The biomechanical and morphological changes in the medial collateral ligament of the rabbit after immobilization and remobilization.

Woo, Savio L.-Y.; Gomez, Mark A.; Sites, Terry J.; Newton, Peter O.; Orlando, Carlo A.; Akeson, Wayne H.

doi:10.2106/00004623-198769080-00014

Cited by 348 publications

(176 citation statements)

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“…It has been well established that mechanical stimuli are essential for the normal maintenance of ligament, tendon, and bone integrity [22][23][24][25][26][27][28][29] . Stress deprivation decreases collagen organization and ultimate tissue strength 27 .…”

Section: Discussionmentioning

confidence: 99%

Effect of Immediate and Delayed High-Strain Loading on Tendon-to-Bone Healing After Anterior Cruciate Ligament Reconstruction

Packer

Bedi

Fox

et al. 2014

Journal of Bone and Joint Surgery

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Section: Discussionmentioning

confidence: 99%

Effect of Immediate and Delayed High-Strain Loading on Tendon-to-Bone Healing After Anterior Cruciate Ligament Reconstruction

Packer

Bedi

Fox

et al. 2014

Journal of Bone and Joint Surgery

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“…Immobilization studies on collateral and cruciate ligaments revealed rapid declines in the mechanical properties of both the bone-ligament-bone complex and the ligament substance [3,12,20,25]. Severe cruciate ligament injuries produced considerable osteoporosis in the affected knee [I 11.…”

Section: Discussionmentioning

confidence: 99%

Mechanical properties of the scapholunate ligament correlate with bone mineral density measurements of the hand

Johnston

Small

Bouxsein

et al. 2004

Journal Orthopaedic Research

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The mechanical properties of the scapholunate ligament have been previously examined in small sample sizes, with ultimate load and occasionally stiffness reported. The present study examined 16 scapholunate ligaments in uniaxial extension at two rates and determined stiffness, ultimate load, and stress relaxation properties. Mean stiffness values of 66.4 k 28.6 N/mm at an elongation rate of 50 mm/min and 94.5 ? 44.4 Nlmm at an elongation rate of 100 mmlmin were found. Relaxation behavior, determined by the percent load remaining after 100 s, was found to be 68.1 k 12% Mean ligament ultimate loads were 357 k 110 N ( n = 8). In eight specimens, failure occurred in bone. Positive correlations were observed between bone mineral density of the hand and ligament stiffness, ligament ultimate load, and bone ultimate load. No correlation was observed between bone mineral density and ligament load relaxation behavior. The results provide a comprehensive understanding of scapholunate ligament biomechanics and demonstrate a relationship between bone and ligament properties.

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“…Its formation requires bone remodeling at the interface side as well as at the deep marrow layer. Few researchers have reported bone remodeling associated with recovery of the bone-tendon interface [32]. Formation of a cancellous bed might release trophic substances such as TGFPl [12,15,17] and thereby cause active bone remodeling.…”

Section: Discussionmentioning

confidence: 99%

Early anchoring collagen fibers at the bone—tendon interface are conducted by woven bone formation: light microscope and scanning electron microscope observation using a canine model

Oguma

Murakami

Takahashi-Iwanaga

et al. 2001

Journal Orthopaedic Research

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To clarify the early process of recovery at the bone-tendon interface, we used light microscopy and SEM to examine the process of anchoring of collagen fibers to bone in a canine model.At two weeks, tendon, scar tissue, woven bone and lamellar bone were present at the insertion site. SEM revealed anchoring of collagen fibril bundles of the scar to the woven bone. By 4 weeks, the number of anchoring fibers had increased and a parallel arrangement of fibers was observed. SEM demonstrated deep penetration of fibers into the woven bone layer. In addition, the fibers were observed to project into and intermingle with the scar tissue. By 6 weeks, the anchoring fibers had developed fully and were distributed densely over the interface. SEM also revealed that the collagen fibril bundles in the scar tissue had connected with the collagen fibrils of the woven bone by way of the anchoring bundles. The woven bone was identifiable throughout the early stages of recovery as the interface between soft tissue and hard tissue. Throughout all experimental periods, no staining was observed at the interface of the tendon and bone by Saffranin-0. The formation of woven bone was important during early recovery of the tendonbone interface prior to the completion of fibrocartilage-mediated insertion. 0

show abstract

The biomechanical and morphological changes in the medial collateral ligament of the rabbit after immobilization and remobilization.

Cited by 348 publications

References 0 publications

Effect of Immediate and Delayed High-Strain Loading on Tendon-to-Bone Healing After Anterior Cruciate Ligament Reconstruction

Effect of Immediate and Delayed High-Strain Loading on Tendon-to-Bone Healing After Anterior Cruciate Ligament Reconstruction

Mechanical properties of the scapholunate ligament correlate with bone mineral density measurements of the hand

Early anchoring collagen fibers at the bone—tendon interface are conducted by woven bone formation: light microscope and scanning electron microscope observation using a canine model

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