The Blood Neutrophil Count After 1 Month of Treatment Predicts the Radiologic Severity of Lung Disease at Treatment End

Jones, Timothy Peter; Dabbaj, Susannah; Mandal, Indrajeet; Cleverley, Joanne; Cash, Charlotte; Lipman, Marc; Lowe, David M.

doi:10.1016/j.chest.2021.07.041

Cited by 7 publications

(7 citation statements)

References 34 publications

(43 reference statements)

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“…Neutrophil and lymphocyte are subtypes leukocyte. Previous studies have shown that neutrophil count is an independent predictor of the radiologic severity of PTB at the end of the treatment period (Jones et al, 2021) and lymphocytopenia represented critical inflammatory states (Li et al, 2021). However, our study had some limitations.…”

Section: Diagnostic Performance Of the Scoring System In The Training...mentioning

confidence: 86%

A scoring system developed from a nomogram to differentiate active pulmonary tuberculosis from inactive pulmonary tuberculosis

Yan

Tian

et al. 2022

Front. Cell. Infect. Microbiol.

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PurposeThis study aimed to develop and validate a scoring system based on a nomogram of common clinical metrics to discriminate between active pulmonary tuberculosis (APTB) and inactive pulmonary tuberculosis (IPTB).Patients and methodsA total of 1096 patients with pulmonary tuberculosis (PTB) admitted to Wuhan Jinyintan Hospital between January 2017 and December 2019 were included in this study. Of these patients with PTB, 744 were included in the training cohort (70%; 458 patients with APTB, and 286 patients with IPTB), and 352 were included in the validation cohort (30%; 220 patients with APTB, and 132 patients with IPTB). Data from 744 patients from the training cohort were used to establish the diagnostic model. Routine blood examination indices and biochemical indicators were collected to construct a diagnostic model using the nomogram, which was then transformed into a scoring system. Furthermore, data from 352 patients from the validation cohort were used to validate the scoring system.ResultsSix variables were selected to construct the prediction model. In the scoring system, the mean corpuscular volume, erythrocyte sedimentation rate, albumin level, adenosine deaminase level, monocyte-to-high-density lipoprotein ratio, and high-sensitivity C-reactive protein-to-lymphocyte ratio were 6, 4, 7, 5, 5, and 10, respectively. When the cut-off value was 15.5, the scoring system for recognizing APTB and IPTB exhibited excellent diagnostic performance. The area under the curve, specificity, and sensitivity of the training cohort were 0.919, 84.06%, and 86.36%, respectively, whereas those of the validation cohort were 0.900, 82.73, and 86.36%, respectively.ConclusionThis study successfully constructed a scoring system for distinguishing APTB from IPTB that performed well.

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Section: Diagnostic Performance Of the Scoring System In The Training...mentioning

confidence: 86%

A scoring system developed from a nomogram to differentiate active pulmonary tuberculosis from inactive pulmonary tuberculosis

Yan

Tian

et al. 2022

Front. Cell. Infect. Microbiol.

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“…Neutrophils have been identified as the most prevalent and predominantly infected cell type in the sputum, bronchoalveolar lavage (BAL) fluid, and caseum contents from resected lung tissue of active tuberculosis (TB) patients ( Condos et al., 1998 ; Eum et al., 2010 ). Increased abundance of neutrophils in whole blood has also been used as a predictor for hospitalization of TB patients and is associated with poor disease outcomes ( Ashitani et al., 2002 ; Berry et al., 2010 ; Ravimohan et al., 2018 ; Scott et al., 2020 ; Jones et al., 2021 ). Together, these studies suggest that neutrophils are associated with TB disease progression.…”

Section: Neutrophils and Their Association With Tuberculosismentioning

confidence: 99%

“…). Increased abundance of neutrophils in whole blood has also been used as a predictor for hospitalization of TB patients and is associated with poor disease outcomes (Ashitani et al, 2002;Berry et al, 2010;Ravimohan et al, 2018;Scott et al, 2020;Jones et al, 2021). Together, these studies suggest that neutrophils are associated with TB disease progression.…”

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confidence: 97%

Exploring the Role of Low-Density Neutrophils During Mycobacterium tuberculosis Infection

Rankin

Hendrix

Naik

et al. 2022

Front. Cell. Infect. Microbiol.

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Tuberculosis (TB) is caused by infection with the bacterium Mycobacterium tuberculosis (Mtb), which primarily infects the lungs but can also cause extrapulmonary disease. Both the disease outcome and the pathology of TB are driven by the immune response mounted by the host. Infection with Mtb elicits inflammatory host responses that are necessary to control infection, but can also cause extensive tissue damage when in excess, and thus must be precisely balanced. In particular, excessive recruitment of neutrophils to the site of infection has been associated with poor control of Mtb infection, prompting investigations into the roles of neutrophils in TB disease outcomes. Recent studies have revealed that neutrophils can be divided into subpopulations that are differentially abundant in TB disease states, highlighting the potential complexities in determining the roles of neutrophils in Mtb infection. Specifically, neutrophils can be separated into normal (NDN) and low-density neutrophils (LDNs) based on their separation during density gradient centrifugation and surface marker expression. LDNs are present in higher numbers during active TB disease and increase in frequency with disease progression, although their direct contribution to TB is still unknown. In addition, the abundance of LDNs has also been associated with the severity of other lung infections, including COVID-19. In this review, we discuss recent findings regarding the roles of LDNs during lung inflammation, emphasizing their association with TB disease outcomes. This review highlights the importance of future investigations into the relationship between neutrophil diversity and TB disease severity.

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“…Several studies suggest that neutrophil accumulation is associated with a dysregulated immune response and a poor prognosis in tuberculosis. Even after bacterial clearance, neutrophil accumulation is linked with post-TB lung disease ( 49 ). Levels of calprotectin, the most abundant neutrophil cytoplasmic protein, and neutrophil chemokines are increased in patients with active tuberculosis compared to healthy controls and those with latent infection, and this is correlated with lung damage ( 47 ).…”

Section: Neutrophils In Mycobacterial Infection and Diseasementioning

confidence: 99%

Antimicrobial Activity of Neutrophils Against Mycobacteria

et al. 2021

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The mycobacterium genus contains a broad range of species, including the human pathogens M. tuberculosis and M. leprae. These bacteria are best known for their residence inside host cells. Neutrophils are frequently observed at sites of mycobacterial infection, but their role in clearance is not well understood. In this review, we discuss how neutrophils attempt to control mycobacterial infections, either through the ingestion of bacteria into intracellular phagosomes, or the release of neutrophil extracellular traps (NETs). Despite their powerful antimicrobial activity, including the production of reactive oxidants such as hypochlorous acid, neutrophils appear ineffective in killing pathogenic mycobacteria. We explore mycobacterial resistance mechanisms, and how thwarting neutrophil action exacerbates disease pathology. A better understanding of how mycobacteria protect themselves from neutrophils will aid the development of novel strategies that facilitate bacterial clearance and limit host tissue damage.

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The Blood Neutrophil Count After 1 Month of Treatment Predicts the Radiologic Severity of Lung Disease at Treatment End

Cited by 7 publications

References 34 publications

A scoring system developed from a nomogram to differentiate active pulmonary tuberculosis from inactive pulmonary tuberculosis

A scoring system developed from a nomogram to differentiate active pulmonary tuberculosis from inactive pulmonary tuberculosis

Exploring the Role of Low-Density Neutrophils During Mycobacterium tuberculosis Infection

Antimicrobial Activity of Neutrophils Against Mycobacteria

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