The Blood Bank and the Technique and Theropeutics of Transfusions

Kilduffe, Robert A.

doi:10.1097/00007611-194203000-00025

Cited by 13 publications

(9 citation statements)

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“…Yet recovery may follow such a mishap. Kilduffe and DeBakey (1942) give the mortality rate as about 50%. The total incidence of haemolytic reactions due to transfusion of incompatible cells over a large series of cases is very low.…”

mentioning

confidence: 99%

Transfusion Reactions and Fatalities due to Circulatory Overloading

Drummond¹

1943

BMJ

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mentioning

confidence: 99%

Transfusion Reactions and Fatalities due to Circulatory Overloading

Drummond¹

1943

BMJ

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“…The following possibilities were considered : afibrinogenemia secondary to thoracic surgery, anaphylactic shock, blood incompatibility and bacterial contamination of transfused blood. Although we were not able to check the first two possibilities, they were considered to be very unlikely on a statistical basis since both have a very low incidence [8,9]. Blood incompatibility was ruled out.…”

Section: + + -mentioning

confidence: 99%

Profuse Bleeding due to Transfusion of Contaminated Blood - Report of 5 Cases

Sanchez¹,

Gonzalez²,

Mancera³

et al. 1961

Vox Sanguinis

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Reactions due t o the administration of blood contaminated by Gram-negative bacilli are among the most severe risks of blood transfusions. The contaminating microorganisms more commonly responsible for these reactions, Aerobacter, Pseudomonas, Escherichia and Paracolon [l, 4, 11, 13, 141, share the following characteristics: production of very active toxins, ability t o grow at low temperatures and greater resistance than other germs t o the bactericidal effect of blood [l, 2, 3, 51.The purpose of this paper is t o report five such reactions in which massive bleeding was a constant symptom and a prominent factor in the death of three of the patients. Thrombolytic activity was found in a single case with adequate coagulation studies.Description of the reactions. Information concerning age, sex, diagnosis of the primary disease, type of surgical procedure and total amount of transfused blood are given in table I.The reactions were observed in a hospital for pulmonary diseases in a period of one month; they started during surgery (cases 1 , 3 and 5) or shortly thereafter. Death supervened within 3 hours in cases 1 to 3, and on the third day in case 4; patient no. 5 recovered. All patients were under general anesthesia and were receiving a blood transfusion at the time reactions began.Massive generalized bleeding and profound hypotension were the most prominent symptoms. Both lasted until death in patients 1 t o 3;in cases 4 and 5 bleeding stopped after 2 and 8 hours, whereas the hypotensive stage lasted until death in case 4 and for 10 days in the surviving patient. Cyanosis was also a constant and early symptom.Cases (4 and 5) surviving longer, had frequent emesis, profuse perspiration and great restlessness after recovering from anesthesia.

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“…Many forms of therapy have been advocated in the treatment of haemolytic transfusion reactions-e.g., alkaline therapy, forced fluids, transfusion of compatible blood, splanchnic block, and decapsulation of the kidney (Kilduffe and De Bakey, 1942)-but opinions differ on the value of these methods. Few observers are in a position to study a large controlled series of such cases, and this renders assessment of a particular form of therapy difficult.…”

Section: Survival Of the Patientmentioning

confidence: 99%