The biomedical potential of cellulose acetate/polyurethane nanofibrous mats containing reduced graphene oxide/silver nanocomposites and curcumin: Antimicrobial performance and cutaneous wound healing

Esmaeili, Elaheh; Eslami-Arshaghi, Tarlan; Hosseinzadeh, Simzar; Elahirad, Elnaz; Jamalpoor, Zahra; Hatamie, Shadie; Soleimani, Masoud

doi:10.1016/j.ijbiomac.2020.02.295

Cited by 116 publications

(77 citation statements)

References 59 publications

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“…The in vitro antimicrobial analysis of the drug co-loaded nanofibrous mats demonstrated a high synergistic antibacterial activity against S. aureus and Pseudomonas bacteria when compared to the drug-loaded mats. The in vivo wound closure experiments of dual drug-loaded polymeric nanofibrous mats demonstrated a significantly accelerated wound healing rate resulting in a 100% wound healing when compared to 78% for the control (plain nanofibrous mats), 90% for the graphene oxide-loaded mats and 93% for the Ag loaded mats [ 140 ].…”

Section: Curcumin-loaded Wound Dressingsmentioning

confidence: 99%

Polymer-Based Materials Loaded with Curcumin for Wound Healing Applications

2020

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Some of the currently used wound dressings have interesting features such as excellent porosity, good water-absorbing capacity, moderate water vapor transmission rate, high drug loading efficiency, and good capability to provide a moist environment, but they are limited in terms of antimicrobial properties. Their inability to protect the wound from microbial invasion results in wound exposure to microbial infections, resulting in a delayed wound healing process. Furthermore, some wound dressings are loaded with synthetic antibiotics that can cause adverse side effects on the patients. Natural-based compounds exhibit unique features such as good biocompatibility, reduced toxicity, etc. Curcumin, one such natural-based compound, has demonstrated several biological activities such as anticancer, antibacterial and antioxidant properties. Its good antibacterial and antioxidant activity make it beneficial for the treatment of wounds. Several researchers have developed different types of polymer-based wound dressings which were loaded with curcumin. These wound dressings displayed excellent features such as good biocompatibility, induction of skin regeneration, accelerated wound healing processes and excellent antioxidant and antibacterial activity. This review will be focused on the in vitro and in vivo therapeutic outcomes of wound dressings loaded with curcumin.

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Section: Curcumin-loaded Wound Dressingsmentioning

confidence: 99%

Polymer-Based Materials Loaded with Curcumin for Wound Healing Applications

2020

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“…There was a continuous decrease in the water contact angle concomitant with the increase in rGO measuring at 82.7°, 80.2° and 74.1° for PCL0.5rGO, PCL1rGO, and PCL3rGO, respectively with statistical significance observed in between all study groups. The capability of rGO and the GFMs, in general, to increase substrate hydrophilicity is well-documented and is considered a critical factor that affects the biocompatibility of graphene-based materials and their interactions with cells 38,[50][51][52][53][54] .…”

Section: Morphological Characterization Of the 3d Printed Scaffoldsmentioning

confidence: 99%

Fabrication and characterization of mechanically competent 3D printed polycaprolactone-reduced graphene oxide scaffolds

Seyedsalehi

Daneshmandi

Barajaa

et al. 2020

Sci Rep

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The ability to produce constructs with a high control over the bulk geometry and internal architecture has situated 3D printing as an attractive fabrication technique for scaffolds. Various designs and inks are actively investigated to prepare scaffolds for different tissues. In this work, we prepared 3D printed composite scaffolds comprising polycaprolactone (PCL) and various amounts of reduced graphene oxide (rGO) at 0.5, 1, and 3 wt.%. We employed a two-step fabrication process to ensure an even mixture and distribution of the rGO sheets within the PCL matrix. The inks were prepared by creating composite PCL-rGO films through solvent evaporation casting that were subsequently fed into the 3D printer for extrusion. The resultant scaffolds were seamlessly integrated, and 3D printed with high fidelity and consistency across all groups. This, together with the homogeneous dispersion of the rGO sheets within the polymer matrix, significantly improved the compressive strength and stiffness by 185% and 150%, respectively, at 0.5 wt.% rGO inclusion. The in vitro response of the scaffolds was assessed using human adipose-derived stem cells. All scaffolds were cytocompatible and supported cell growth and viability. These mechanically reinforced and biologically compatible 3D printed PCL-rGO scaffolds are a promising platform for regenerative engineering applications.

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“…Graphene and graphene derivatives can be attached to other surfaces as coatings for example by electrical and chemical deposition methods, [14–16,38–40] layer‐by‐layer assembly [41,42] or various surface spreading methods [43–48] . Finally, gel spinning, [49] electrospinning, [50,51] layer‐by‐layer assembly [41,52,53] or melt extrusion [54] have been used to create graphene based antibacterial nanocomposites. The method of obtaining the antibacterial surfaces is essential as it dictates the extent to which such surfaces can be tuned in terms of orientation and distribution of the graphene and their upscaling potential.…”

Section: Graphene‐based Antimicrobial Surfacesmentioning

confidence: 99%

Graphene‐Based Antimicrobial Biomedical Surfaces

et al. 2020

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Biomedical application of graphene derivatives have been intensively studied in last decade. With the exceptional structural, thermal, electrical, and mechanical properties, these materials have attracted immense attention of biomedical scientists to utilize graphene derivatives in biomedical devices to improve their performance or to achieve desired functions. Surfaces of graphene derivatives including graphite, graphene, graphene oxide and reduce graphene oxide have been demonstrated to pave an excellent platform for antimicrobial behavior, enhanced biocompatibility, tissue engineering, biosensors and drug delivery. This review focuses on the recent advancement in the research of biomedical devices with the coatings or highly structured polymer nanocomposite surfaces of graphene derivatives for antimicrobial activity and sterile surfaces comprising an entirely new class of antibacterial materials. Overall, we aim to highlight on the potential of these materials, current understanding and knowledge gap in the antimicrobial behavior and biocompatibility to be utilized of their coatings to prevent the cross infections.

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The biomedical potential of cellulose acetate/polyurethane nanofibrous mats containing reduced graphene oxide/silver nanocomposites and curcumin: Antimicrobial performance and cutaneous wound healing

Cited by 116 publications

References 59 publications

Polymer-Based Materials Loaded with Curcumin for Wound Healing Applications

Polymer-Based Materials Loaded with Curcumin for Wound Healing Applications

Fabrication and characterization of mechanically competent 3D printed polycaprolactone-reduced graphene oxide scaffolds

Graphene‐Based Antimicrobial Biomedical Surfaces

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