The blobulator: a webtool for identification and visual exploration of hydrophobic modularity in protein sequences
Connor Pitman,
Ezry Santiago-McRae,
Ruchi Lohia
et al.
Abstract:Clusters of hydrophobic residues are known to promote structured protein stability and drive protein aggregation. Recent work has shown that identifying contiguous hydrophobic residue clusters (termed 'blobs') has proven useful in both intrinsically disordered protein (IDP) simulation and human genome studies. However, a graphical interface was unavailable. Here, we present the blobulator: an interactive and intuitive web interface to detect intrinsic modularity in any protein sequence based on hydrophobicity.… Show more
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