The bipolar maze: a roadmap through translational psychopathology

Vieta, Eduard

doi:10.1111/acps.12270

Cited by 52 publications

(26 citation statements)

References 72 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Secondary analyses from our study, looking into 'molecular psychopathology' [49] , showed that bipolar patients with different SIRT1 genotypes presented dissimilar clinical pictures during the severest depressive episode. Particularly, GG carriers showed a higher rate of SB, severer depressive symptoms and psychomotor agitation compared to T carriers, who presented with psychomotor retardation and loss of energy.…”

Section: Discussionmentioning

confidence: 87%

Association between Sirtuin 1 Gene rs10997870 Polymorphism and Suicide Behaviors in Bipolar Disorder

et al. 2016

Self Cite

View full text Add to dashboard Cite

Background/Aims: Suicidal behavior (SB) in bipolar disorder (BD) is a complex multifactorial event resulting from an interaction of genetic, neurobiological and psychosocial factors. Recent studies identified new possible mechanisms, suggesting a role for sirtuins (SIRTs 1-7), a family of nicotinamide adenine dinucleotide-dependent enzymes with a multifaceted role in the central nervous system. The aims of the present study were: (1) to investigate the effects of the rs10997870 SIRT1 gene variant on SB in BD; (2) to explore the effects of the same gene variant on specific depressive symptoms at the severest episode. Methods: One hundred and eighty DSM-IV bipolar outpatients were enrolled in a naturalistic cohort study. The rs10997870 polymorphism within the SIRT1 gene was analyzed. Results: An association between the GG genotype and SB was detected (lifetime: p = 0.015). Compared to other genotypes, GG carriers presented more frequently psychomotor agitation (p = 0.009) and a higher Hamilton Depression Rating Scale total score (p = 0.014) at the severest depressive episode. SB and psychomotor agitation were found to be associated with GG carriers and G allele in a multivariate analysis as well. Conclusion: Our findings suggest a role of the rs10997870 SIRT1 gene variant in SB amongst BD patients and its association with specific depressive symptoms. Despite a number of limitations of this exploratory study, our results may provide new insight into the mechanisms underlying SB in BD.

show abstract

Section: Discussionmentioning

confidence: 87%

Association between Sirtuin 1 Gene rs10997870 Polymorphism and Suicide Behaviors in Bipolar Disorder

et al. 2016

Self Cite

View full text Add to dashboard Cite

show abstract

“…Identifying sensitive periods for the RDoC constructs will improve understanding of environmental pathogenetic components and enhance the precision of stage-related therapeutic interventions (Casey et al, 2014). Changing the paradigm for drug development for bipolar disorders based on the RDoC proposal may counteract the declining assay sensitivity of clinical trials and contribute to moving clinical research toward hard outcomes, such as biomarkers, and ecological measures of functional benefits (Vieta, 2014).…”

Section: Resultsmentioning

confidence: 99%

Toward stratified treatments for bipolar disorders

Hasler¹,

Wolf²

2015

European Neuropsychopharmacology

View full text Add to dashboard Cite

“…If it is severe, diuretics as tiazides or amiloride may be added (indomethacin in resistant cases) [117]. Real-time lithium levels can be obtained with a special point-of-care device which may help to close-monitor those patients that need extra caution [118].…”

Section: Renalmentioning

confidence: 99%

Management of Adverse Effects of Mood Stabilizers

Murru

Popović

Pacchiarotti

et al. 2015

Curr Psychiatry Rep

Self Cite

View full text Add to dashboard Cite

Mood stabilizers such as lithium and anticonvulsants are still standard-of-care for the acute and long-term treatment of bipolar disorder (BD). This systematic review aimed to assess the prevalence of their adverse effects (AEs) and to provide recommendations on their clinical management. We performed a systematic research for studies reporting the prevalence of AEs with lithium, valproate, lamotrigine, and carbamazepine/oxcarbazepine. Management recommendations were then developed. Mood stabilizers have different tolerability profiles and are eventually associated to cognitive, dermatological, endocrine, gastrointestinal, immunological, metabolic, nephrogenic, neurologic, sexual, and teratogenic AEs. Most of those can be transient or dose-related and can be managed by optimizing drug doses to the lowest effective dose. Some rare AEs can be serious and potentially lethal, and require abrupt discontinuation of medication. Integrated medical attention is warranted for complex somatic AEs. Functional remediation and psychoeducation may help to promote awareness on BD and better medication management.

show abstract

The bipolar maze: a roadmap through translational psychopathology

Cited by 52 publications

References 72 publications

Association between Sirtuin 1 Gene rs10997870 Polymorphism and Suicide Behaviors in Bipolar Disorder

Association between Sirtuin 1 Gene rs10997870 Polymorphism and Suicide Behaviors in Bipolar Disorder

Toward stratified treatments for bipolar disorders

Management of Adverse Effects of Mood Stabilizers

Contact Info

Product

Resources

About