The Biosynthesis of Gramicidin S. A Restudy<sup>*</sup>

Bhagavan, N.V.; Rao, Prema M.; Pollard, Leonard W.; Rao, R. K.; Winnick, Theodore; Hall, John B.

doi:10.1021/bi00876a015

Cited by 36 publications

(3 citation statements)

References 11 publications

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“…The development of cell-free systems active in the biosynthesis of gramicidin S and the tyrocidines has played an important role in attempts to decipher the mechanism of peptide antibiotic synthesis. Many laboratories agreed (Yukioka et al, 1965;Berg et al, 1966;Bhagavan et al, 1966;Tomino et al, 1967;Fujikawa et al, 1968a), and we confirmed (Gevers et al, 1968) that this type of synthesis occurs in the complete absence of polynucleotides. This indicates that the amino acid sequence in these antibiotics is determined by enzyme specificity and organization and not by RNA templates.…”

supporting

confidence: 85%

Tyrocidine biosynthesis by three complementary fractions from Bacillus brevis (ATCC 8185)

Lipmann¹,

Roskoski²,

Gevers³

et al. 1970

Biochemistry

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supporting

confidence: 85%

Tyrocidine biosynthesis by three complementary fractions from Bacillus brevis (ATCC 8185)

Lipmann¹,

Roskoski²,

Gevers³

et al. 1970

Biochemistry

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“…Evidence has been accumulating which showed that the biosyntheses of these peptides were catalyzed only with the soluble fractions obtained from Bacillus brevis strains and were not affected by the inhibitors of protein synthesis (Mach et al, 1963;March, 1963;Yukioka et al, 1965;Berg et al, 1965;Fujikawa et al, 1966). The concept in support of the ribosomal pathway for the synthesis of these peptides which had been contradictory to the above findings for past few years (Uemura et al, 1963;Okuda et al, 1964;Bodley et al, 1964;Uemura et al, 1965;Hall et al, 1965) has recently been retracted by Bhagavan et al (1966) of the same group, reporting that they have obtained a soluble enzyme system for the synthesis of gramicidin S different from their previous one.…”

mentioning

confidence: 89%

Cell-Free Synthesis of Gramicidin S^*

Tomino¹,

Yamada²,

Itoh³

et al. 1967

Biochemistry

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“…It was inhibited by puromycin and chloramphenicol and was RNAase sensitive. As the galley proof for this review was being examined, a paper entitled "The Biosynthesis of Gramicidin S. A Restudy" was published by WINNICK'S laboratory (BHAGAVAN, RAo, POLLARD, RAo, WINNICK and HALL, 1966). It was reported that they were unable to repeat the previous experiments which had indicated that a ribosomal system was involved in peptide antibiotic synthesis and, consequently, a reassessment of the earlier reports was made.…”

mentioning

confidence: 99%

Biosynthesis

1967

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All rights, especially that of translation into f oreign 1anguages, reserved. It is also forbidden to reproduce this book, either who1e or in part, by photomechanical means (photostat, microfilm and/or microcard) or by other procedure without written pennission from Springcr-Vcrlag Berlin Heide1bCig GmbH. DedicationFor most areas of scientific pursuit, there is usually that rare investigator who has the imagination to conceive ideas, who has faith in his visions, and who has the ability to critically test his concepts in the laboratory. Almost invariably, this scientist also inspires younger men to enthusiastically enter into his research program. To him should go the accolades and the recognitions of the esteem in which he is held. As only a small part of this esteem, we wish to dedicate these books to Professor SELMAN A. W AKSMAN in appreciation of his leadership and contributions in all facets of antibiotic research. PrefaceThe idea for publishing these books on the mechanism of action and on the biosynthesis of antibiotics was born of frustration in our attempts to keep abreast of the literature. Gone were the years when we were able to keep a bibliography on antibiotics and feel confident that we could find everything that was being published on this sUbject. These fields of investigation were moving forward so rapidly and were encompassing so wide a range of specialized areas in microbiology and chemistry that it was almost impossible to keep abreast of developments. In our naivete and enthusiasm, however, we were unaware that we were toying with an idea that might enmesh us, that we were creating an entity with a life of its own, that we were letting loose a Golom who instead of being our servant would be our master.That we set up ideals for these books is obvious; they would be current guides to developments and information in the areas of mechanism of action and biosynthesis of antibiotics. For almost every subject, we wished to enlist the aid of an investigator who himself had played a part in determining the nature of the phenomena that were being discussed. One concept for the books was that they include only antibiotics for which a definitive, well-documented mechanism of action or biosynthetic pathway was known. Yet, such an approach would not entirely serve the purpose we projected, for it would not encompass all of the information available in these fields of antibiotic investigations and blind searches for the original literature would still have to be made. We therefore chose to include any and all antibiotics about which some pertinent information had been published. It was obvious even at the start that such a compilation, integration, and analysis of information could never be complete unless scientific investigations ceased at the moment the last manuscript was submitted-an end that was neither desirable nor possible. An addendum was therefore included at the end of the volume and left open for the addition of new information until the last pages of the regular articles had been printed.The...

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The Biosynthesis of Gramicidin S. A Restudy^*

Cited by 36 publications

References 11 publications

Tyrocidine biosynthesis by three complementary fractions from Bacillus brevis (ATCC 8185)

Tyrocidine biosynthesis by three complementary fractions from Bacillus brevis (ATCC 8185)

Cell-Free Synthesis of Gramicidin S^*

Biosynthesis

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The Biosynthesis of Gramicidin S. A Restudy*

Cited by 36 publications

References 11 publications

Tyrocidine biosynthesis by three complementary fractions from Bacillus brevis (ATCC 8185)

Tyrocidine biosynthesis by three complementary fractions from Bacillus brevis (ATCC 8185)

Cell-Free Synthesis of Gramicidin S*

Biosynthesis

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Product

Resources

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The Biosynthesis of Gramicidin S. A Restudy^*

Cell-Free Synthesis of Gramicidin S^*