, which represents one of the most interesting and complex problems in head and neck and thoracic reconstructive surgery, has been witnessed. The trachea functions as a conduit for air, and its subunits including the epithelial layer, hyaline cartilage, and segmental blood supply make it particularly challenging to reconstruct. A myriad of attempts at replacing the trachea have been described. These along with the anatomy, indications, and approaches including microsurgical tracheal reconstruction will be reviewed. Novel techniques such as tissue-engineering approaches will also be discussed. Multiple attempts at replacing the trachea with synthetic scaffolds have been met with failure. The main lesson learned from such failures is that the trachea must not be treated as a “simple tube.” Understanding the anatomy, developmental biology, physiology, and diseases affecting the trachea are required for solving this problem.

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The body as a living bioreactor: a feasibility study of pedicle flaps for tracheal transplantation

Cited by 13 publications

References 20 publications

Biomechanical changes from long‐term freezer storage and cellular reduction of tracheal scaffoldings

Biomechanical changes from long‐term freezer storage and cellular reduction of tracheal scaffoldings

Prosthetic reconstruction of the trachea: A historical perspective

Advances in Tracheal Reconstruction

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