“…The continuity of these reviews, which now span fifteen years, is maintained through appropriate reference to earlier Reports and to other reviews. [1][2][3][4][5][6][7] In part, comprehensive access to the literature was gained through the valuable ISI Data Service at Bath. A review has been published 8 which is centred around the biosynthesis of bioactive compounds and useful macrolide antibiotics and polyketides, and the transformation of these metabolites into new compounds by microbial conversion or gene manipulation.…”