The Biosynthesis of Hemoglobin From Iron, Protoporphyrin and Globin*†

An Intracellular Protein Intermediate for Hemoglobin Formation*

“…This soluble protein appears to be the vehicle by which iron is moved from fixed stromal pools to hemoglobin. The relationship, if any, of this soluble protein to the "heme synthetase system" and, especially, "fraction II" described by Schwartz and colleagues (24) remains to be elucidated.…”

“…Several lines of evidence have suggested the presence of an intracellular, nonheme iron protein that may be an intermediate in the formation of hemoglobin (1)(2)(3)(4)(5)(6)(7)(8)(9)(10). This report describes a protein fraction from human and dog marrow cells which appears from isotopic studies to be such a precursor of hemoglobin.…”

In Vitro Pyrrole and Porphyrin Synthesis in Lead Poisoning and Iron Deficiency*

“…As a result of the efforts of a number of investigators, whose work is summarized in Figure 1, a pathway for the biosynthesis of heme has been outlined (6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23).…”

Iron Deficiency Anemia: A Public Health Problem of Global Proportions

“…Synthesis of Hb involves a series of complex steps occurring in the erythrocytes, with production continuing through the early phases of the development and maturation of red blood cells (London et al, 1964). The coordinated production of heme, the group that mediates reversible oxygenation, and globin, which is responsible for protection of the heme group during transport, is required during synthesis (Schwartz et al, 1961).…”