The Biology of Human Resilience: Opportunities for Enhancing Resilience Across the Life Span

Feder, Adriana; Fred-Torres, Sharely; Southwick, Steven M.; Charney, Dennis S.

doi:10.1016/j.biopsych.2019.07.012

Cited by 179 publications

(160 citation statements)

References 152 publications

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“…Finally, it is important to study the neurobiological substrates of resilience, which underly the behavioral phenotypes observed in our study. There are recent reviews about the causes of resilience that highlight the importance of neuroplasticity in several brain networks, changes at the blood-brain barrier, genetic factors, and the role of the immune system, the metabolism and the gut microbiota (Cathomas et al, 2019;Feder et al, 2019;Holz et al, 2019;Tsyglakova et al, 2019;Turkson et al, 2019). Based on previous studies in our laboratory, we propose that a reduced inflammatory response, epigenetic changes (lower histone acetylation activity), reduced permeability of the BBB, and lower glutamate activity in the brain reward system may mediate the phenotype of resilience to the effects of RSD on cocaine reward (Montagud-Romero et al, 2016aRodríguez-Arias et al, 2017;García-Pardo et al, 2019).…”

Section: Resultsmentioning

confidence: 99%

Behavioral Traits Associated With Resilience to the Effects of Repeated Social Defeat on Cocaine-Induced Conditioned Place Preference in Mice

Calpe-López

García-Pardo

Martínez-Caballero

et al. 2020

Front. Behav. Neurosci.

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The relationship between stress and drug use is well demonstrated. Stress-induced by repeated social defeat (RSD) enhances the conditioned place preference (CPP) induced by cocaine in mice. The phenomenon of resilience understood as the ability of subjects to overcome the negative effects of stress is the focus of increasing interest. Our aim is to characterize the behavior of resilient animals with respect to the effects of RSD on the CPP induced by cocaine. To this end, 25 male C57BL/6 mice were exposed to stress by RSD during late adolescence, while other 15 male mice did not undergo stress (controls). On the 2 days following the last defeat, all the animals carried out the elevated plus maze (EPM) and Hole Board, Social Interaction, Tail Suspension and Splash tests. Three weeks later, all the animals performed the CPP paradigm with a low dose of cocaine (1 mg/kg). Exposure to RSD decreased all measurements related to the open arms of the EPM. It also reduced social interaction, immobility in the tail suspension test (TST) and grooming in the splash test. RSD exposure also increased the sensitivity of the mice to the rewarding effects of cocaine, since only defeated animals acquired CPP. Several behavioral traits were related to resilience to the potentiating effect of RSD on cocaine CPP. Mice that showed less submission during defeat episodes, a lower percentage of time in the open arms of the EPM, low novelty-seeking, high social interaction, greater immobility in the TST and a higher frequency of grooming were those that were resilient to the long-term effects of social defeat on cocaine reward since they behaved like controls and did not develop CPP. These results suggest that the behavioral profile of resilient defeated mice is characterized by an active coping response during episodes of defeat, a greater concern for potential dangers, less reactivity in a situation of inevitable moderate stress and fewer depressive-like symptoms after stress. Determining the neurobehavioral substrates of resilience is the first step towards developing behavioral or pharmacological interventions that increase resilience in individuals at a high risk of suffering from stress.

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Section: Resultsmentioning

confidence: 99%

Behavioral Traits Associated With Resilience to the Effects of Repeated Social Defeat on Cocaine-Induced Conditioned Place Preference in Mice

Calpe-López

García-Pardo

Martínez-Caballero

et al. 2020

Front. Behav. Neurosci.

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“…Despite the challenges of the current pandemic, our collective experiences with coping may cultivate resilience and reveal opportunities for creating more flexible and better care in the future. Resilience is a process of interactive adaptation that facilitates coping in the face of adversity linked with a person’s neurological and psychological makeup [ 47 ], and, equally (if not more) importantly, the socio-ecological contexts [ 48 ]. Past research in families of autistic individuals has shown that resilience is associated with social support, coping style (e.g., problem-focused coping), cognitive appraisal, optimism, locus of control, self-efficacy, acceptance, sense of coherence, and positive family function [ 49 , 50 ].…”

Section: Opportunities To Foster Resilience and Improve Care For Autimentioning

confidence: 99%

Coping, fostering resilience, and driving care innovation for autistic people and their families during the COVID-19 pandemic and beyond

et al. 2020

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The new coronavirus disease (COVID-19) pandemic is changing how society operates. Environmental changes, disrupted routines, and reduced access to services and social networks will have a unique impact on autistic individuals and their families and will contribute to significant deterioration in some. Access to support is crucial to address vulnerability factors, guide adjustments in home environments, and apply mitigation strategies to improve coping. The current crisis highlights that our regular care systems are not sufficient to meet the needs of the autism communities. In many parts of the world, people have shifted to online school and increased use of remote delivery of healthcare and autism supports. Access to these services needs to be increased to mitigate the negative impact of COVID-19 and future epidemics/pandemics. The rapid expansion in the use of telehealth platforms can have a positive impact on both care and research. It can help to address key priorities for the autism communities including long waitlists for assessment and care, access to services in remote locations, and restricted hours of service. However, system-level changes are urgently needed to ensure equitable access and flexible care models, especially for families and individuals who are socioeconomically disadvantaged. COVID-19 mandates the use of technology to support a broader range of care options and better meet the diverse needs of autistic people and their families. It behooves us to use this crisis as an opportunity to foster resilience not only for a given individual or their family, but also the system: to drive enduring and autism-friendly changes in healthcare, social systems, and the broader socio-ecological contexts.

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“…This proliferation of interest in resilience in recent decades is evidenced by the results from a PubMed search suggesting a fourfold increase in research using the keyword ‘resilience’ between 2008 and 2018, compared to only a 1.7-fold increase in research focused on ‘trauma and stress’ during that same time period (see also Kalisch et al, 2017 ). This growing body of research holds the promise of filling the prevention gap and suggests an emerging paradigm shift away from disease-focused to health-focused research (Kalisch et al, 2017 ; Murrough & Russo, 2019 ; Ungar & Theron, 2019 ), offering new insights into the mechanisms of stress resilience likely to yield novel therapeutics and prevention strategies (Dudek et al, 2020 ; Feder, Fred-Torres, Southwick, & Charney, 2019 ; Iacoviello & Charney, 2014 ; Mary et al, 2020 ; Moreno-Lopez et al, 2019 ).…”

Section: Introductionmentioning

confidence: 99%

Psychological resilience: an update on definitions, a critical appraisal, and research recommendations

Denckla

Cicchetti

Kubzansky³

et al. 2020

European Journal of Psychotraumatology

132

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The Biology of Human Resilience: Opportunities for Enhancing Resilience Across the Life Span

Cited by 179 publications

References 152 publications

Behavioral Traits Associated With Resilience to the Effects of Repeated Social Defeat on Cocaine-Induced Conditioned Place Preference in Mice

Behavioral Traits Associated With Resilience to the Effects of Repeated Social Defeat on Cocaine-Induced Conditioned Place Preference in Mice

Coping, fostering resilience, and driving care innovation for autistic people and their families during the COVID-19 pandemic and beyond

Psychological resilience: an update on definitions, a critical appraisal, and research recommendations

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