The BLOODSAFE program: Building the future of access to safe blood in Sub‐Saharan Africa

Delaney, Meghan; Telke, Susan; Zou, Shimian; Williams, Makeda; Aridi, Jackline O.; Rudd, Kristina E.; Puyana, Juan Carlos; Kumar, Pratap; Appiah, Bernard; Dei‐Adomakoh, Yvonne; Asamoah‐Akuoko, Lucy; Olayemi, Edeghonghon; Singogo, Emmanuel; Hosseinipour, Mina C.; M’baya, Bridon; Chipeta, Effie; Reilly, Cavan; Kamu, Robert; Munoz‐Valencia, Alejandro; Raykar, Nakul; Barnes, Linda; Makin, Jennifer; Bidanda, Bopaya; Yazer, Mark H.; Macleod, Jana; Muiri, Carolyne Nkoki; Olayo, Bernard; Murithi, Gatwiri; Rajgopal, Jayant; Tian, Yi-Qi; Zeng, Bo; Kivuli, Tecla; Mate, Muthoni; Musa, Abdirahaman; Mical, Cindy; Nyagol, Hellen; Ochieng, Kevin; Epuu, Tonny; Kuma, Amma Benneh‐Akwasi; Segbefia, Catherine; Yawson, Alfred E.; Adu‐Afarwuah, Seth; Adongo, Philip Baba; Acquah, Michael; Tancred, Tara; Dei, Emmanuel Nene; Bates, Imelda; Ofori‐Acquah, Solomon; Ansah, Justina; John‐Teye, Dilys; Cohn, Claudia S.; Chu, Haitao; Burns, Adam; Croal, Mitch; Eckroth, Kate; Ryn, Collin Van; Chiwindo, Titus; Mwapasa, Victor; Muula, Adamson S; Mhango, Patani; Kayira, Princess; Likaka, Andrew; Dzama, Wilfred; Nsamala, Natasha; Kadewere, Geoffrey; Joshua, Martias

doi:10.1111/trf.17091

Cited by 4 publications

(4 citation statements)

References 22 publications

(35 reference statements)

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“…These challenges also extend to the perioperative period, where infants and toddlers may have an increased risk of adverse advents if appropriate anesthesia support is unavailable. Additionally, blood availability in our setting often does not meet patient care demands [20, 21]. Thus, hemorrhage and hypothermia may increase the chance of mortality in the early excision period, especially in younger children.…”

Section: Discussionmentioning

confidence: 99%

The Timing of Operative Intervention for Pediatric Burn Patients in Malawi

Davis,

An,

Kayange

et al. 2023

World j. surg.

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Background Defining the optimal timing of operative intervention for pediatric burn patients in a resource-limited environment is challenging. We sought to characterize the association between mortality and the timing of operative intervention at a burn center in Lilongwe, Malawi. Methods This is a retrospective analysis of burn patients (\18 years old) presenting to Kamuzu Central Hospital from 2011 to 2022. We compared patients who underwent excision and/or burn grafting based on the timing of the operation. We used logistic regression modeling to estimate the adjusted odds ratio of death based on the timing of surgery. ResultsWe included 2502 patients with a median age of 3 years (IQR 1-5) and a male preponderance (56.8%). 411 patients (16.4%) had surgery with a median time to surgery of 18 days (IQR 8-34). The crude mortality rate among all patients was 17.0% and 9.1% among the operative cohort. The odds ratio of mortality for patients undergoing surgery within 3 days from presentation was 5.00 (95% CI 2.19, 11.44) after adjusting for age, sex, % total burn surface area (TBSA), and flame burn. The risk was highest for the youngest patients. Conclusions Children who underwent burn excision and/or grafting in the first 3 days of hospitalization had a much higher risk of death than patients undergoing surgical intervention later. Delaying operative intervention till [72 h for pediatric patients, especially those under 5 years old, may confer a survival advantage. More investment is needed in early resuscitation and monitoring for this patient population.

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Section: Discussionmentioning

confidence: 99%

The Timing of Operative Intervention for Pediatric Burn Patients in Malawi

Davis,

An,

Kayange

et al. 2023

World j. surg.

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“…Principally, the focus of this noble campaign is to disseminate information on the social value and clinical need for blood donation [10,15]. Several countries on different continents, e.g., sub-Saharan Africa [20], Bangladesh [21], Brazil, India and the USA [22], which also report similar things with obstacles that are more local in nature.…”

Section: Scientific Approach To Ensure Successful Blood Donationmentioning

confidence: 99%

Organizing Community Participation in Humanitarian Blood Donation Activities

Diani,

Sunarti,

Suryowati

et al. 2023

IBRR

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Aim: To organize and to encourage community participation in humanitarian blood donation held by the Indonesian Red Cross in collaboration with local church. Discussion: The culture of voluntary blood donation must always be encourage, in order to guarantee timely access to safe blood and blood products and help save lives. Compliment and appreciation given to noble donation of voluntary donors who receive no remuneration but are always ready and available to donate blood to help save other lives most of whom they never meet. Using popular social media, action taken to promote, mobilize, and publish educational materials on voluntary blood donation campaigns as well as encourage local potential donor to donate voluntarily. This activity is also the implementation of the noble human values of sharing, giving and caring Conclusion: Connecting all stakeholders helps to make the blood donation succesfull.

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“…3 A number of international and regional programs have been developed to address this by engaging in blood supply and blood safety initiatives. 4 Meanwhile, transfusion medicine research in SSA remains sparse, 5 while blood shortages in this region can have devastating consequences. 6 The purpose of this study was to evaluate and describe the type of blood supply and blood bank/transfusion medicine (BBTM) services available at institutions across Africa.…”

Section: Introductionmentioning

confidence: 99%

“…Given the incidence of conditions requiring transfusion support, in conjunction with a lack of blood donors, some of the countries with the greatest unmet transfusion needs are in sub‐Saharan Africa (SSA) 3 . A number of international and regional programs have been developed to address this by engaging in blood supply and blood safety initiatives 4 . Meanwhile, transfusion medicine research in SSA remains sparse, 5 while blood shortages in this region can have devastating consequences 6 .…”

Section: Introductionmentioning

confidence: 99%

Survey of blood collection and transfusion practices among institutions in Africa

Jacobs,

Stephens,

Milner

et al. 2023

Transfusion

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IntroductionDramatic improvements in blood transfusion have occurred during the last two decades. Transfusion medicine services and practices in Africa remain underexplored.MethodsA survey of blood bank/transfusion medicine (BBTM) practices, available blood products, blood product source(s), pre‐transfusion testing, and blood donor infectious disease testing methodologies across Africa was performed using the American Society for Clinical Pathology (ASCP) listserv. Survey recipients included hospital‐based laboratories/blood banks, national transfusion medicine services, and free‐standing laboratories (collectively referred to as institutions).ResultsResponses from a total of 81 institutions across 22 countries were analyzed. All 81 institutions provide at least one type of blood product—whole blood, red blood cells (RBCs), platelets, plasma, and cryoprecipitate, with whole blood (90.1%, 73 of 81) and RBCs (79.0%, 64 of 81) most common, while cryoprecipitate is least common (12.4%, 10 of 81). Only five countries had a responding institution that provides all types of products. Among institutions that collect blood onsite, the most common sources of blood products are patients' family members (94.1%, 48 of 51) and pre‐screened on‐demand volunteer donors (82.4%, 42 of 51). The most commonly screened infectious agents are HIV and hepatitis B virus (both 81.5%), while 70.4% (57 of 81) test for hepatitis C virus (HCV) and Treponema pallidum.DiscussionThis study highlights significant variability and restrictions in blood product availability, pre‐transfusion testing, and blood donor infectious disease testing across Africa. Further studies are needed to ascertain barriers to improving blood donor availability, blood product safety, and infectious disease testing.

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The BLOODSAFE program: Building the future of access to safe blood in Sub‐Saharan Africa

Cited by 4 publications

References 22 publications

The Timing of Operative Intervention for Pediatric Burn Patients in Malawi

The Timing of Operative Intervention for Pediatric Burn Patients in Malawi

Organizing Community Participation in Humanitarian Blood Donation Activities

Survey of blood collection and transfusion practices among institutions in Africa

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