The blood volume of the normal guinea‐pig

Changes in blood volume and blood picture during the life of the rat and guinea‐pig from birth to maturity

“…Fewer reports on blood volumes of guinea-pigs are available, and, in those which are (Ancill, 1956;Masouredis & Melcher, 1951;Went & Drinker, 1929), variations of between only 6*4 and 8*5 % of the body weight have been reported. Ancill (1956), who studied guinea-pigs of varying body weights, failed to find any significant change in percentage blood volume in animals of between 250 and 750 g body weight.…”

“…These results, however, were similar to those found by Garcia (1957) and Belcher & Harriss (1957) in their experiments with rats. On the other hand, Ancill (1956), who determined blood volumes in guinea-pigs of between 250 and 750 g body weight, found no difference in percentage blood volumes in this range. These differences are at present difficult to explain, and may be due to one or more of several factors, such as strain of animal, diet, or methods of assay.…”

The Effect of Methicillin on Skin Lesions in Guinea-Pigs Caused By "Methicillin-Sensitive" and "Methicillin-Resistant" Staphylococcus Aureus

“…Assuming a plasma volume of 39 ml per kg body weight in the guinea-pig (Ancill, 1956), the maximum theoretically attainable initial serum concentration on these doses would be 40 pg per ml after 1-56 mg per kg and 320 pg per ml after 12.5 mg per kg. The low initial concentrations obtained, and the absence of activity after 2 hours suggest that there was a rapid loss of antibiotic from the serum into the tissues.…”

Hemoglobin-driven pathophysiology is an in vivo consequence of the red blood cell storage lesion that can be attenuated in guinea pigs by haptoglobin therapy

“…Exchanges were performed using separate syringe pumps (model 11, Harvard Apparatus) connected to arterial and venous catheters and were carried out until 80% of each guinea pig's blood volume was replaced. Determination of blood volume was estimated for each animal according to the following equation: blood volume (ml) = (0.07 [ml/g] × body weight [g]) × 0.8 in the guinea pig (40). In a separate group of animals, stromafree guinea pig Hb was infused to achieve a maximum concentration (Cmax = 300 μM) comparable to that observed with animals transfused with old blood for the purpose of assessing acute Hb exposure effects on pathophysiology.…”