The Blood Neutrophil to Lymphocyte Ratio Correlates with Clinical Status in Children with Cystic Fibrosis: A Retrospective Study

O’Brien, Catherine E.; Price, Elvin

doi:10.1371/journal.pone.0077420

Cited by 37 publications

(39 citation statements)

References 22 publications

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“…In children with cystic fibrosis, an elevated N/L ratio was associated with lower body mass index and lower forced expiratory volume in 1 second. It was also implicated as a marker of poorer outcome in these children (15).…”

Section: Discussionmentioning

confidence: 99%

“…White blood cell (WBC) counts, neutrophil counts, lymphocyte counts, age, sex, and mutation types of patients were extracted. The N/L ratio was calculated by dividing the absolute neutrophil counts with the absolute lymphocyte counts, obtained from the differential WBC count (12)(13)(14)(15)(16)(17).…”

Section: Methodsmentioning

confidence: 99%

“…It was shown that inflammation continues not only during attacks but also during symptom-free periods (8)(9)(10)(11). The neutrophil/lymphocyte (N/L) ratio can be easily obtained from the differential white blood cell (WBC) count and has been studied in the context of many diseases (12)(13)(14)(15)(16)(17). It is a marker of inflammation and predicts disease prognosis (7,15).…”

Section: Introductionmentioning

confidence: 99%

“…The neutrophil/lymphocyte (N/L) ratio can be easily obtained from the differential white blood cell (WBC) count and has been studied in the context of many diseases (12)(13)(14)(15)(16)(17). It is a marker of inflammation and predicts disease prognosis (7,15). The diagnosis of FMF is based on clinical features because there are no disease-specific laboratory findings.…”

Section: Introductionmentioning

confidence: 99%

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Neutrophil-lymphocyte ratio in children with familial Mediterranean fever: original article

Duksal¹,

Alaygut²,

Güven³

et al. 2015

Eur J Rheumatol

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Objective: The aim of present study was (a) to evaluate the relationship between the neutrophil/lymphocyte (N/L) ratio and mutation types of familial Mediterranean fever (FMF) in children and (b) to evaluate the relationship between the N/L ratio and age.Material and Methods: Three hundred forty-three children with familial Mediterranean fever in the attack-free period and 283 healthy control children were included in the study. Patients were divided into subgroups according to mutation types. Neutrophil and lymphocyte counts were retrieved from medical records of patients and the N/L ratio was calculated from these parameters. Results:The N/L ratio of patients was found to be significantly higher than that of controls (p<0.001). Among 343 patients, homozygous, heterozygous, and compound mutations were observed in 39, 253, and 51 patients, respectively. The differences in the N/L ratio among patients with homozygous, heterozygous, and compound mutations were not statistically significant. The most common mutations were M694V (n=126), E148Q (n=70), M680I, (n=33), and V726A (n=28). Significant differences were not observed among these mutations in terms of the N/L ratio (p>0.05). In all subjects, there was a weak but significant relationship between age and the N/L ratio (r: 0.215, p<0.001). Conclusion:The N/L ratio, which can be determined by simple methods in routine blood tests, may be used for the follow-up monitoring of chronic inflammation in patients. In addition, the N/L ratio may give an idea to clinicians regarding the early initiation of treatment in patients with typical clinical findings of FMF.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Neutrophil-lymphocyte ratio in children with familial Mediterranean fever: original article

Duksal¹,

Alaygut²,

Güven³

et al. 2015

Eur J Rheumatol

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“…NLR can be easily determined by a simple complete blood count analysis and is a valuable index paramater in diseases such as sudden hearing loss, certain some cancers, autoimmune and cardiovascular diseases [9,10]. Neutrophils are essential for cytokine production in acute process in inflammatory disorders while lymphocyte are important for cytokine production in chronic process in inflammatory disorders.…”

Section: Introductionmentioning

confidence: 99%

The effect of adenoid tissue volume on mean platelet volume and neutrophil-to-lymphocyte ratio

Yeğin¹,

Çelik²,

Altıntaş³

et al. 2017

Otorhinolaryngol Head Neck Sur

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Objectives: To explore the relationships between mean platelet volume (MPV), neutrophil to lymphocyte ratio (NLR) and the size of adenoid hypertrophy(AH) and the effect of adenoidectomy on MPV levels and NLR values. Subjects and methods:In total, 132 (66 males, 66 females; average age 7.10 ± 3.62 years; range, 3-18 years) children who underwent adenoidectomy were included in the study. The patients were divided into two groups according to the size of adenoid tissue volume. Group A was consist of 72 patients with grade 3 AH, while group B was consist of 60 patients with grade 4 AH. Preoperative MPV levels and NLR values of group A and B were compared with measurements in the postoperative third month. A p-value <0.05 was considered to reflect statistical significance. Results:In group A, mean preoperative MPV values were 7.80 ± 1.14 fL and mean postoperative MPV values were 8.06 ± 1.02 fL, respectively. In group B, mean preoperative MPV values were 7.44 ± 1.86 fL and mean postoperative MPV values were 7.68 ± 1.14 fL, respectively. No statistically significant difference in mean MPV values was observed between pre-and postoperatively in both groups A and B (p=0.190, p=0.259, respectively). In group A, the preoperative values of NLR were 1.62 ± 1.10 and the postoperative values of NLR were 1.34 ± 2.86, respectively. In group B, the preoperative values of NLR were 1.38 ± 0.92 and the postoperative values of NLR were 1.40 ± 1.12, respectively. No statistically significant difference in mean NLR values was observed between pre-and postoperatively in both groups A and B (p=0.137, p=0.191, respectively). Conclusion:Adenoidectomy did not decrease MPV levels and NLR values in patients with grade 3 and 4 AH. Future randomized studies should explore the relationship between the MPV levels, NLR values and all of the size of AH in larger numbers of patients.

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The Prognostic Significance of Neutrophil‐to‐Lymphocyte and Platelet‐to‐Lymphocyte Ratios in Patients With Multiple Myeloma

Wongrakpanich

George

Chaiwatcharayut

et al. 2016

Clinical Laboratory Analysis

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The Blood Neutrophil to Lymphocyte Ratio Correlates with Clinical Status in Children with Cystic Fibrosis: A Retrospective Study

Cited by 37 publications

References 22 publications

Neutrophil-lymphocyte ratio in children with familial Mediterranean fever: original article

Neutrophil-lymphocyte ratio in children with familial Mediterranean fever: original article

The effect of adenoid tissue volume on mean platelet volume and neutrophil-to-lymphocyte ratio

The Prognostic Significance of Neutrophil‐to‐Lymphocyte and Platelet‐to‐Lymphocyte Ratios in Patients With Multiple Myeloma

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