“…4,25,29 The literature contains a number of reports of the reaction of iron or haem with artemisinin or related endoperoxides. 5,14,15,26,27,30,31 However, the use of significantly different reaction conditions, such as solvent composition, iron salt form, reagent concentration, and temperature, has resulted in conflicting reports of the preferential degradation pathway and relative reactivity of artemisinin and its analogs. Furthermore, attempts to correlate iron reactivity with antimalarial activity may also be unreliable due to the effect of reaction conditions that all differ significantly from the biological situation.…”