The Biotechnological Potential of Secondary Metabolites from Marine Bacteria

Abstract

Marine habitats are a rich source of molecules of biological interest. In particular, marine bacteria attract attention with their ability to synthesize structurally diverse classes of bioactive secondary metabolites with high biotechnological potential. The last decades were marked by numerous discoveries of biomolecules of bacterial symbionts, which have long been considered metabolites of marine animals. Many compounds isolated from marine bacteria are unique in their structure and biological activity. Their study has made a significant contribution to the discovery and production of new natural antimicrobial agents. Identifying the mechanisms and potential of this type of metabolite production in marine bacteria has become one of the noteworthy trends in modern biotechnology. This path has become not only one of the most promising approaches to the development of new antibiotics, but also a potential target for controlling the viability of pathogenic bacteria.

Biogenic Silver Nanoparticles Synthesis from New Record Aquatic Bacteria of Nile Tilapia and Evaluation of their Biological Activity

“…Most species of Bacillus members consider good sources of biologically active compounds, in particular enzyme inhibitors, therapeutic proteins, antibiotics, and bioactive pharmacological agents (Perez et al 2017). They produce bioactive metabolites with vast numbers of secondary antimicrobial metabolites, as well as bio-peptides with varied diversity and chemical structures (Andryukov et al 2019).). Although most of these compounds are bioactive against Gram-positive bacteria, some of them have a wide range of bioactivity towards Gram-negative bacteria and filamentous fungi, such as bacteriocins, bacteriocin-like substances and lipopeptides (Silva et al 2018).…”

Food Metabolites as Tools for Authentication, Processing, and Nutritive Value Assessment

“…Bacteria secondary metabolites biosynthesis occurs in the last phase of growth (stationary phase). These microorganisms are capable of producing multiple molecules with distinct biological functions, such as pigments, hormones, toxins, pesticides, immunosuppressants, antibacterial, and anticancer compounds [ 37 , 49 ]. Some examples are bacteriocins (antibacterial), siderophores (antibiotics), terpenoids, antimycins (fungicidal), geldanamycin (antibiotic), prodigiosin (pharmacological effects), and vancomycin (antibiotic).…”

Deep Hypersaline Anoxic Basins as Untapped Reservoir of Polyextremophilic Prokaryotes of Biotechnological Interest

“…Generally, marine microorganisms represent an untapped source for the discovery and development of new biomolecules due to their rich biodiversity and genetic capacity to produce unique metabolites [73][74][75]. In this regard, it is well documented that many taxonomically novel marine species are promising sources of new bioactive compounds with noteworthy pharmaceutical activities, which can become sources of novel therapeutic agents [52,76]. In particular, marine extreme environments, like deep-sea and polar ecosystems or DHABs, have been revealed to be a rich source of secondary metabolites with novel structures and outstanding biological activities [28,52,77].…”