The Blastomycosis Bluff by Purpureocillium lilacinum

Lundstrom, Zachary T.; Saleh, Omar M. Abu

doi:10.1016/j.mayocp.2018.12.006

Cited by 2 publications

(3 citation statements)

References 2 publications

(2 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This fungus is largely used in the biological control of plant-parasitic nematodes and insects (Goffr e and Folgarait 2015; Wang et al 2016;Maia Filho et al 2019), and it is noteworthy the risk to the workers when manipulating it, since this fungus is considered an emerging and opportunistic human pathogen. Despite its moderate virulence, it is capable to cause hyalohyphomycosis in immunosuppressed adults (Lundstrom and Abu Saleh 2019;Salazar-Gonz alez et al 2020). However, in the last decade, was observed a significant increase in cases of human hyalohyphomycosis caused by this fungus in immunocompetent individuals (Sharma et al 2015;Turner and Conrad 2015;Evans et al 2016;Guo et al 2019).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Purpureocillium lilacinum an emergent pathogen: antifungal susceptibility of environmental and clinical strains

Corrêa‐Moreira

Neto

Costa

et al. 2022

Letters in Applied Microbiology

View full text Add to dashboard Cite

Purpureocillium lilacinum is a filamentous and hyaline fungus cosmopolitan, saprophytic, largely used in the biological control of plant‐parasitic nematodes and insects, also considered an emerging and opportunistic human pathogen. The standard treatment for hyalohyphomycosis caused by P. lilacinum is not yet defined, since this fungus is resistant to different antifungals, in vitro and in vivo. The aim of this study was to evaluate and compare in vitro antifungal activity against environmental and clinical P. lilacinum isolates and our results demonstrated that these isolates can be resistant to newer generation triazoles, such as voriconazole, and to caspofungin, a drug of the echinocandin class. In summary, we highlight the importance of knowing the different susceptibility profiles of P. lilacinum isolates, and besides that, the emergence of uncommon human and animal opportunistic fungi, such P. lilacinum, especially during COVID‐19, highlight the need for antifungal susceptibility testing of isolates since empirical therapy with different treatment schedules failed in great number of patients.

show abstract

Section: Introductionmentioning

confidence: 99%

“…2019), and it is noteworthy the risk to the workers when manipulating it, since this fungus is considered an emerging and opportunistic human pathogen. Despite its moderate virulence, it is capable to cause hyalohyphomycosis in immunosuppressed adults (Lundstrom and Abu Saleh 2019; Salazar‐González et al . 2020).…”

Section: Introductionmentioning

confidence: 99%

Purpureocillium lilacinum an emergent pathogen: antifungal susceptibility of environmental and clinical strains

Corrêa‐Moreira

Neto

Costa

et al. 2022

Letters in Applied Microbiology

View full text Add to dashboard Cite

show abstract

“…Additionally, the Grocott methenamine silver (GMS) stain is commonly used, since it imparts a black color to the fungal profiles and a pale green color to the background [44]. Due to its ability to sporulate in tissues, P. lilacinum can be confused with Blastomyces dermatitidis, but it is differentiated by the presence of hyphal elements within a tissue biopsy, elevated (1-3)-β-d-glucan, and growth on cultures [45]. In doubtful cases, it is advisable to confirm the diagnosis with MALDI-TOF mass spectrometry, DNA sequencing, or polymerase chain reaction (PCR) amplification of the 18 S RNA [40].…”

Section: Diagnosismentioning

confidence: 99%

Cutaneous Hyalohyphomycosis and Its Atypical Clinical Presentations in Immunosuppressed Patients

Ferara,

Špoljar,

Lugović-Mihić

et al. 2024

Life

View full text Add to dashboard Cite

There has been a substantial increase in the number of cases of invasive fungal infections worldwide, which is associated with a growing number of immunosuppressed patients and a rise in antifungal resistance. Some fungi that were previously considered harmless to humans have become emerging pathogens. One of them is Purpureocillium lilacinum, a ubiquitous filamentous fungus commonly found in the environment, especially in the air and soil. P. lilacinum belongs to a bigger group of hyaline fungi that cause hyalohyphomycosis, a fungal infection caused by fungi with colorless hyphae. Although this is a heterogeneous group of fungi, there are similarities regarding their ubiquity, ways of transmission, affected patients, and difficulties in diagnostics and treatment. In hyalohyphomycosis, the skin is one of the most affected organs, which is why the involvement of dermatologists is crucial for the initial assessment, since the timely recognition and early diagnosis of this condition can prevent life-threatening infections and death. In this review, we covered cutaneous hyalohyphomycosis caused by P. lilacinum and other fungi in the same group, including Fusarium, Penicilium, Scedosporium, Scopulariopsis, Acremonium, and Trichoderma genera.

show abstract

The Blastomycosis Bluff by Purpureocillium lilacinum

Cited by 2 publications

References 2 publications

Purpureocillium lilacinum an emergent pathogen: antifungal susceptibility of environmental and clinical strains

Purpureocillium lilacinum an emergent pathogen: antifungal susceptibility of environmental and clinical strains

Cutaneous Hyalohyphomycosis and Its Atypical Clinical Presentations in Immunosuppressed Patients

Contact Info

Product

Resources

About