The Blood Anticoagulant Effect of Short Chain‐length Dextran Sulphates

Ricketts, C. R.

doi:10.1111/j.1476-5381.1954.tb00845.x

Cited by 9 publications

(7 citation statements)

References 7 publications

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“…151 The sulfation of dextran, a branched glucan consisting of -(1 → 6)-glycosidic linkages with -(1 → 3)-linked branches, has long been explored for the development of heparin mimetics with anticoagulant activity. [153][154][155][156][157] Numerous studies have been reported to evaluate the anticoagulant activity of carboxymethyl benzylamide sulfonate dextrans (CMDBS), 113,[158][159][160][161][162][163][164][165] and these have recently been reviewed by Maynard and co-workers. 166 The CMDBS derivatives were found to inhibit thrombin activity via both AT and HCII.…”

Section: Chemical Modification Of Naturally Occurring Polysaccharidesmentioning

confidence: 99%

Heparin mimetics with anticoagulant activity

Al-Nahain

Ignjatović

Monagle

et al. 2018

Medicinal Research Reviews

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Heparin, a sulfated polysaccharide belonging to the glycosaminoglycan family, has been widely used as an anticoagulant drug for decades and remains the most commonly used parenteral anticoagulant in adults and children. However, heparin has important clinical limitations and is derived from animal sources which pose significant safety and supply problems. The ever growing shortage of the raw material for heparin manufacturing may become a very significant issue in the future. These global limitations have prompted much research, especially following the recent well-publicized contamination scandal, into the development of alternative anticoagulants derived from non-animal and/or totally synthetic sources that mimic the structural features and properties of heparin. Such compounds, termed heparin mimetics, are also needed as anticoagulant materials for use in biomedical applications (e.g., stents, grafts, implants etc.). This review encompasses the development of heparin mimetics of various structural classes, including synthetic polymers and non-carbohydrate small molecules as well as sulfated oligo- and polysaccharides, and fondaparinux derivatives and conjugates, with a focus on developments in the past 10 years.

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Section: Chemical Modification Of Naturally Occurring Polysaccharidesmentioning

confidence: 99%

Heparin mimetics with anticoagulant activity

Al-Nahain

Ignjatović

Monagle

et al. 2018

Medicinal Research Reviews

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“…DISCUSSION Thomas and coworkers (9) were able to demonstrate the appearance of an altered form of fibrinogen in the blood of endotoxin-treated rabbits. Ricketts and Walton (10)(11)(12)(13) had previously shown that high molecular weight acidic polysaccharides, of the general class of dextran sulfates, are capable of precipitating fibrinogen directly in vitro, and of producing lesions in animals similar to, if not identical with, those of the generalized Shwartzman reaction. Using these facts, Thomas et al (5,14) showed a synergism between high molecular weight dextran sulfates and endotoxin, in the production of the generalized Shwartzman reaction.…”

Section: Methodsmentioning

confidence: 99%

The Prevention of the Generalized Shwartzman Reaction With Sodium Warfarin

Shapiro

McKay

1958

The Journal of Experimental Medicine

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Using intravenous sodium warfarin, rabbits were rendered hypoprothrombinemic and subjected to two intravenous injections of Shear's polysaccharide. None of the 9 animals surviving the required period of time developed bilateral renal cortical necrosis or histologic thrombi in the kidney, liver, spleen, or lungs. In a control group of 7 animals treated only with endotoxin, 6 developed bilateral renal cortical necrosis. It is concluded that the prothrombin complex is necessary for the production of the generalized Shwartzman reaction by bacterial endotoxins and that this phenomenon is essentially a process of disseminated intravascular coagulation.

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“…395 Intravenously ad¬ ministered heparin disappears quite rapidly from the blood stream. Subcutaneous injec¬ tion prolongs the anticoagulant effect.…”

Section: Radioactive Isotopesmentioning

confidence: 99%