The Blood Level Determinations of PAS and Isoniazid with Vanillin

Deeb, Edward N.; Vitagliano, Guy R.

doi:10.1002/jps.3030440316

Cited by 16 publications

(4 citation statements)

References 4 publications

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“…A dose of 670 mg isoniazid was infused at a constant rate over 5.48 min. Blood was drawn a t approximately 50-min intervals for 550 min; assays were performed on each sample for isoniazid by the fluorometric method and for isoniazid plus hydrazones by a modification (24) of the vanillin colorimetric method of Deeb and Vitagliano (26). Isoniazid hydrazones were first hydrolyzed to isoniazid in the latter method.…”

Section: Resultsmentioning

confidence: 99%

Determination of Isoniazid and Metabolites in Biological Fluids

Boxenbaum

Riegelman

1974

Journal of Pharmaceutical Sciences

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Section: Resultsmentioning

confidence: 99%

Determination of Isoniazid and Metabolites in Biological Fluids

Boxenbaum

Riegelman

1974

Journal of Pharmaceutical Sciences

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“…The concentrations of phenobarbitone (SVENSMARK & KRISTENSEN 1963), sulphafurazole and acetyl sulphafurazole (VARLEY 1954), mecamylamine (SCHANKER et al 1957, and acetylated and unacetylated isoniazid (DEEB & VITAGLIANO 1955, as modified by TIITINEN et al 1973 were measured spectrophotometrically. Quinidine was assayed fluorimetrically (CRAMER & ISAKSSON 1963).…”

Section: Assay Of Drugsmentioning

confidence: 99%

Effect of Methotrexate on Drug Absorption from the Rat Small Intestine in Situ and in Vitro

Venho

1976

Acta Pharmacologica et Toxicologica

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The effect of methotrexate (20 mg/kg intramuscularly) on the absorption of phenobarbitone, sulphafurazole, mecamylamine, quinidine and isoniazid from the rat small intestine was studied in situ and in vitro. The disappearance of all drugs studied from the intestinal fluid in situ was retarded on the third day after methotrexate administration. The fluid transfer and the amount of drugs passed through the intestinal wall in vitro were also decreased. The absorption of phenobarbitone was reversible within six days, whereas the absorption of quinidine was still retarded on the sixth day after methotrexate administration. Methotrexate did not modify the amount of quinidine excreted into the intestinal lumen after intravenous administration. The levels of other drugs except isoniazid in the blood at the end of the experiment showed changes corresponding to their disappearance from the intestinal lumen. In situ the drug levels in the intestinal wall were much lower than in vitro. Their levels in the intestinal wall reflected drug absorption in vitro but not in situ. The methotrexate‐induced reversible decrease in absorption seems to be attributable at least partly to diminished water flux through the intestinal wall, although other mechanisms may also exist.

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“…Isoniazid concentrations were determined in rabbit blood and in rat lungs, liver, and kidney by the method of Deeb and Vitagliano (1955). In order to eliminate the opalescence in liver samples glycogen was hydrolysed with diastase.…”

Section: Methodsmentioning

confidence: 99%

The Accumulation of Isoniazid in Tissues, and the Course of Experimental Tuberculosis

Vénulet

Jakimowska

Janowiec

et al. 1960

British Journal of Pharmacology and Chemotherapy

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In an attempt to find agents enhancing the infiltration of isoniazid into tissues, the authors have investigated the effect of the drug on oedema due to injection of egg white into the rat paw, when it was given alone and in conjunction with histamine, antazoline, carbachol, chlorpromazine, and a pyrogen. Isoniazid increased the oedema. All the substances, except antazoline, increased the rate at which isoniazid disappeared from the blood, and they all favoured accumulation of the drug in tissues. Treatment of experimental tuberculosis with subthreshold doses of isoniazid, in conjunction with the above compounds, gave better results than when isoniazid was used alone.

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The Blood Level Determinations of PAS and Isoniazid with Vanillin

Cited by 16 publications

References 4 publications

Determination of Isoniazid and Metabolites in Biological Fluids

Determination of Isoniazid and Metabolites in Biological Fluids

Effect of Methotrexate on Drug Absorption from the Rat Small Intestine in Situ and in Vitro

The Accumulation of Isoniazid in Tissues, and the Course of Experimental Tuberculosis

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