The black box of lung redox

Hunt, J.F.

doi:10.1183/09031936.03.00064703

Cited by 2 publications

(2 citation statements)

References 10 publications

(14 reference statements)

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“…Careful review did not reveal any distinguishing characteristics of these patients. Sustained acidopnea unrelated to asthma exacerbation has been observed in active tuberculosis [27], human rhinovirus infection [25], and chronic bronchitis and cystic fibrosis [12,27], suggesting that chronic airway infection could explain persistently low EBC pH; it may also be associated with gastroesophageal reflux [17]. We do not have evidence for a sustained airway infection or reflux in these 2 subjects.…”

Section: Discussionmentioning

confidence: 82%

“…Previous studies have suggested that EBC pH (1) is low in acute, viral respiratory-associated asthma exacerbations [9]; (2) falls during acute viral respiratory infections [25]; (3) increases with systemic corticosteroid therapy [9], and (4) could be affected by gastroesophageal reflux, which can also affect EBC pH [26,27]. In the current study, we found that EBC can be readily collected and stored at home, and that a change in EBC pH was observed in those subjects that failed to wean completely from ICS, but not in those who did not.…”

Section: Discussionmentioning

confidence: 99%

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Changes in Exhaled Nitric Oxide and Breath pH during Fluticasone Wean in Asthma

et al. 2009

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Background: Inhaled corticosteroid (ICS) therapy improves asthma outcome. Both the anti-inflammatory efficacy and toxicities of ICS therapy are dose dependent. Therefore, there is interest in monitoring airway inflammation during ICS dose adjustments. Objective: Fraction of expired nitric oxide (FENO) and exhaled breath condensate (EBC) pH were studied as noninvasive, corticosteroid-responsive markers of airway inflammation. Methods:We prospectively studied the effect of stepwise ICS wean on FENO and EBC pH over 6 months in otherwise healthy adults with moderate persistent asthma. Results:Eighteen subjects completed the initial dose titration and 13 completed the protocol. Of these, 7 weaned off ICS completely and 6 had exacerbations. FENO rose significantly with ICS withdrawal, though there was heterogeneity in the starting level and the degree of rise. EBC pH was collected at home in all subjects and fell more in subjects who had an exacerbation than in those who did not. The decrease in pH was associated with hazard of exacerbation. Conclusion: FENO can be a patient-specific index of airway inflammation during ICS dose titration; change in EBC pH is one home marker that might possibly be used during ICS dose titration. However, additional studies are required.

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Section: Discussionmentioning

confidence: 82%

Section: Discussionmentioning

confidence: 99%

Changes in Exhaled Nitric Oxide and Breath pH during Fluticasone Wean in Asthma

et al. 2009

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Pseudomonas aeruginosaadherence to human basement membrane collagenin vitro

Tsang¹,

Shum²,

Chan³

et al. 2003

Eur Respir J

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The mechanisms for Pseudomonas aeruginosa colonisation in the airways of patients with bronchiectasis and cystic fibrosis are poorly understood. P. aeruginosa could evade mucociliary clearance by adhering to the basement membrane at areas denuded of intact respiratory epithelium.The authors have developed an in vitro model to study P. aeruginosa adherence to human basement membrane type-IV collagen by using scanning electron microscopy. P. aeruginosa adherence density was determined as the number of P. aeruginosa per 20 microscope fields (2,0006) to log inocular size after incubation at 37uC for 45 min.The presence of phytohaemagglutinin (PHA)-E, which binds specifically to D-galactose-b1-4-D-N-acetylglucosamine, significantly reduced P. aeruginosa adherence density compared with control. The presence of heparin and calcium also significantly reduced P. aeruginosa adherence density. P. aeruginosa adherence was not affected by the presence of proline, trans-hydroxyproline, glycine, galactose, N-acetylneuraminic acid, N-acetylglucosamine or Arachis hypogea.Pseudomonas aeruginosa adherence probably acts via recognition of the D-galactoseb1-4-D-N-acetylglucosamine sequence on type-IV collagen and this process could be inhibited by heparin and calcium. As persistent Pseudomonas aeruginosa colonisation is detrimental to patients with cystic fibrosis and bronchiectasis and there is currently no effective treatment for its eradication, these results could lead to novel therapy for persistent Pseudomonas aeruginosa infection. Eur Respir J 2003; 21: 932-938.

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The black box of lung redox

Cited by 2 publications

References 10 publications

Changes in Exhaled Nitric Oxide and Breath pH during Fluticasone Wean in Asthma

Changes in Exhaled Nitric Oxide and Breath pH during Fluticasone Wean in Asthma

Pseudomonas aeruginosaadherence to human basement membrane collagenin vitro

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