The bitter side of teas: Pesticide residues and their impact on human health

Fernandes, Isabela de Andrade Arruda; Maciel, Giselle Maria; Bortolini, Débora Gonçalves; Pedro, Alessandra Cristina; Rúbio, Fernanda; Carvalho, Karina Querne de; Haminiuk, Charles Windson Isidoro

doi:10.1016/j.fct.2023.113955

Cited by 17 publications

(2 citation statements)

References 71 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…embargo, la extracción de fitoquímicos de biomasas agrícolas se puede ver limitada por la presencia de plaguicidas y otros xenobióticos que potencialmente pueden llegar a estar presentes en el producto final, ya que los métodos de extracción de fitonutrientes pueden también extraer a los plaguicidas (Socas et al, 2021). Es por ello que es de vital importancia implementar controles eficientes y rigurosos de calidad e inocuidad principalmente química ya que es bien sabido que la exposición recurrente a plaguicidas puede desencadenar enfermedades crónico degenerativas (Fernandes et al, 2023).…”

Section: Sinunclassified

Determinación del cociente de peligrosidad de plaguicidas presentes en biomasa de chiles (capsicum annuum)

Jiménez Ortega,

Bastidas Bastidas

2023

rayca

View full text Add to dashboard Cite

The state of Sinaloa is one of the largest agricultural producers in Mexico, highlighting the cultivation of pepper for its production volumes and yields. Due to intensive production, significant amounts of biomass (stems and leaves) are released, which are commonly discarded without generating added value, that is why, in recent years, recovery strategies suggest its use as a source of nutraceuticals and phytochemicals. However, if biomasses are contaminated with pesticide residues, they can represent a health risk. The present study aimed to determine the hazard quotient (HQ) and the risk index (HI) of the pesticides identified in poblano, jalapeño, and bell pepper biomasses. For this, the admitted daily intake (ADI), estimated daily intake (EDI), LD50, and the acute reference dose of the identified analytes (ARfD) were used. None of the pesticides in the quantified concentrations represents a risk to human health in their consumption of 0.001 kg per day, this in adults weighing 70 kg, so they could be used for the processing of food supplements and/or extraction of molecules with added value.

show abstract

Section: Sinunclassified

Determinación del cociente de peligrosidad de plaguicidas presentes en biomasa de chiles (capsicum annuum)

Jiménez Ortega,

Bastidas Bastidas

2023

rayca

View full text Add to dashboard Cite

show abstract

“…[12][13][14] Unfortunately, overuse of GCs might lead to the harmful residues in animal tissues and then enter the human body through the food chain, thus causing adverse effects including osteoporosis, endocrine disorders, immunosuppression, and disorders of glucose metabolism. [15][16][17][18] Hence, in order to ensure the human health, the European Union has established the maximum residue limits (MRLs) for GCs in animal tissues and foodstuffs. [19] The MRLs of dexamethasone/betamethasone were 0.75 μg/kg in muscle/kidney of cattle/pigs, and 0.3 μg/kg in milk.…”

Section: Introductionmentioning

confidence: 99%

Comparison of the Glucocorticoid Receptor Binding and Agonist Activities of Typical Glucocorticoids: Insights into Their Endocrine Disrupting Effects

Liang,

Li,

Zhang

et al. 2024

Chemistry & Biodiversity

View full text Add to dashboard Cite

Over the past decades, the synthetic glucocorticoids (GCs) have been widely used in clinical practice and animal husbandry. Given the health hazard of these toxic residues in food, it is necessary to explore the detailed interaction mechanisms of typical GCs and their main target glucocorticoid receptor (GR). Hence, this work compared the GR binding and agonist activities of typical GCs. Fluorescence polarization assay showed that these GCs were potent ligands of GR. Their GR binding affinities were in the order of methylprednisolone > betamethasone ≈ prednisolone > dexamethasone, with IC50 values of 1.67, 2.94, 2.95, and 5.58 nM. Additionally, the limits of detection of dexamethasone, betamethasone, prednisolone, and methylprednisolone were 0.32, 0.14, 0.19, and 0.09 μg/kg in fluorescence polarization assay. Reporter gene assay showed that these GCs induced GR transactivation in a dose‐dependent manner, confirming their GR agonist activities. Among which, dexamethasone at the concentration of 100 nM produced a maximal induction of more than 11‐fold over the blank control. Molecular docking and molecular dynamics simulations suggested that hydrogen‐bonding and hydrophobic interactions played an important role in stabilizing the GC‐GR‐LBD complexes. In summary, this work might help to understand the GR‐mediated endocrine disrupting effects of typical GCs.

show abstract

Nanobiosensors based on on‐site detection approaches for rapid pesticide sensing in the agricultural arena: A systematic review of the current status and perspectives

Srinivasan,

Raajasubramanian,

Ashokkumar

et al. 2024

Biotech & Bioengineering

View full text Add to dashboard Cite

The extensive use of chemical pesticides has significantly boosted agricultural food crop yields. Nevertheless, their excessive and unregulated application has resulted in food contamination and pollution in environmental, aquatic, and agricultural ecosystems. Consequently, the on‐site monitoring of pesticide residues in agricultural practices is paramount to safeguard global food and conservational safety. Traditional pesticide detection methods are cumbersome and ill‐suited for on‐site pesticide finding. The systematic review provides an in‐depth analysis of the current status and perspectives of nanobiosensors (NBS) for pesticide detection in the agricultural arena. Furthermore, the study encompasses the fundamental principles of NBS, the various transduction mechanisms employed, and their incorporation into on‐site detection platforms. Conversely, the assortment of transduction mechanisms, including optical, electrochemical, and piezoelectric tactics, is deliberated in detail, emphasizing its advantages and limitations in pesticide perception. Incorporating NBS into on‐site detection platforms confirms a vital feature of their pertinence. The evaluation reflects the integration of NBS into lab‐on‐a‐chip systems, handheld devices, and wireless sensor networks, permitting real‐time monitoring and data‐driven decision‐making in agronomic settings. The potential for robotics and automation in pesticide detection is also scrutinized, highlighting their role in improving competence and accuracy. Finally, this systematic review provides a complete understanding of the current landscape of NBS for on‐site pesticide sensing. Consequently, we anticipate that this review offers valuable insights that could form the foundation for creating innovative NBS applicable in various fields such as materials science, nanoscience, food technology and environmental science.

show abstract

The bitter side of teas: Pesticide residues and their impact on human health

Cited by 17 publications

References 71 publications

Determinación del cociente de peligrosidad de plaguicidas presentes en biomasa de chiles (capsicum annuum)

Determinación del cociente de peligrosidad de plaguicidas presentes en biomasa de chiles (capsicum annuum)

Comparison of the Glucocorticoid Receptor Binding and Agonist Activities of Typical Glucocorticoids: Insights into Their Endocrine Disrupting Effects

Nanobiosensors based on on‐site detection approaches for rapid pesticide sensing in the agricultural arena: A systematic review of the current status and perspectives

Contact Info

Product

Resources

About