The biotransformation of acetophenetidin in the alloxan-diabetic rabbit

Dajani, Rashid M.; Kayyali, S.

doi:10.1016/0010-4035(73)90017-7

Cited by 12 publications

(3 citation statements)

References 20 publications

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“…The effect of sex differences in drug metabolism in abnormal physiological states has been reported by Kato and Gillette (1965), while Reinke et al(l978) have shown altered activity of hepatic mixed function monooxygenase enzymes in streptozotocin induced diabetic rats. Few studies have investigated the effect of diabetes on drug metabolism in vivo (Andrews and Griffiths, 1984;Dajani and Kayyali, 1973;Price and Jollow, 1982) and even fewer have involved the effect of sex differences on drug metabolism in the diabetic state. Few studies have investigated the effect of diabetes on drug metabolism in vivo (Andrews and Griffiths, 1984;Dajani and Kayyali, 1973;Price and Jollow, 1982) and even fewer have involved the effect of sex differences on drug metabolism in the diabetic state.…”

Section: Introductionmentioning

confidence: 99%

“…Most studies on the effect of diabetes on drug metabolism have involved in vitro studies. Few studies have investigated the effect of diabetes on drug metabolism in vivo (Andrews and Griffiths, 1984;Dajani and Kayyali, 1973;Price and Jollow, 1982) and even fewer have involved the effect of sex differences on drug metabolism in the diabetic state.…”

Section: Introductionmentioning

confidence: 99%

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Sex differences in salicylic acid metabolism in streptozotocin induced diabetes in rats

Emudianughe

1990

Fundamemntal Clinical Pharma

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The metabolism of salicylic acid was studied in male and female streptozotocin-induced diabetic Wistar rats. Results obtained showed that in both sexes there was a significant increase in urinary excretion of salicyluric acid in diabetic rats when compared to controls (P less than or equal to 0.001). Within the diabetic groups, there was a significant increase in the urinary excretion of salicyluric acid in the female in comparison to the male rats (P less than or equal to 0.01). A statistically significant increase was observed in urinary excretion of salicyl-glucuronic acid in diabetic female compared to control female rats (P less than or equal to 0.01) while comparison of diabetic male to control male showed a significant decrease in urinary excretion of salicyl-glucuronic acid (P less than or equal to 0.01). Comparison of the diabetic female and male groups showed a high statistically significant difference in urinary excretion of salicyl-glucuronic acid. The diabetic ration, ie diabetic/control was significantly higher in female than in male rats with respect to salicyl-glucuronic acid (P less than or equal to 0.001) and total urinary excretion (P less than or equal to 0.01). The diabetic ratio may likely reflect the true significance of the roles played by the two metabolic pathways. The results suggest sex differences in the metabolism of salicylic acid; this may also be the case in other disease states.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Sex differences in salicylic acid metabolism in streptozotocin induced diabetes in rats

Emudianughe

1990

Fundamemntal Clinical Pharma

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“…Glycosylation of proteins results in perturbation of membrane structure and function, and there is unbridled lipolysis and other, more subtle, changes in intermediary metabolism. Of particular interest to our laboratory has been the observation that the glucuronate-xylulose pathway is abnormal in the tissues of diabetic animals [1][2][3], and that the glucuronidation of drugs and various other substances may be altered in the diabetic-state [4][5][6][7][8][9][10]. Unfortunately, experiments examining drug metabolism in human diabetes have yielded somewhat variable results [11][12][13][14][15][16][17], and there are no unifying hypotheses linking these observations or the findings in animals.…”

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confidence: 99%

Disposition of lorazepam in diabetes: differences between patients treated with beef/pork and human insulins

Herman

Chaudhary

Szakacs

et al. 1995

Eur J Clin Pharmacol

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The pharmacokinetics of lorazepam was examined in 10 male patients with insulin-dependent diabetes mellitus before and following treatment with neomycin and cholestyramine. Neomycin and cholestyramine were given in an attempt to block the enterohepatic circulation of lorazepam and so to permit an in vivo estimate of hepatic glucuronidation. The volume of distribution and clearance of free lorazepam in diabetic patients were not significantly different from the corresponding estimates in 14 normal controls. Neomycin and cholestyramine increased the clearance of lorazepam by 63% consistent with their effect in non-diabetic controls. However, patients on beef/pork insulin exhibited a greater than normal increase on this interupting regimen (125%), and had a significantly greater neomycin/cholestyramine cycling-interrupted clearance of lorazepam than either normal controls or patients on human insulin (15.4 vs. 6.96 and 7.87 ml.min-1.kg-1). The clearance was correlated positively and significantly with HbA1c and glycated proteins (fructosamine), but only in patients on human insulin. Thus, the pharmacokinetics of lorazepam was not altered in patients with insulin-dependent diabetes mellitus. However, it is possible that there are differences in the rate and extent of hepatic glucuronidation and enterohepatic circulation of lorazepam between patients treated with beef/pork and human insulins and between diabetics treated with beef/pork insulin and non-diabetic controls.

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Diabetes alters drug metabolism-in vivo studies in a streptozotozin-diabetic rat model

Zysset

Sommer

1986

Experientia

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The biotransformation of acetophenetidin in the alloxan-diabetic rabbit

Cited by 12 publications

References 20 publications

Sex differences in salicylic acid metabolism in streptozotocin induced diabetes in rats

Sex differences in salicylic acid metabolism in streptozotocin induced diabetes in rats

Disposition of lorazepam in diabetes: differences between patients treated with beef/pork and human insulins

Diabetes alters drug metabolism-in vivo studies in a streptozotozin-diabetic rat model

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