2014
DOI: 10.1098/rstb.2013.0309
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The birth of a new field

Abstract: One contribution of 27 to a Discussion Meeting Issue 'Biology with free-electron X-ray lasers'.

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Cited by 32 publications
(28 citation statements)
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“…The recent advent of femtosecond serial crystallography has demonstrated the capability of collecting complete, high-quality data sets from samples of micrometer or sub-micrometer sized crystals. [10a,19] This approach, however, often requires vast quantities of sample owing to the low efficiency (hit-rate) of the sample delivery system. Acoustic methods, such as those detailed herein, promise to significantly increase the efficiency and throughput of serial crystallography methods as well as more conventional screening and data collection approaches.…”
mentioning
confidence: 99%
“…The recent advent of femtosecond serial crystallography has demonstrated the capability of collecting complete, high-quality data sets from samples of micrometer or sub-micrometer sized crystals. [10a,19] This approach, however, often requires vast quantities of sample owing to the low efficiency (hit-rate) of the sample delivery system. Acoustic methods, such as those detailed herein, promise to significantly increase the efficiency and throughput of serial crystallography methods as well as more conventional screening and data collection approaches.…”
mentioning
confidence: 99%
“…The awareness brought about by the spectacular achievements in ultrafast electron-based science have surely cross-fertilized the field of ultrafast X-ray science, which has been marked by no less spectacular achievements 178 . This is becoming more evident with the development of X-ray free electron lasers (XFELs), 179–181 which are based on high energy electron accelerators. We are even witnessing a convergence of the two branches of ultrafast structural dynamics with several groups increasingly using the MeV electron pulses from XFELs, which have the advantage of overcoming space charge due to their relativistic speeds 182,183 .…”
Section: Discussionmentioning
confidence: 99%
“…The first experiments illuminated a path to achieve room-temperature structures free of radiation damage, from samples too small to provide useful data at synchrotron facilities, as well as providing the means to carry out time-resolved crystallography at femtoseconds to milliseconds. In the five years since, progress has been substantial and rapid, invigorating the field of macromolecular crystallography [4,5]. This phase of development is far from over, but with both the LCLS and the Spring-8 Ångström Compact Free-electron Laser (SACLA) providing facilities for measurements, the benefits of X-ray FELs are already being translated into new biological insights.…”
mentioning
confidence: 99%