The BioStent: Novel Concept for a Viable Stent Structure

Abstract

The BioStent concept is a platform technology offering a novel opportunity to generate a viable, self-expanding stent structure with a functional endothelial cell lining. This platform technology can be transferred to different applications depending on the luminal cell lining required.

FMN-Coated Fluorescent USPIO for Cell Labeling and Non-Invasive MR Imaging in Tissue Engineering

“…Medium flow through the graft was gradually increased from 20 to 200 ml/min over a 14-day conditioning period, with physiological pressure conditions (120 mm Hg, systolic pressure; 80 mm Hg, diastolic pressure) also maintained over the conditioning period. After 14 days of cultivation, FLUSPIO labeled ovine carotid artery endothelial cells (16x 10 6 per graft) were seeded on the luminal surface of the graft as described previously 28. The conditioned vascular composite graft (plus outer mold cylinder) was disconnected from the bioreactor system and filled with endothelial medium containing 16 x 10 6 ovine carotid artery-derived endothelial cells.…”

TexMi: Development of Tissue-Engineered Textile-Reinforced Mitral Valve Prosthesis

“…Fibrin-based TEHVs implanted in the pulmonary circulation of the sheep model have shown the absence of thromboembolism, hemorrhagic complications, calcifications, stenosis, rejection, and transmission of infection. 23,24 Furthermore, complete in vivo 23 and in vitro 38 endothelialization of fibrin-based tissue-engineered constructs providing optimal hemocompatibility has also been shown and the application of a textile-reinforced fibrin-based vascular graft in the arterial circulation has been demonstrated. 25 These results, together with the ease of fabrication, the functionality, and the considerable ECM synthesis shown for the TexMi in this article, are encouraging toward the realization of a tissueengineered textile-reinforced mitral valve with (1) shape mimicking the native 3D valvular anatomy, (2) preservation of the myocardial function through the chordae tendineae, (3) physiological hemodynamics, (4) physiological hemocompatibility, (5) adequate mechanical properties to withstand the high stress of the systemic circulation, and (6) remodeling and self-repair capability.…”

The influence of porosity on the hemocompatibility of polyhedral oligomeric silsesquioxane poly (caprolactone-urea) urethane

“…To evaluate the kinetic coagulation process from contact activation to clot formation, we tested our samples for coagulation, platelet adhesion and whole blood responses. TEG was applied to study the extent of contact activation and the clotting cascade (Weinandy et al , 2012).…”