The Birth of first JIPMER “ICSI” Baby

Abstract

Assisted reproductive techniques are becoming more and more essential for human life in the Society. Worldwide more than 5 million babies were born out of this technology after the birth of first baby Louis Brown and second Durga (India) in 1978. It is a boon for the couple in despair to have a child especially when it is provided by Govt Institutions for the less affordable people of the Society. It is essential to share provider's experiences and expectations of the public in a fast growing biomedical field like ART. The techniques of IVF and ICSI have undergone a sea change since the initial technique of natural cycles to ovarian hyper stimulation and stem cell research. A 29 year old lady, Type I Diabetic with hirsutism, PCOS, failed IUI underwent ICSI following ovarian stimulation employing antagonist protocol after 8 years of married life. The husband is also diabetic for 13 years and suffered from post-polio residual paralysis and had asthenospermia. Frozen Embryo transfer of cleavage stage embryos was done on 31.7.2019 after endometrial preparation employing HRT. Her β HCG was HCG 387 on 14.8.2019 and intrauterine pregnancy was confirmed by transvaginal scan. Pregnancy and Diabetes were managed with progesterone support and Insulin therapy respectively. An alive male baby was delivered by emergency Caesarean section on 28.3.2020 at 12.34 PM for breech presentation in labour during lockdown for COVID 19. Both mother and baby were discharged home in healthy condition and the baby is one year old at the time of writing this report.

Medicometric Portrait of Dr. Subhas Mukherjee, Late Recognized Pioneer of Historic Creation of India’s First and World’s Second IVF Baby

“…February 2014(Dhar, 2016); on June 8, 2015, Punji Patel, Mumbai became a mother delivering her son at the age of 60(Dhar, 2015); Mrs. Rajo Devi (aged 70), a resident of Alewa village in Hisar, gave birth her daughter in 2008 and interestingly Mrs. Daljinder Kaur, a 72-year-old woman from Amritsar, Punjab also delivered baby successfully on April 19, 2016(Dhar, 2016) that so far, it has been broken the record of Mrs. Devi for being mother at the age of 70. With help of the invention of Mukherjee's combinations of in vitro fertilization, and cryopreservation of human embryos technique in medically assisted reproduction, more than 5 million test tube babies worldwide see the lights of day (Bhat, 2020) after the birth of Louis Brown (Britain), and Durga (India) in 1978(Bhat, 2020;Dasari and Gopalakrishnan, 2021). Some doctors say that "While the law doesn't stipulate a cut-off age for couples who can undergo IVF, guidelines issued by the Indian Council of Medical Research recommend that the combined age of the couple should not exceed 110.…”